Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex

European Journal of Pharmaceutical Sciences

Volumn 33, Issue 3, 2008, Pages 217-229

  Geldof, Marian ^a   Freijer, Jan I ^b   Peletier, Lambertus A ^c   van Beijsterveldt, Ludy ^d   Danhof, Meindert ^a,b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LAP and P Consultants BV   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

^d JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Intracerebral microdialysis; Nonlinear mixed effects modeling; Pharmacokinetic pharmacodynamic modeling; Selective serotonin reuptake inhibitor; Serotonin reuptake transporter

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; AUTORECEPTOR; FLUVOXAMINE MALEATE; SEROTONIN; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG MECHANISM; EXPERIMENTAL MODEL; EXTRACELLULAR FLUID; FRONTAL CORTEX; MALE; MICRODIALYSIS; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN BRAIN LEVEL; SEROTONIN UPTAKE;

ANIMALS; FLUVOXAMINE; FRONTAL LOBE; HYDROXYINDOLEACETIC ACID; MALE; MODELS, BIOLOGICAL; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN UPTAKE INHIBITORS;

EID: 39649107978     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2007.12.001     Document Type: Article

References (49)

1. Ables A.Z., and Baughman III O.L. Antidepressants: update on new agents and indications. Am. Fam. Phys. 67 (2003) 547-554
2. Adell A., Casanovas J.M., and Artigas F. Comparative study in the rat of the actions of different types of stress on the release of 5-HT in raphe nuclei and forebrain areas. Neuropharmacology 36 (1997) 735-741
3. Artigas F. 5-HT and antidepressants: new views from microdialysis studies. Trends Pharmacol. Sci. 14 (1993) 262
4. Bel N., and Artigas F. Fluvoxamine preferentially increases extracellular 5-hydroxytryptamine in the raphe nuclei: an in vivo microdialysis study. Eur. J. Pharmacol. 229 (1992) 101-103
5. Bernillon P., and Bois F.Y. Statistical issues in toxicokinetic modeling: a Bayesian perspective. Environ. Health Perspect. 108 Suppl. 5 (2000) 883-893
6. Blier P., and de Montigny C. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse 1 (1987) 470-480
7. Bosker F.J., Klompmakers A.A., and Westenberg H.G. Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat. Neuropharmacology 34 (1995) 501-508
8. Briley M., and Moret C. Neurobiological mechanisms involved in antidepressant therapies. Clin. Neuropharmacol. 16 (1993) 387-400
9. Briley M., Chopin P., Marien M., and Moret C. Functional neuropharmacology of compounds acting at 5-HT1B/D receptors. In: Baumgarten H.G., and Göthert M. (Eds). Serotonergic Neurons and 5-HT Receptors in the CNS (1997), Springer-Verlag, Berlin 269-291
10. Bundgaard C., Larsen F., Jorgensen M., and Gabrielsson J. Mechanistic model of acute autoinhibitory feedback action after administration of SSRIs in rats: application to escitalopram-induced effects on brain serotonin levels. Eur. J. Pharm. Sci. 29 (2006) 394-404
11. Bymaster F.P., Zhang W., Carter P.A., Shaw J., Chernet E., Phebus L., Wong D.T., and Perry K.W. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berlin) 160 (2002) 353-361
12. Cespuglio R. In vivo measurement by differential pulse voltametry of 5-hydroxyindole compounds. J. Histochem. Cytochem. 30 (1982) 821-823
13. Cespuglio R., Faradj H., and Jouvet M. Voltammetric detection of extracellular 5-hydroxyindole compounds at the level of cell bodies and the terminals of the raphe system: variations during the wake-sleep cycle in the rat in chronic experiments. C. R. Seances Acad. Sci. III 296 (1983) 611-616
14. Commissiong J.W. Monoamine metabolites: their relationship and lack of relationship to monoaminergic neuronal activity. Biochem. Pharmacol. 34 (1985) 1127-1131
15. Coppen A. The biochemistry of affective disorders. Br. J. Psychiatry 113 (1967) 1237-1264
16. Denys D., Klompmakers A.A., and Westenberg H.G. Synergistic dopamine increase in the rat prefrontal cortex with the combination of quetiapine and fluvoxamine. Psychopharmacology (Berlin) 176 (2004) 195-203
17. Fujino K., Yoshitake T., Inoue O., Ibii N., Kehr J., Ishida J., Nohta H., and Yamaguchi M. Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors. Neurosci. Lett. 320 (2002) 91-95
18. Fuller R.W. Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. Life Sci. 55 (1994) 163-167
19. Gartside S.E., Umbers V., Hajos M., and Sharp T. Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. Br. J. Pharmacol. 115 (1995) 1064-1070
20. Geldof M., Freijer J., van Beijsterveldt L., Vermote P.C., Megens A.A., and Danhof M. Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior. Eur. J. Pharm. Sci. 32 (2007) 200-208
21. Geldof M., Freijer J., van Beijsterveldt L., Timmerman P., Ahnaou A., Drinkenburg W.H., and Danhof M. Population pharmacokinetic model of fluvoxamine in rats: utility for application in animal behavioral studies. Eur. J. Pharm. Sci. 30 (2007) 45-55
22. Göthert M., and Schlicker E. Regulation of 5-HT release in the CNS by presynaptic 5-HT autoreceptors and by 5-HT heteroreceptors. In: Baumgarten H.G., and Göthert M. (Eds). Serotonergic Neurons and 5-HT Receptors in the CNS (1997), Springer-Verlag, Berlin 307-350
23. Grahame-Smith D.G. Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and l-tryptophan. J. Neurochem. 18 (1971) 1053-1066
24. Hajos M., Hajos-Korcsok E., and Sharp T. Role of the medial prefrontal cortex in 5-HT1A receptor-induced inhibition of 5-HT neuronal activity in the rat. Br. J. Pharmacol. 126 (1999) 1741-1750
25. Hery F., Chouvet G., Kan J.P., Pujol J.F., and Glowinski J. Daily variations of various parameters of serotonin metabolism in the rat brain. II. Circadian variations in serum and cerebral tryptophan levels: lack of correlation with 5-HT turnover. Brain Res. 123 (1977) 137-145
26. Hjorth S. Serotonin 5-HT1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo: a microdialysis study. J. Neurochem. 60 (1993) 776-779
27. Hjorth S., and Auerbach S.B. Further evidence for the importance of 5-HT1A autoreceptors in the action of selective serotonin reuptake inhibitors. Eur. J. Pharmacol. 260 (1994) 251-255
28. Hutmacher M.M., Mukherjee D., Kowalski K.G., and Jordan D.C. Collapsing mechanistic models: an application to dose selection for proof of concept of a selective irreversible antagonist. J. Pharmacokinet. Pharmacodyn. 32 (2005) 501-520
29. Invernizzi R., Belli S., and Samanin R. Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex. Brain Res. 584 (1992) 322-324
30. Isaac M. Where are we going with SSRIs?. Eur. Neuropsychopharmacol. 9 Suppl. 3 (1999) S101-S106
31. Kalen P., Rosegren E., Lindvall O., and Bjorklund A. Hippocampal noradrenaline and serotonin release over 24 hours as measured by the dialysis technique in freely moving rats: correlation to behavioural activity state, effect of handling and tail-pinch. Eur. J. Neurosci. 1 (1989) 181-188
32. Kalen P., Strecker R.E., Rosengren E., and Bjorklund A. Endogenous release of neuronal serotonin and 5-hydroxyindoleacetic acid in the caudate-putamen of the rat as revealed by intracerebral dialysis coupled to high-performance liquid chromatography with fluorimetric detection. J. Neurochem. 51 5 (1988) 1422-1435
33. Kirby L.G., and Lucki I. Interaction between the forced swimming test and fluoxetine treatment on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the rat. J. Pharmacol. Exp. Ther. 282 (1997) 967-976
34. Malagie I., Trillat A.C., Jacquot C., and Gardier A.M. Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study. Eur. J. Pharmacol. 286 (1995) 213-217
35. McGinty D.J., and Harper R.M. Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res. 101 (1976) 569-575
36. Mochizuki D., Tsujita R., Yamada S., Kawasaki K., Otsuka Y., Hashimoto S., Hattori T., Kitamura Y., and Miki N. Neurochemical and behavioural characterization of milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats. Psychopharmacology (Berlin) 162 (2002) 323-332
37. Moghaddam B., and Bunney B.S. Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine. J. Neurochem. 53 (1989) 652-654
38. Moret C., and Briley M. Ex vivo inhibitory effect of the 5-HT uptake blocker citalopram on 5-HT synthesis. J. Neural Transm. 104 (1997) 147-160
39. Neckers L.M., and Meek J.L. Measurement of 5HT turnover rate in discrete nuclei of rat brain. Life Sci. 19 (1976) 1579-1584
40. Neff N.H., and Tozer T.N. In vivo measurement of brain serotonin turnover. Adv. Pharmacol. 6 (1968) 97-109
41. Owens M.J., and Nemeroff C.B. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin. Chem. 40 (1994) 288-295
42. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1982), Academic Press
43. Puizillout J.J., Gaudin-Chazal G., Daszuta A., Seyfritz N., and Ternaux J.P. Release of endogenous serotonin from "encephale isole" cats. II. Correlations with raphe neuronal activity and sleep and wakefulness. J. Physiol. (Paris) 75 (1979) 531-537
44. Quay W.B. Differences in circadian rhythms in 5-hydroxytryptamine according to brain region. Am. J. Physiol. 215 (1968) 1448-1453
45. Semba J., Toru M., and Mataga N. Twenty-four hour rhythms of norepinephrine and serotonin in nucleus suprachiasmaticus, raphe nuclei, and locus coeruleus in the rat. Sleep 7 (1984) 211-218
46. Shachar D., Klein E., Tabak A., and Finberg J.P. Effect of single and repeated administration of fluvoxamine on noradrenaline release in rat brain. Eur. J. Pharmacol. 332 (1997) 237-243
47. Sotelo C., Cholley B., El Mestikawy S., Gozlan H., and Hamon M. Direct immunohistochemical evidence of the existence of 5-HT1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei. Eur. J. Neurosci. 2 (1990) 1144-1154
48. Sprouse J.S., and Aghajanian G.K. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse 1 (1987) 3-9
49. Wolf W.A., Youdim M.B., and Kuhn D.M. Does brain 5-HIAA indicate serotonin release or monoamine oxidase activity?. Eur. J. Pharmacol. 109 (1985) 381-387