Effect of VEGF receptor antagonist (VGA1155) on brain edema in the rat cold injury model

Kobe Journal of Medical Sciences

Volumn 53, Issue 5, 2007, Pages 199-207

  Koyama, Junji ^a   Miyake, Shigeru ^a   Sasayama, Takashi ^a   Kondoh, Takeshi ^a   Kohmura, Eiji ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cold injury; Vascular endothelial growth factor; Vasogenic edema; VGA1155

Indexed keywords

5 [N METHYL N (4 OCTADECYLOXYPHENYL)ACETYL]AMINO 2 METHYLTHIOBENZOIC ACID; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR; VGA 1155;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN EDEMA; BRAIN WATER; COLD INJURY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HISTOPATHOLOGY; MALE; NONHUMAN; RAT; THERAPY DELAY;

ANIMALS; BENZOIC ACIDS; BLOOD-BRAIN BARRIER; BRAIN EDEMA; CAPILLARY PERMEABILITY; COLD; MALE; RATS; RATS, INBRED F344; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 39649090549     PISSN: 00232513     EISSN: 18830498     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Bates, D.O., Curry, F.E. 1996. Vascular endothelial growth factor increases hydraulic conductivity of isolated perfused microvessels. Am J Physiol. 271:H2520-2528.
2. Bemana, I., Nagao, S. 1999. Treatment of brain edema with a nonpeptide arginine vasopressin V1 receptor antagonist OPC-21268 in rats. Neurosurgery. 44:148-155.
3. Ferrara, N., Chen, H., Davis-Smyth, T., Gerber, H.P., Nguyen, T.N., Peers, D., Chisholm, V., Hillan, K.J., Schwall, R.H. 1998. Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat Med. 4:336-340.
4. Ferrara, N. 2004. Vascular endothelial growth factor: Basic science and clinical progress. Endocrine Reviews. 25:581-611.
5. Hai, J., Li, S.T., Lin, Q., Pan, Q.G., Gao, F., Ding, M.X. 2003. Vascular endothelia growth factor expression and angiogenesis induced by chronic cerebral hypoperfusion in rat brain. Neurosurgery. 53:963-972.
6. Ikeda, Y., Long, D.M. 1990. The molecular basis of brain injury and brain edema: The role of oxygen free radicals. Neurosurgery. 27:1-11.
7. Kimura, R., Nakase, H., Tamaki, R., Sakaki, T. 2005. Vascular endothelial growth factor antagonist reduces brain edema formation and venous infarction. Stroke 36:1259-1263.
8. Klatzo, I., Piraux, A., Laskowski, E.J. 1958. The relationship between edema, blood-brain barrier, and tissue elements in a local brain injury. J Neuropathol Exp Neurol. 17:548-564.
9. Lenzlinger, P.M., Saatman, K.E., Hoover, R.C., Cheney, J.A., Bareyre, F.M., Raghupathi, R., Arnold, L.D., McIntosh, T.K. 2004. Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling by BSF476921 attenuates regional cerebral edema following traumatic brain injury in rats. Restor Neurol Neurosci. 22:73-79.
10. Machein, M.R., Kullmer, J., Fiebich, B.L., Plate, K.H., Warnke, P.C. 1999. Vascular endothelial growth factor expression, vascular volume, and, capillary permeability in human brain tumors. Neurosurgery. 44:732-740.
11. Machein, M.R., Plate, K.H. 2000. VEGF in brain tumors. J Neurooncol. 50:109-120. Review.
12. Nag, S., Eskandarian, M.R., Davis, J., Eubanks, J.H. 2002. Differential expression of vascular endothelial growth factor-A (VEGF-A) and VEGF-B after brain injury. Neuropathol Exp Neurol. 61:778-788.
13. Nag, S., Takahashi, J.L., Kilty, D.W. 1997. Role of vascular endothelial growth factor in blood-brain barrier breakdown and angiogenesis in brain trauma. J Neuropathol Exp Neurol. 56:912-921.
14. Papavassiliou, E., Gogate, N., Proescholdt, M., Heiss, J.D., Walbridge, S., Edwards, N.A., Oldfield, E.H., Merrill, M.J. 1997. Vascular endothelial growth factor (vascular permeability factor) expression in injured rat brain. J Neurosci Res. 49:451-460.
15. Pichiule, P., Chavez, J.C., Xu, K., LaManna, J.C. 1999. Vascular endothelial growth factor upregulation in transient global ischemia induced by cardiac arrest and resuscitation in rat brain. Brain Res Mol Brain Res. 74:83-90.
16. Schoch, H.J., Fischer, S., Marti, H.H. 2002. Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain. Brain. 125:2549-2557.
17. Ueda, Y., Yamagishi, T., Ikeya, H., Hirayama, N., Itokawa, T., Aozuka, Y., Samata, K., Nakaike, S., Tanaka, M., Ono, M., Saiki, I. 2004. VGA1155, a novel binding antagonist of VEGF, inhibits angiogenesis in vitro and in vivo. Anticancer Res. 24:3009-3017.
18. Ueda, Y., Yamagishi, T., Samata, K., Ikeya, H., Hirayama, N., Takashima, H., Nakaike, S., Tanaka, M., Saiki, I. 2003. A novel low molecular weight antagonist of vascular endothelial growth factor receptor binding: VGA1155. Mol Cancer Ther. 2:1105-1111.
19. van Bruggen, N., Thibodeaux, H., Palmer, J.T., Lee, W.P., Fu, L., Cairns, B., Tumas, D., Gerlai, R., Williams, S.P., van Lookeren, Campagne, M., Ferrara, N. 1999. VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. J Clin Invest. 104:1613-1620.
20. Zhang, Z.G., Zhang, L., Jiang, Q., Zhang, R., Davies, K., Powers, C. 2000. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest. 106:829-838.