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Volumn 4, Issue 1, 2008, Pages 61-71

Remyelination after chronic spinal cord injury is associated with proliferation of endogenous adult progenitor cells after systemic administration of guanosine

Author keywords

Cell proliferation; Functional recovery; Guanine; Guanosine; Immunohistochemistry; Myelination; Oligodendrocyte; Precursors; Spinal cord

Indexed keywords


EID: 39549112277     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-007-9093-8     Document Type: Article
Times cited : (49)

References (70)
  • 1
    • 0001918961 scopus 로고
    • Ultrastructural study of remyelination in an experimental lesion in adult cat spinal cord
    • Bunge MB, Bunge RP, Ris H (1961) Ultrastructural study of remyelination in an experimental lesion in adult cat spinal cord. J Biophys Biochem Cytol 10:67-94
    • (1961) J Biophys Biochem Cytol , vol.10 , pp. 67-94
    • Bunge, M.B.1    Bunge, R.P.2    Ris, H.3
  • 2
    • 0027343542 scopus 로고
    • Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination
    • Bunge RP, Puckett WR, Becerra JL, Marcillo A, Quencer RM (1993) Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination. Adv Neurol 59:75-89
    • (1993) Adv Neurol , vol.59 , pp. 75-89
    • Bunge, R.P.1    Puckett, W.R.2    Becerra, J.L.3    Marcillo, A.4    Quencer, R.M.5
  • 3
    • 33646589292 scopus 로고    scopus 로고
    • Demyelination and remyelination after spinal cord injury
    • McDonald JW, Belegu V (2006) Demyelination and remyelination after spinal cord injury. J Neurotrauma 23:345-359
    • (2006) J Neurotrauma , vol.23 , pp. 345-359
    • McDonald, J.W.1    Belegu, V.2
  • 5
    • 0028273403 scopus 로고
    • A monoclonal antibody (IN-1) which neutralizes neurite growth inhibitory proteins in the rat CNS recognizes antigens localized in CNS myelin
    • Dusart I, Schwab ME (1994) A monoclonal antibody (IN-1) which neutralizes neurite growth inhibitory proteins in the rat CNS recognizes antigens localized in CNS myelin. J Neurocytol 23:209-217
    • (1994) J Neurocytol , vol.23 , pp. 209-217
    • Dusart, I.1    Schwab, M.E.2
  • 7
    • 33646577436 scopus 로고    scopus 로고
    • Degenerative and spontaneous regenerative processes after spinal cord injury
    • Hagg T, Oudega M (2006) Degenerative and spontaneous regenerative processes after spinal cord injury. J Neurotrauma 23:264-280
    • (2006) J Neurotrauma , vol.23 , pp. 264-280
    • Hagg, T.1    Oudega, M.2
  • 9
    • 0027157685 scopus 로고
    • Failure of remyelination in areas of demyelination produced in the spinal cord of old rats
    • Gilson J, Blakemore WF (1993) Failure of remyelination in areas of demyelination produced in the spinal cord of old rats. Neuropathol Appl Neurobiol 19:173-181
    • (1993) Neuropathol Appl Neurobiol , vol.19 , pp. 173-181
    • Gilson, J.1    Blakemore, W.F.2
  • 10
    • 0023673968 scopus 로고
    • Remyelination in the central nervous system and the peripheral nervous system
    • Ludwin SK (1988) Remyelination in the central nervous system and the peripheral nervous system. Adv Neurol 47:215-254
    • (1988) Adv Neurol , vol.47 , pp. 215-254
    • Ludwin, S.K.1
  • 11
    • 0018774226 scopus 로고
    • Central remyelination restores secure conduction
    • Smith EJ, Blakemore WF, McDonald WI (1979) Central remyelination restores secure conduction. Nature 280:395-396
    • (1979) Nature , vol.280 , pp. 395-396
    • Smith, E.J.1    Blakemore, W.F.2    McDonald, W.I.3
  • 12
    • 0030006863 scopus 로고    scopus 로고
    • Do oligodendrocytes divide?
    • Norton WT (1996) Do oligodendrocytes divide? Neurochem Res 21:495-503
    • (1996) Neurochem Res , vol.21 , pp. 495-503
    • Norton, W.T.1
  • 13
    • 0030861649 scopus 로고    scopus 로고
    • Endogenous progenitors remyelinate demyelinated axons in the adult CNS
    • Gensert JM, Goldman JE (1997) Endogenous progenitors remyelinate demyelinated axons in the adult CNS. Neuron 19:197-203
    • (1997) Neuron , vol.19 , pp. 197-203
    • Gensert, J.M.1    Goldman, J.E.2
  • 15
    • 0035873062 scopus 로고    scopus 로고
    • Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord
    • McTigue DM, Wei P, Stokes BT (2001) Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord. J Neurosci 21:3392-3400
    • (2001) J Neurosci , vol.21 , pp. 3392-3400
    • McTigue, D.M.1    Wei, P.2    Stokes, B.T.3
  • 17
    • 0033200090 scopus 로고    scopus 로고
    • Regenerative potential of adult O1+ oligodendrocytes
    • Rosano C, Felipe-Cuervo E, Wood PM (1999) Regenerative potential of adult O1+ oligodendrocytes. Glia 27:189-202
    • (1999) Glia , vol.27 , pp. 189-202
    • Rosano, C.1    Felipe-Cuervo, E.2    Wood, P.M.3
  • 18
    • 0036848529 scopus 로고    scopus 로고
    • Ciliary neuro-trophic factor (CNTF) enhances myelin formation: A novel role for CNTF and CNTF-related molecules
    • Stankoff B, Aigrot MS, Noel F, Wattilliaux A, Zalc B, Lubetzki C (2002) Ciliary neuro-trophic factor (CNTF) enhances myelin formation: A novel role for CNTF and CNTF-related molecules. J Neurosci 22:9221-9227
    • (2002) J Neurosci , vol.22 , pp. 9221-9227
    • Stankoff, B.1    Aigrot, M.S.2    Noel, F.3    Wattilliaux, A.4    Zalc, B.5    Lubetzki, C.6
  • 19
    • 0032528159 scopus 로고    scopus 로고
    • Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord
    • McTigue DM, Horner PJ, Stokes BT, Gage FH (1998) Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J Neurosci 18:5354-5365
    • (1998) J Neurosci , vol.18 , pp. 5354-5365
    • McTigue, D.M.1    Horner, P.J.2    Stokes, B.T.3    Gage, F.H.4
  • 20
    • 0035066639 scopus 로고    scopus 로고
    • Biology of oligodendrocyte and myelin in the mammalian central nervous system
    • Baumann N, Pham-Dinh D (2001) Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev 81:871-927
    • (2001) Physiol Rev , vol.81 , pp. 871-927
    • Baumann, N.1    Pham-Dinh, D.2
  • 21
    • 0042858516 scopus 로고    scopus 로고
    • Molecular approaches to spinal cord repair
    • David S, Lacroix S (2003) Molecular approaches to spinal cord repair. Annu Rev Neurosci 26:411-440
    • (2003) Annu Rev Neurosci , vol.26 , pp. 411-440
    • David, S.1    Lacroix, S.2
  • 22
    • 0034718896 scopus 로고    scopus 로고
    • Regenerating the damaged central nervous system
    • Horner PJ, Gage FH (2000) Regenerating the damaged central nervous system. Nature 407:963-970
    • (2000) Nature , vol.407 , pp. 963-970
    • Horner, P.J.1    Gage, F.H.2
  • 23
    • 0034332486 scopus 로고    scopus 로고
    • NT-3 weakly stimulates proliferation of adult rat O1(-)O4(+) oligodendrocyte-lineage cells and increases oligodendrocyte myelination in vitro
    • Yan H, Wood PM (2000) NT-3 weakly stimulates proliferation of adult rat O1(-)O4(+) oligodendrocyte-lineage cells and increases oligodendrocyte myelination in vitro. J Neurosci Res 62:329-335
    • (2000) J Neurosci Res , vol.62 , pp. 329-335
    • Yan, H.1    Wood, P.M.2
  • 24
    • 0035655438 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 inhibits myelin production by oligodendrocytes in vivo
    • Goddard DR, Berry M, Kirvell SL, Butt AM (2001) Fibroblast growth factor-2 inhibits myelin production by oligodendrocytes in vivo. Mol Cell Neurosci 18:557-569
    • (2001) Mol Cell Neurosci , vol.18 , pp. 557-569
    • Goddard, D.R.1    Berry, M.2    Kirvell, S.L.3    Butt, A.M.4
  • 26
    • 0034099929 scopus 로고    scopus 로고
    • Extracellular guanosine 5′ triphosphate enhances nerve growth factor-induced neurite outgrowth via increases in intracellular calcium
    • Gysbers JW, Guarnieri S, Mariggio MA, Pietrangelo T, Fano G, Rathbone MP (2000) Extracellular guanosine 5′ triphosphate enhances nerve growth factor-induced neurite outgrowth via increases in intracellular calcium. Neuroscience 96:817-824
    • (2000) Neuroscience , vol.96 , pp. 817-824
    • Gysbers, J.W.1    Guarnieri, S.2    Mariggio, M.A.3    Pietrangelo, T.4    Fano, G.5    Rathbone, M.P.6
  • 28
    • 0034142055 scopus 로고    scopus 로고
    • Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia
    • Ciccarelli R, Di Iorio P, D'Alimonte I, Giulani P, Florio T, Caciagli F, Middlemiss PJ, Rathbone MP (2000) Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia. Glia 29:202-211
    • (2000) Glia , vol.29 , pp. 202-211
    • Ciccarelli, R.1    Di Iorio, P.2    D'Alimonte, I.3    Giulani, P.4    Florio, T.5    Caciagli, F.6    Middlemiss, P.J.7    Rathbone, M.P.8
  • 29
    • 0026468615 scopus 로고
    • Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells
    • Gysbers JW, Rathbone MP (1992) Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells. Neuroreport 3:997-1000
    • (1992) Neuroreport , vol.3 , pp. 997-1000
    • Gysbers, J.W.1    Rathbone, M.P.2
  • 30
    • 0029924599 scopus 로고    scopus 로고
    • GTP and guanosine synergistically enhance NGF-induced neurite outgrowth from PC12 cells
    • Gysbers JW, Rathbone MP (1996) GTP and guanosine synergistically enhance NGF-induced neurite outgrowth from PC12 cells. Int J Dev Neurosci 14:19-34
    • (1996) Int J Dev Neurosci , vol.14 , pp. 19-34
    • Gysbers, J.W.1    Rathbone, M.P.2
  • 32
    • 0025760707 scopus 로고
    • Morphometric analysis of a model of spinal cord injury in guinea pigs, with behavioral evidence of delayed secondary pathology
    • Blight AR (1991) Morphometric analysis of a model of spinal cord injury in guinea pigs, with behavioral evidence of delayed secondary pathology. J Neurol Sci 103:156-171
    • (1991) J Neurol Sci , vol.103 , pp. 156-171
    • Blight, A.R.1
  • 33
    • 0030570810 scopus 로고    scopus 로고
    • Histological and functional evaluation of experimental spinal cord injury: Evidence of a stepwise response to graded compression
    • Gruner JA, Yee AK, Blight AR (1996) Histological and functional evaluation of experimental spinal cord injury: Evidence of a stepwise response to graded compression. Brain Res 729:90-101
    • (1996) Brain Res , vol.729 , pp. 90-101
    • Gruner, J.A.1    Yee, A.K.2    Blight, A.R.3
  • 36
    • 0028919411 scopus 로고
    • A sensitive and reliable locomotor rating scale for open field testing in rats
    • Basso DM, Beattie MS, Bresnahan JC (1995) A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21
    • (1995) J Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 37
    • 0030157694 scopus 로고    scopus 로고
    • Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection
    • Basso DM, Beattie MS, Bresnahan JC (1996) Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 139:244-256
    • (1996) Exp Neurol , vol.139 , pp. 244-256
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 39
    • 0024310302 scopus 로고
    • In situ demonstration of mature oligodendrocytes and their processes: An immunocytochemical study with a new monoclonal antibody, rip
    • Friedman B, Hockfield S, Black JA, Woodruff KA, Waxman SG (1989) In situ demonstration of mature oligodendrocytes and their processes: An immunocytochemical study with a new monoclonal antibody, rip. Glia 2:380-390
    • (1989) Glia , vol.2 , pp. 380-390
    • Friedman, B.1    Hockfield, S.2    Black, J.A.3    Woodruff, K.A.4    Waxman, S.G.5
  • 41
    • 0030785547 scopus 로고    scopus 로고
    • Identification of post-mitotic oligodendrocytes incapable of remyelination within the demyelinated adult spinal cord
    • Keirstead HS, Blakemore WF (1997) Identification of post-mitotic oligodendrocytes incapable of remyelination within the demyelinated adult spinal cord. J Neuropathol Exp Neurol 56:1191-1201
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 1191-1201
    • Keirstead, H.S.1    Blakemore, W.F.2
  • 42
    • 0032533690 scopus 로고    scopus 로고
    • In vivo proliferation of oligodendrocyte progenitors expressing PDGFalphaR during early remyelination
    • Redwine JM, Armstrong RC (1998) In vivo proliferation of oligodendrocyte progenitors expressing PDGFalphaR during early remyelination. J Neurobiol 37:413-428
    • (1998) J Neurobiol , vol.37 , pp. 413-428
    • Redwine, J.M.1    Armstrong, R.C.2
  • 43
    • 29644445235 scopus 로고    scopus 로고
    • NG2-expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult central nervous system
    • Polito A, Reynolds R (2005) NG2-expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult central nervous system. J Anat 207:707-716
    • (2005) J Anat , vol.207 , pp. 707-716
    • Polito, A.1    Reynolds, R.2
  • 44
    • 0142250835 scopus 로고    scopus 로고
    • NG2-expressing glial progenitor cells: An abundant and widespread population of cycling cells in the adult rat CNS
    • Dawson MR, Polito A, Levine JM, Reynolds R (2003) NG2-expressing glial progenitor cells: An abundant and widespread population of cycling cells in the adult rat CNS. Mol Cell Neurosci 24:476-488
    • (2003) Mol Cell Neurosci , vol.24 , pp. 476-488
    • Dawson, M.R.1    Polito, A.2    Levine, J.M.3    Reynolds, R.4
  • 45
    • 0031932057 scopus 로고    scopus 로고
    • Identification of the adult resting progenitor cell by autoradiographic tracking of oligodendrocyte precursors in experimental CNS demyelination
    • Carroll WM, Jennings AR, Ironside LJ (1998) Identification of the adult resting progenitor cell by autoradiographic tracking of oligodendrocyte precursors in experimental CNS demyelination. Brain 121:293-302
    • (1998) Brain , vol.121 , pp. 293-302
    • Carroll, W.M.1    Jennings, A.R.2    Ironside, L.J.3
  • 46
    • 0032005795 scopus 로고    scopus 로고
    • Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord
    • Keirstead HS, Levine JM, Blakemore WF (1998) Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord. Glia 22:161-170
    • (1998) Glia , vol.22 , pp. 161-170
    • Keirstead, H.S.1    Levine, J.M.2    Blakemore, W.F.3
  • 47
    • 0032763125 scopus 로고    scopus 로고
    • Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination
    • Levine JM, Reynolds R (1999) Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination. Exp Neurol 160:333-347
    • (1999) Exp Neurol , vol.160 , pp. 333-347
    • Levine, J.M.1    Reynolds, R.2
  • 48
    • 34047245282 scopus 로고    scopus 로고
    • Glial cell loss, proliferation and replacement in the contused murine spinal cord
    • Lytle JM, Wrathall JR (2007) Glial cell loss, proliferation and replacement in the contused murine spinal cord. Eur J Neurosci 25:1711-1724
    • (2007) Eur J Neurosci , vol.25 , pp. 1711-1724
    • Lytle, J.M.1    Wrathall, J.R.2
  • 49
    • 34548206670 scopus 로고    scopus 로고
    • Astrocytes - Friends or foes in multiple sclerosis?
    • Williams A, Piaton G, Lubetzki C (2007) Astrocytes - friends or foes in multiple sclerosis? Glia 55:1300-1312
    • (2007) Glia , vol.55 , pp. 1300-1312
    • Williams, A.1    Piaton, G.2    Lubetzki, C.3
  • 53
    • 0036735672 scopus 로고    scopus 로고
    • Neuronal replacement from endogenous precursors in the adult brain after stroke
    • Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O (2002) Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 8:963-970
    • (2002) Nat Med , vol.8 , pp. 963-970
    • Arvidsson, A.1    Collin, T.2    Kirik, D.3    Kokaia, Z.4    Lindvall, O.5
  • 54
    • 33750027699 scopus 로고    scopus 로고
    • Bcl-2 enhances neurogenesis and inhibits apoptosis of newborn neurons in adult rat brain following a transient middle cerebral artery occlusion
    • Zhang R, Xue YY, Lu SD, Wang Y, Zhang LM, Huang YL, Signore AP, Chen J, Sun FY (2006) Bcl-2 enhances neurogenesis and inhibits apoptosis of newborn neurons in adult rat brain following a transient middle cerebral artery occlusion. Neurobiol Dis 24:345-356
    • (2006) Neurobiol Dis , vol.24 , pp. 345-356
    • Zhang, R.1    Xue, Y.Y.2    Lu, S.D.3    Wang, Y.4    Zhang, L.M.5    Huang, Y.L.6    Signore, A.P.7    Chen, J.8    Sun, F.Y.9
  • 55
    • 0034254162 scopus 로고    scopus 로고
    • Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination
    • Mason JL, Jones JJ, Taniike M, Morell P, Suzuki K, Matsushima GK (2000) Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination. J Neurosci Res 61:251-262
    • (2000) J Neurosci Res , vol.61 , pp. 251-262
    • Mason, J.L.1    Jones, J.J.2    Taniike, M.3    Morell, P.4    Suzuki, K.5    Matsushima, G.K.6
  • 56
    • 0026544584 scopus 로고
    • Role of adult oligodendrocytes in remyelination after neural injury
    • Vick RS, Neuberger TJ, Devries GH (1992) Role of adult oligodendrocytes in remyelination after neural injury. J Neurotrauma 9:S93-S103
    • (1992) J Neurotrauma , vol.9
    • Vick, R.S.1    Neuberger, T.J.2    Devries, G.H.3
  • 57
    • 0029819746 scopus 로고    scopus 로고
    • Nerve growth factor and neurotrophin-3 differentially regulate the proliferation and survival of developing rat brain oligodendrocytes
    • Cohen RI, Marmur R, Norton WT, Mehler MF, Kessler JA (1996) Nerve growth factor and neurotrophin-3 differentially regulate the proliferation and survival of developing rat brain oligodendrocytes. J Neurosci 16:6433-6442
    • (1996) J Neurosci , vol.16 , pp. 6433-6442
    • Cohen, R.I.1    Marmur, R.2    Norton, W.T.3    Mehler, M.F.4    Kessler, J.A.5
  • 58
    • 0028843277 scopus 로고
    • Basic fibroblast growth factor down-regulates myelin basic protein gene expression and alters myelin compaction of mature oligodendrocytes in vitro
    • Fressinaud C, Vallat JM, Labourdette G (1995) Basic fibroblast growth factor down-regulates myelin basic protein gene expression and alters myelin compaction of mature oligodendrocytes in vitro. J Neurosci Res 40:285-293
    • (1995) J Neurosci Res , vol.40 , pp. 285-293
    • Fressinaud, C.1    Vallat, J.M.2    Labourdette, G.3
  • 59
    • 0027527155 scopus 로고
    • Regulation of oligodendrocyte development and central nervous system myelination by insulin-like growth factors
    • McMorris FA, Mozell RL, Carson MJ, Shinar Y, Meyer RD, Marchetti N (1993) Regulation of oligodendrocyte development and central nervous system myelination by insulin-like growth factors. Ann N Y Acad Sci 692:321-334
    • (1993) Ann N Y Acad Sci , vol.692 , pp. 321-334
    • McMorris, F.A.1    Mozell, R.L.2    Carson, M.J.3    Shinar, Y.4    Meyer, R.D.5    Marchetti, N.6
  • 60
    • 0030017545 scopus 로고    scopus 로고
    • Regulation of oligodendrocyte development and CNS myelination by growth factors: Prospects for therapy of demyelinating disease
    • McMorris FA, McKinnon RD (1996) Regulation of oligodendrocyte development and CNS myelination by growth factors: Prospects for therapy of demyelinating disease. Brain Pathol 6:313-329
    • (1996) Brain Pathol , vol.6 , pp. 313-329
    • McMorris, F.A.1    McKinnon, R.D.2
  • 61
    • 0030781924 scopus 로고    scopus 로고
    • FGF-2 converts mature oligodendrocytes to a novel phenotype
    • Bansal R, Pfeiffer SE (1997) FGF-2 converts mature oligodendrocytes to a novel phenotype. J Neurosci Res 50:215-228
    • (1997) J Neurosci Res , vol.50 , pp. 215-228
    • Bansal, R.1    Pfeiffer, S.E.2
  • 65
    • 0031962240 scopus 로고    scopus 로고
    • Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells
    • Wolswijk G (1998) Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells. J Neurosci 18:601-609
    • (1998) J Neurosci , vol.18 , pp. 601-609
    • Wolswijk, G.1
  • 66
    • 0034281366 scopus 로고    scopus 로고
    • NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions
    • Chang A, Nishiyama A, Peterson J, Prineas J, Trapp BD (2000) NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J Neurosci 20:6404-6412
    • (2000) J Neurosci , vol.20 , pp. 6404-6412
    • Chang, A.1    Nishiyama, A.2    Peterson, J.3    Prineas, J.4    Trapp, B.D.5
  • 67
    • 0037122960 scopus 로고    scopus 로고
    • Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
    • Chang A (2002) Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N Engl J Med 346:165-173
    • (2002) N Engl J Med , vol.346 , pp. 165-173
    • Chang, A.1
  • 68
    • 0031797815 scopus 로고    scopus 로고
    • Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis
    • Scolding N, Franklin R, Stevens S, Heldin CH, Compston A, Newcombe J (1998) Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis. Brain 121:2221-2228
    • (1998) Brain , vol.121 , pp. 2221-2228
    • Scolding, N.1    Franklin, R.2    Stevens, S.3    Heldin, C.H.4    Compston, A.5    Newcombe, J.6
  • 69
    • 33746055320 scopus 로고    scopus 로고
    • Co-expression of PDGF alpha receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions
    • Wilson HC, Scolding NJ, Raine CS (2006) Co-expression of PDGF alpha receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions. J Neuroimmunol 176:162-173
    • (2006) J Neuroimmunol , vol.176 , pp. 162-173
    • Wilson, H.C.1    Scolding, N.J.2    Raine, C.S.3


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