UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations

International Journal of Pharmaceutics

Volumn 352, Issue 1-2, 2008, Pages 123-128

  Tashtoush, Bassam M ^a   Jacobson, Elaine L ^b   Jacobson, Myron K ^b  

^a JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Jordan)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Photoisomerization; Photolysis; Photostability; Retinoic acid; UVA

Indexed keywords

ALCOHOL; ISOTRETINOIN; RETINOIC ACID; TRIFLUOROACETIC ACID;

ARTICLE; DRUG FORMULATION; DRUG HALF LIFE; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERIZATION; PHOTODEGRADATION; PHOTOLYSIS; PRIORITY JOURNAL; SOLAR RADIATION; ULTRAVIOLET A RADIATION;

CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DERMATOLOGIC AGENTS; DRUG COMPOUNDING; DRUG STABILITY; ETHANOL; HALF-LIFE; ISOTRETINOIN; KINETICS; LIGHT; OINTMENTS; PHOTOLYSIS; SUNLIGHT; TECHNOLOGY, PHARMACEUTICAL; TRETINOIN; ULTRAVIOLET RAYS;

EID: 39549089696     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.10.045     Document Type: Article

References (19)

1. Brisaert M.G., Everaerts I., and Plaizier-Vercammen J.A. Chemical stability of tretinoin in dermatological preparation. Pharm. Acta Helv. 70 (1995) 161-166
2. Brisaert M., Gabriels M., Matthijs V., and Plaizier-Vercammen J. Liposomes with tretinoin: a physical and chemical evaluation. J. Pharm. Biomed. Anal. 26 (2001) 909-917
3. Brisaert M., and Plaizier-Vercammen J. Investigation on the photostability of a tretinoin lotion and stabilization with additives. Int. J. Pharm. 199 (2000) 49-57
4. Brisaert M., and Plaizier-Vercammen J.A. Investigation on the photostability of tretinoin in creams. Int. J. Pharm. 334 (2007) 56-61
5. Cahnmann H.J. A fast photoisomerization method for the preparation of tritium-labeled 9-cis-retinoic acid of high specific activity. Anal. Biochem. 227 (1995) 49-53
6. Chivot M. Retinoid therapy for acne. A comparative review. Am. J. Clin. Dermatol. 6 (2005) 13-19
7. Curley Jr. R.W., and Fowble J.W. Photoisomerization of retinoic acid and its photoprotection in physiologic-like solutions. Photochem. Photobiol. 47 (1988) 831-835
8. Fisher G.J., and Voorhees J.J. Molecular mechanisms of retinoid actions in skin. FASEB J. 10 (1996) 1002-1013
9. Ioele G., Cione E., Risoli A., Genchi G., and Ragno G. Accelerated photostability study of tretinoin and isotretinoin in liposome formulations. Int. J. Pharm. 293 (2005) 251-260
10. Kang S., Bergfeld W., Gottlieb A.B., Hickman J., Humeniuk J., Kempers S., Lebwohl M., Lowe N., McMichael A., Milbauer J., Phillips T., Powers J., Rodriguez D., Savin R., Shavin J., Sherer D., Silvis N., Weinstein R., Weiss J., Hammerberg C., Fisher G.J., Nighland M., Grossman R., and Nyirady J. Long-term efficacy and safety of tretinoin emollient cream 0.05% in the treatment of photodamaged facial skin: a two-year, randomized, placebo-controlled trial. Am. J. Clin. Dermatol. 6 (2005) 245-253
11. Layton A.M., and Cunliffe W.J. Guidelines for optimal use of isotretinoin in acne. J. Am. Acad. Dermatol. 27 (1992) S2-S7
12. Lovat P.E., Irving H., Malcolm A.J., Pearson A.D., and Redfern C.P. 9-cis retinoic acid-a better retinoid for the modulation of differentiation, proliferation and gene expression in human neuroblastoma. J. Neurooncol. 31 (1997) 85-91
13. Lucero M.J., Vigo J., and Leon M.J. Stability of hydrophilic gels of tretinoin. Int. J. Pharm. 110 (1994) 241-248
14. Manconi M., Valenti D., Sinico C., Lai F., Loy G., and Fadda A.M. Niosomes as carriers for tretinoin II. Influence of vesicular incorporation on tretinoin photostability. Int. J. Pharm. 260 (2003) 261-272
15. Orfanos C.E., Zouboulis C.C., Almond-Roesler B., and Geilen C.C. Current use and future potential role of retinoids in dermatology. Drugs 53 (1997) 358-388
16. Tan X., Meltzer N., and Lindebaum S. Solid-state stability studies of 13-cis-retinoic acid and all-trans-retinoic acid using microcalorimetry and HPLC analysis. Pharm. Res. 9 (1992) 1203-1208
17. Tan X., Meltzer N., and Lindenbaum S. Determination of the kinetics of degradation of 13-cis-retinoic acid and all-trans-retinoic acid in solution. J. Pharm. Biomed. Anal. 11 (1993) 817-822
18. Tashtoush B.M., Jacobson E.L., and Jacobson M.K. A rapid HPLC method for simultaneous determination of tretinoin and isotretinoin in dermatological formulations. J. Pharm. Biomed. Anal. 43 (2007) 859-864
19. Yap K.L., Liu X., Thenmozhiyal J.C., and Ho P.C. Characterization of the 13-cis-retinoic acid/cyclodextrin inclusion complexes by phase solubility, photostability, physicochemical and computational analysis. Eur. J. Pharm. Sci. 25 (2005) 49-56