Sample stability and protein composition of saliva: Implications for its use as a diagnostic fluid

Biomarker Insights

Volumn 2008, Issue 3, 2008, Pages 25-37

  Esser, Diederik ^a   Alvarez Llamas, Gloria ^a   de Vries, Marcel ^a   Weening, Desiree ^a   Vonk, Roel J ^a   Roelofsen, Han ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Biomarkers; Mass spectrometry; Protein breakdown; Proteomics; Saliva; Sample stability

Indexed keywords

ACTIN; ADENINE PHOSPHORIBOSYLTRANSFERASE; ADENOSYLHOMOCYSTEINASE; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ALPHA ACTININ; ALPHA ENOLASE; ARGINASE; CALGRANULIN; CATHEPSIN D; CERULOPLASMIN; CLUSTERIN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; COMPLEMENT FACTOR H; CYSTATIN C; DERMCIDIN; DESMOCOLLIN; DESMOGLEIN 3; DIPEPTIDYL PEPTIDASE IV; DNA POLYMERASE; ELONGATION FACTOR 1ALPHA; EZRIN; KALLIKREIN; PROTEIN DNAK; PROTEINASE INHIBITOR; SALIVA PROTEIN; STEFIN A; STEFIN B;

ARTICLE; BACTERIAL METABOLISM; CONTROLLED STUDY; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MOLECULAR WEIGHT; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEOMICS; ROOM TEMPERATURE; SALIVA ANALYSIS; SAMPLING; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; TANDEM MASS SPECTROMETRY; UNINDEXED SEQUENCE;

BACTERIA (MICROORGANISMS);

EID: 39549089095     PISSN: None     EISSN: 11772719     Source Type: Journal    
DOI: 10.4137/bmi.s607     Document Type: Article

References (32)

1. Baum, B.J. 1993. Principles of seliva secretion. Ann. N. Y. Acad. Sci., 694:17-23.
2. Belazi, M.A., Galli-Tsinopoulou, A., Drakoulakos, D. et al. 1998. Salivary alterations in insulin-dependent diabetes mellitus. Int. J. Paediatr., Dent, 8:29-33.
3. Chicharro, J.L., Lucia, A., Perez, M. et al. 1998. Saliva composition and exercise. Sports Med., 26:17-27.
4. Dawes, C. 1993. Considerations in the development of diagnostic tests on saliva. Ann. N. Y. Acad Sci., 694:265-9.
5. Frerichs, R.R., Silarug, N., Eskes, N. et al. 1994. Saliva-based HIV-antibody testing in Thailand. AIDS, 8:885-94.
6. Guo, T., Rudnick, P.A., Wang, W. et al. 2006. Characterization of the human salivary proteome by capillary isoelectric focusing/ nanoreversed-phase liquid chromatography coupled with ESI-tandem MS. J. Proteome. Res., 5:1469-78.
7. Heine, R.P, McGregor, J.A., Goodwin, T.M. et al. 2000. Serial salivary estriol to detect an increased risk of preterm birth. Obstet. Gynecol., 96:490-7.
8. Helenius, L.M., Meurman, J.H., Helenius, I. et al. 200. Oral and salivary parameters in patients with rheumatic diseases. Acta Odontol. Scand, 63:284-93.
9. Holmstrom, P., Syrjanen, S., Laine, P. et al. 1990. HIV antibodies in whole saliva detected by ELISA and western blot assays. J. Med. Virol., 30:245-8.
10. Hu, S., Xie, Y., Ramachandran, P. et al. 2005. Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry. Proteomics, 5:1714-28.
11. Huang, C.M. 2004. Comparative proteomic analysis of human whole saliva. Arch. Oral. Biol., 49:951-62.
12. Imanguli, M.M., Atkinson, J.C., Harvey, K.E. et al. 2007. Changes in salivary proteome following allogeneic hematopoietic stem cell transplantation. Exp. Hematol., 35:184-192.
13. Kaufman, E. and Lamster, I.B. 2000. Analysis of saliva for periodontal diagnosis - a review. J. Clin. Periodontol., 27:453-65.
14. Kaufman, E. and Lamster, I.B. 2002. The diagnostic application of saliva - a review. Crit. Rev. Oral. Biol. Med., 13:197-212.
15. Lawrence, H.P. 2002. Salivary markers of systemic disease: noninvasive diagnosis of disease and monitoring of general health. J. Can. Dent. Assoc., 68:170-4.
16. Lenander-Lumikari, M., Ihalin, R. and Lahteenoja, H. 2000. Changes in whole saliva in patients with coeliac disease. Arch. Oral Biol., 45:347-54.
17. Lopez, M.E., Colloca, M.E., Paez, R.G. et al. 2003. Salivary characteristics of diabetic children. Braz. Dent. J., 14:26-31.
18. Malamud, D. 1992. Saliva as a diagnostic fluid. BMJ., 305:207-8.
19. Matsuda, S., Oka, S., Honda, M. et al. 1993. Characteristics of IgA antibodies against HIV-1 in sera and saliva from HIV-seropositive individuals in different clinical stages. Scand J. Immunol., 38:428-34.
20. Merchant, M. and Weinberger, S.R. 2000. Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry Electrophoresis, 21:1164-77.
21. Morris, M., Cohen, B., Andrews, N. et al. 2002. Stability of total and rubella-specific IgG in oral fluid samples: the effect of time and temperature. J. Immunol. Methods, 266:111-116.
22. Navazesh, M. 1993. Methods for collecting saliva. Ann. N. Y. Acad. Sci., 694:72-7.
23. Ng, V., Koh, D., Fu, Q. et al. 2003. Effects of storage time on stability of salivary immunoglobulin A and lysozyme. Clin. Chim. Acta., 338:131-134.
24. Ramsey, P.S. and Andrews, W.W. 2003. Biochemical predictors of preterm labor: fetal fibronectin and salivary estriol. Clin. Perinatol, 30:701-33.
25. Ryu, O.H., Atkinson, J.C., Hoehn, G.T. et al. 2006. Identification of parotid salivary biomarkers in Sjogren's syndrome by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry and two-dimensional difference gel electrophoresis. Rheumatology, 45: 1077-86.
26. Schipper, R, Loof, A., de Groot, J. et al. 2007. SELDI-TOF-MS of saliva: Methodology and pre-treatment effects. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 847:45-53.
27. Streckfus, C. and Bigler, L. 2005. The use of soluble, salivary c-erbB.-2 for the detection and post-operative follow-up of breast cancer in women: the results of a five-year translational research study. Adv. Dent. Res., 18:17-24.
28. Streckfus, C.F., Bigler, L.R. and Zwick, M. 2006. The use of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry to detect putative breast cancer markers in saliva: a feasibility study. J. Ordl Pathol. Med., 35:292-300.
29. Vitorino, R.,Lobo, M.J., Ferrer-Correira, A.J. et al. 2004. Idenfification of human whole saliva protein components using proteomics. Proteomics, 4:116-15.
30. Waz, A., Stuhler, K., Wattenberg, A. et al. 2006. Proteome analysis of glandular parotid and submandibular-sublingual saliva in comparison to whole human saliva by two-dimensional gel electrophoresis. Proteomics, 6:1631-39.
31. Wilmarth, P.A., Riviere, M.A., Rustvold, D.L. et al. 2004. Two-dimensional liquid chromatography study of the human whole saliva proteome. J. Proteome. Res., 3:1017-23.
32. Xie, H., Rhodus, N.L., Griffin, R.J. et al. 2005. A catalogue of human saliva proteins ideitified by free flow electrophoresis-based peptide separation and tandem mass spectrometry. Mol. Cell. Proteomics, 4:1826-30.