In Vivo Positive Contrast IRON Sequence and Quantitative T2* Measurement Confirms Inflammatory Burden in a Patient with Asymptomatic Carotid Atheroma after USPIO-enhanced MR Imaging

Journal of Vascular and Interventional Radiology

Volumn 19, Issue 3, 2008, Pages 446-448

  Howarth, Simon P S ^a,b,d   Li, Zhi Yong ^a,d   Tang, Tjun Y ^a,c,d   Graves, Martin J ^a,d   U King Im, Jean M ^a,d   Gillard, Jonathan H ^a,d  

^a University Department of Radiology   (United Kingdom)

^b Academic Department of Neurosurgery   (United Kingdom)

^c Cambridge Archaeological Unit   (United Kingdom)

^d CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; CONTRAST MEDIUM; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE;

ADULT; ARTICLE; ATHEROMA; CAROTID ARTERY OBSTRUCTION; CAROTID ENDARTERECTOMY; CASE REPORT; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; IN VIVO CULTURE; INFLAMMATION; INTERNAL CAROTID ARTERY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTPATIENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SMOKING;

CAROTID ARTERY DISEASES; CONTRAST MEDIA; COST OF ILLNESS; HUMANS; INFLAMMATION; IRON; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OXIDES;

EID: 39449126890     PISSN: 10510443     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvir.2007.11.019     Document Type: Article

References (14)

1. Hollander M., Bots M.L., Del Sol A.I., et al. Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly. the Rotterdam study. Circulation 105 (2002) 2872-2877
2. Rothwell P.M. Symptomatic and asymptomatic carotid stenosis: how, when, and who to treat?. Curr Atheroscler Rep 8 (2006) 290-297
3. North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 325 (1991) 445-453
4. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 351 (1998) 1379-1387
5. Luebke T., Aleksic M., and Brunkwall J. Meta-analysis of randomized trials comparing carotid endarterectomy and endovascular treatment. Eur J Vasc Endovasc Surg 34 (2007) 470-479
6. Kong Y.Z., Huang X.R., Ouyang X., et al. Evidence for vascular macrophage migration inhibitory factor in destabilization of human atherosclerotic plaques. Cardiovasc Res 65 (2005) 272-282
7. Newby A.C. Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. Physiol Rev 85 (2005) 1-31
8. Virmani R., Burke A.P., Kolodgie F.D., and Farb A. Vulnerable plaque: the pathology of unstable coronary lesions. J Interv Cardiol 15 (2002) 439-446
9. Yuan C., Mitsumori L.M., Beach K.W., and Maravilla K.R. Carotid atherosclerotic plaque: noninvasive MR characterization and identification of vulnerable lesions. Radiology 221 (2001) 285-299
10. Trivedi R.A., U-King-Im J.M., Graves M.J., et al. In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI. Stroke 35 (2004) 1631-1635
11. Stuber M. Shedding light on the dark spot with iron: a method that generates positive contrast in the presence of superparamagnetic nanoparticles. Proc Intl Soc Mag Reson Med 13 (2005) 2608
12. Stuber M. Shedding light on the dark spot with IRON: a method that generates positive contrast in the presence of superparamagnetic nanoparticles. Proc Intl Soc Magn Reson Med 13 (2005) 2608
13. Stuber M. Signal-enhanced visualization of magnetic nanoparticle-labeled stem cells using inversion recovery ON-resonant water suppression (IRON). Presented at the 2006 SCMR Annual Scientific Session, Miami, Fla. January 20 (2006)
14. Stuber M., Gilson W.D., Schar M., et al. Positive contrast visualization of iron oxide-labeled stem cells using inversion-recovery with ON-resonant water suppression (IRON). Magn Reson Med 58 (2007) 1072-1077