Interim treatment selection using the normal approximation approach in clinical trials

Statistics in Medicine

Volumn 27, Issue 4, 2008, Pages 597-618

  Shun, Zhenming ^a   Lan, K K Gordon ^b   Soo, Yuhwen ^a  

^a SANOFI   (France)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Adaptive design; Dose selection; Interim analysis; Multiplicity; Power; Sample size; Skewed normal distribution; Type I error; Winner design

Indexed keywords

ANALYTICAL ERROR; ARTICLE; CLINICAL RESEARCH; CONFIDENCE INTERVAL; MATHEMATICAL COMPUTING; NORMAL DISTRIBUTION; PROBABILITY; SAMPLE SIZE; STATISTICAL ANALYSIS; STUDENT T TEST;

ALGORITHMS; BIOMETRY; CLINICAL TRIALS AS TOPIC; HUMANS; TREATMENT OUTCOME;

EID: 39449115105     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.2990     Document Type: Article

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