Patulin influences the expression of Th1/Th2 cytokines by activated peripheral blood mononuclear cells and T cells through depletion of intracellular glutathione

Environmental Toxicology

Volumn 23, Issue 1, 2008, Pages 84-95

  Luft, Petra ^a   Oostingh, Gertie Janneke ^a   Gruijthuijsen, Yvonne ^a   Horejs Hoeck, Jutta ^a   Lehmann, Irina ^b   Duschl, Albert ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

^b HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

Author keywords

Cytokines; Glutathione; Patulin; Th1 Th2

Indexed keywords

HEALTHY DONORS; INTRACELLULAR GLUTATHIONE; PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC);

BIOASSAY; BLOOD; DISEASES; FUNGI; GENE EXPRESSION;

CELL CULTURE;

CD28 ANTIBODY; CD3 ANTIBODY; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 8; N ETHYLMALEIMIDE; PATULIN; STAUROSPORINE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

BLOOD; CYTOLOGY; FUNGUS; GENE EXPRESSION; HORMONE; SECRETION; TOXIN;

ALLERGENICITY; ALLERGIC DISEASE; ANTIBODY SPECIFICITY; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; ENVIRONMENTAL FACTOR; ENZYME LINKED IMMUNOSORBENT ASSAY; FOOD ALLERGY; FOOD INTAKE; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; INCUBATION TIME; INTRACELLULAR TRANSPORT; PENICILLIUM; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; TOXIN ANALYSIS;

CELL PROLIFERATION; CELL SURVIVAL; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUTATHIONE; HUMANS; LEUKOCYTES, MONONUCLEAR; MYCOTOXINS; PATULIN; PENICILLIUM; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS;

FUNGI; PENICILLIUM;

EID: 39449104781     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20309     Document Type: Article

References (32)

1. Akbari O, DeKruyff RH, Umetsu DT. 2001. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2:725-731.
2. Alves I, Oliveira NG, Laires A, Rodrigues AS, Rueff J. 2000. Induction of micronuclei and chromosomal aberrations by the mycotoxin patulin in mammalian cells: Role of ascorbic acid as a modulator of patulin clastogenicity. Mutagenesis 15:229-234.
3. Angelini G, Gardella S, Ardy M, Ciriolo MR, Filomeni G, Di Trapani G, Clarke F, Sitia R, Rubartelli A. 2002. Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation. Proc Natl Acad Sci USA 99:1491-1496.
4. Barhoumi R, Burghardt RC. 1996. Kinetic analysis of the chronology of patulin- and gossypol-induced cytotoxicity in vitro. Fundam Appl Toxicol 30:290-297.
5. Betina V. 1989. Structure-activity relationships among mycotoxins. Chem Biol Interact 71:105-146.
6. Bright JJ, Du C, Coon M, Sriram S, Klaus SJ. 1998. Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: An effect of the novel anti-inflammatory drug lisofylline. J Immunol 161:7015-7022.
7. Dickinson DA, Forman HJ. 2002. Cellular glutathione and thiols metabolism. Biochem Pharmacol 64:1019-1026.
8. Edinger AL, Thompson CB. 2002. Antigen-presenting cells control T cell proliferation by regulating amino acid availability. Proc Natl Acad Sci USA 99:1107-1109.
9. Fliege R, Metzler M. 1999. The mycotoxin patulin induces intra-and intermolecular protein crosslinks in vitro involving cysteine, lysine, and histidine side chains, and alpha-amino groups. Chem Biol Interact 123:85-103.
10. Fliege R, Metzler M. 2000. Electrophilic properties of patulin. N- acetylcysteine and glutathione adducts. Chem Res Toxicol 13:373-381.
11. Fraternale A, Paoletti MF, Casablanca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnami M. 2006. Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules. Curr Med Chem 13:1749-1755.
12. Frisvad JC, Thrane U, Samson RA, Pitt JI. 2006. Important mycotoxins and the fungi which produce them. Adv Exp Med Biol 571:3-31.
13. Fu CL, Ye YL, Lee YL, Chiang BL. 2006. Effects of overexpression of IL-10, IL-12, TGF-β and IL-4 on allergen induced change in bronchial responsiveness. Respir Res 7:72.
14. Griffith OW, Anderson ME, Meister A. 1979. Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of γ-glutamylcysteine synthetase. J Biol Chem 254:1205-1210.
15. Hadzic T, Li L, Cheng N, Walsh SA, Spitz DR, Knudson CM. 2005. The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion. J Immunol 175:7965-7972.
16. Herrick CA, Bottomly K. 2003. To respond or not to respond: T cells in allergic asthma. Nat Rev Immunol 3:405-412.
17. Liang CM, Lee N, Cattell D, Liang SM. 1989. Glutathione regulates interleukin-2 activity on cytotoxic T-cells. J Biol Chem 264:13519-13523.
18. Liu BH, Wu TS, Yu FY, Su CC. 2007. Induction of oxidative stress response by the mycotoxin patulin in mammalian cells. Toxicol Sci 95:340-347.
19. Liu BH, Wu TS, Yu FY, Wang CH. 2006. Mycotoxin patulin activates the p38 kinase and JNK signaling pathways in human embryonic kidney cells. Toxicol Sci 89:423-430.
20. Mahfoud R, Maresca M, Garmy N, Fantini J. 2002. The mycotoxin patulin alters the barrier function of the intestinal epithelium: Mechanism of action of the toxin and protective effects of glutathione. Toxicol Appl Pharmacol 181:209-218.
21. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
22. Murata Y, Amao M, Yoneda J, Hamuro J. 2002. Intracellular thiol redox status of macrophages directs the Th1 skewing in thioredoxin transgenic mice during aging. Mol Immunol 38:747-757.
23. Ohta N, Sakurai S, Yoshitake H, Aoyagi M. 2005. Analysis of Th1, Th2, Tc1 and Tc2 cells in patients with allergic rhinitis. Clin Exp Allergy Rev 5:68-71.
24. Panina-Bordignon P, Papi A, Mariani M, Di Lucia P, Casoni G, Bellettato C, Buonsanti C, Miotto D, Mapp C, Villa A, et al. 2001. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest 107:1357-1364.
25. Peterson JD, Herzenberg LA, Vasquez K, Waltenbaugh C. 1998. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc Natl Acad Sci USA 95:3071-3076.
26. Rahman I, MacNee W. 2000. Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J 16:534-554.
27. Schumacher DM, Metzler M, Lehmann L. 2005. Mutagenicity of the mycotoxin patulin in cultured Chinese hamster V79 cells, and its modulation by intracellular glutathione. Arch Toxicol 79:110-121.
28. Suthanthiran M, Anderson ME, Sharma VK, Meister A. 1990. Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc Natl Acad Sci USA 87:3343-3347.
29. Taylor A, Verhagen J, Blaser K, Akdis M, Akdis CA. 2006. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-β: The role of T regulatory cells. Immunology 117:433-442.
30. WHO. 1995. Evaluation of certain food additives and contaminants. World Health Organ Tech Rep Ser 859:1-54.
31. Wichmann G, Herbarth O, Lehmann I. 2002. The mycotoxins citrinin, gliotoxin, and patulin affect interferon-γ rather than interleukin-4 production in human blood cells. Environ Toxicol 17:211-218.
32. Wu D, Cederbaum A. 2004. Glutathione depletion in CYP2E1-expressing liver cells induces toxicity due to the activation of p38 mitogen-activated protein kinase and reduction of nuclear factor-κB DNA binding activity. Mol Pharmacol 66:749-760.