Quantitative method for the analysis of tobacco-specific nitrosamines in cigarette tobacco and mainstream cigarette smoke by use of isotope dilution liquid chromatography tandem mass spectrometry

Analytical Chemistry

Volumn 80, Issue 4, 2008, Pages 1341-1345

  Wu, Jingcun ^a   Joza, Peter ^a   Sharifi, Mehran ^a   Rickert, William S ^a   Lauterbach, John H ^b  

^a Labstat International ULC   (Canada)

^b Lauterbach and Associates LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ANALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ALGEBRA; TOBACCO;

MATRIX EFFECTS; QUANTIFICATION;

NITROSAMINES;

CIGARETTE SMOKE; NITROSAMINE; TOBACCO SMOKE;

ARTICLE; CIGARETTE SMOKING; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; ISOTOPE DILUTION ASSAY; ISOTOPE DILUTION LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; NONHUMAN; PHASE TRANSITION; PRODUCT RECOVERY; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; TOBACCO;

EID: 39449102982     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac702100c     Document Type: Article

References (13)

1. Wu, W.; Ashley, D. L.; Watson, C. H. Anal. Chem. 2003, 75, 4827-4832.
2. Wagner, K. A.; Finkel, N. H.; Fossett, J. E.; Gillman, I. G. Anal. Chem. 2005, 77, 1001-1006.
3. Lee, J.-M.; Shin, J.-W.; Oh, I.-H.; Lee, U.-C.; Rhee, M.-S. Determination of Tobacco Specific Nitrosamines in Mainstream Smoke of 2R4F Reference Cigarettes by LC/MS/MS. 2004 CORESTA Congress Kyoto, Kyoto, Japan, October 3-7, 2004; Paper SS20. Full text available on CORESTA CD-ROM Vol. 22; abstract available on the Internet at http://www.coresta.org/Past_Abstracts/Kyoto2004- SmokeTech.pdf (accessed December 29, 2006).
4. Chwojdak, C. A.; Self, D. A.; Wheeler, H. R. A Collaborative, Harmonized LC-MS/MS Method for the Determination of Tobacco Specific Nitrosamines (TSNA) in Tobacco and Tobacco Related Materials. 61st Tobacco Science Research Conference, Charlotte, NC,September 24, 2007.
5. Health Canada methods are available on the Internet at http://www.hcsc.gc.ca/hl-vs/tobac-tabac/legislation/reg/indust/method/index_e. html (accessed December 29, 2006).
6. Jessome, L. L.; Volmer, D. A. LCGC 2006, 24 (5), 498-510.
7. Guo, X.; Bruins, A. P.; Covey, T. R. Rapid Commun. Mass Spectrom. 2006, 20, 3145-3156.
8. Kebarle, P.; Tang, L. Anal. Chem. 1993, 65, 972A-984A.
9. McMaster, M. C. LC/MS: A Practical User's Guide; John Wiley & Sons: Hoboken, NJ, 2005.
10. Food and Drug Administration. Guidance for Industry on Bioanalytical Method Validation. Fed. Regist. 2001, 66 (100), 28526 (Docke No. 98D-1195).
11. Official Journal of the European Communities L221, 8-36. Commission Decision (2002/657/EC) of 12 August 2002 Concerning the Performance of Analytical Methods and the Interpretation of Results. Brussels, Belgium, 2002.
12. NIH Guidelines for the Laboratory Use of Chemical Carcinogens; NIH Publication 81-2385; U.S. Government Printing Office: Washington, DC, 1981.
13. th ed.; International Organization for Standardization: Geneva, Switzerland; pp. 1-4.