Protective efficacy of an aerosol preparation, obtained from Geranium sanguineum L., in experimental influenza infection

Pharmazie

Volumn 63, Issue 2, 2008, Pages 160-163

  Serkedjieva, Julia ^a,c   Gegova, G ^a   Mladenov, K ^b  

^a MILITARY MEDICAL ACADEMY   (Bulgaria)

^b BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

^c INSTITUTE OF MICROBIOLOGY   (Bulgaria)

Author keywords

[No Author keywords available]

Indexed keywords

GERANIUM SANGUINEUM EXTRACT; POLYPHENOL DERIVATIVE; UNCLASSIFIED DRUG;

AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GERANIUM; GERANIUM SANGUINEUM; INFLUENZA; INFLUENZA VIRUS A H3N2; LD 50; MALE; MOUSE; NONHUMAN; PLANT ROOT; PROPHYLAXIS; SURVIVAL TIME;

AEROSOLS; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CHICK EMBRYO; CYTOPATHOGENIC EFFECT, VIRAL; FEMALE; GERANIUM; INFLUENZA A VIRUS, H3N2 SUBTYPE; LETHAL DOSE 50; MALE; MICE; MICE, INBRED ICR; ORTHOMYXOVIRIDAE INFECTIONS; PLANT EXTRACTS; SURVIVAL ANALYSIS; SUSPENSIONS;

EID: 39449101434     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2008.7617     Document Type: Article

References (28)

1. Antonova-Nikolova S, Ivanova I, Ivancheva S, Tsvetkova R, Serkedjieva J (2002) Protease-inhibitory activity of a plant preparation with anti-influenza virus effect. In: Proceedings of Xth Congress of Bulgarian Microbiologists, Plovdiv, 9-12 October 2002, v. 1, pp. 358-362.
2. Che CT (1991) Plants as a source of potential antiviral agents. Econ Med Plant Res 5: 167-251.
3. Cottiglia F, Bonsignore L, Casu L, Deidda D, Pompei R, Casu M, Floris C (2005) Phenolic constituents from Ephedra nebrodensis. Nat Prod Res 19: 117-123.
4. Derebenzeva NA, Mishenkova EL, Garagulja OD (1972) Microbiologicheski J 34: 768-772 (in Ukrainian).
5. Droebner K, Ehrhardt C, Poetter A, Ludwig S, Planz O (2007) CYSTUS052, A polyphenol-rich plant extract, exerts anti-influenza virus activity in mice. Antiviral Res doi:10.1016/j.antiviral.2007.05.002.
6. Hamauzu Y, Yasui H, Inno T, Kume C, Omanyuda M (2005) Phenolic profile, antioxidant property, and anti-influenza viral activity of Chinese quince (Pseudocydonia sinensis Schneid.), quince (Cydonia oblonga Mill.), and apple (Malus domestica Mill.) fruits. J Agric Food Chem 53: 928-934.
7. Ivancheva S, Manolova N, Serkedjieva J, Dimov V, Ivanovska N (1992) Basic Life Sci 59: 717-729.
8. Ivancheva S, Stancheva B, Serkedjieva J (1996) Polyphenol compounds in Geranium sanguineum L. Comptes Rendus Bulgarian Acad Sci 49: 41-43.
9. Ivanova E, Toshkova R, Serkedjieva J (2005) A plant polyphenol-rich extract restores the suppressed functions of phagocytes in influenza virus-infected mice. Microbes and Infection 7: 391-398.
10. Libich J (1962) Effect of the administration of streptomycin in the incubation and manifest phase on the course of inhalation tularaemia in guinea pigs. Folia Microbiologica (Praha) 7: 320-325.
11. Naga, T, Miyaichi Y, Tomomori T, Suzuki Y, Yamada H (1992) In vivo antiinfluenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase. Antiviral Res 19: 207-219.
12. Nakayama M, Suzuki K, Toda M, Okubo S, Hara Y, Shimamura T (1993) Antiviral Res 21: 289-299.
13. Pantev A, Ivancheva S, Staneva L, Serkedjieva J (2006) Biologically active constituents of a polyphenol extract from Geranium sanguineum L. with antiviral activity. Z Naturforsch C 61c: 508-516.
14. Pollikoff R, Liberman M, Cochran KW, Pascale AM (1966) Effect of caffeic acid on mouse and ferret lung infected with influenza A virus. Antimicrob Agents Chemother 5: 561-566.
15. Rosebury T (1947) Experimental air-born infection. William and Wilkins Co., Baltimore.
16. Serkedjieva J, Manolova N (1992) A plant polyphenolic complex inhibits the reproduction of influenza and herpes simplex viruses. Basic Life Sci 59: 705-715.
17. Serkedjieva J (1995) Inhibition of influenza virus protein synthesis by a plant preparation from Geranium sanguineum L. Acta Virol 39: 5-10.
18. Serkedjieva J, Tonew EC (1996) Inhibitory effect of a plant preparation from Geranium sanguineum L. on virus specific RNA synthesis. Comptes Rendus Bulgarian Acad Sci 49: 73-76.
19. Serkedjieva J, Ivanova E (1997) Combined protective effect of an immunostimulatory bacterial preparation and rimantadine in experimental influenza A virus infection. Acta Virol 41: 65-70.
20. Serkedjieva J, Hay AJ (1998) In vitro anti-influenza virus activity of a plant preparation from Geranium sanguineum L. Antiviral Res 37: 221-230.
21. th Congress of Bulgarian Microbiologists, Plovdiv, 9-12 October 2002, v. 2, pp. 310-315.
22. Serkedjieva J (2003) Influenza virus variants with reduced susceptibility to inhibition with a polyphenol extract from Geranium sanguineum L. Pharmazie 58: 53-57.
23. Sidwell RW, Huffman JH, Moscon BJ, Warren RP (1994) Influenza virus-inhibitory effects of intraperitoneally and aerosol-administered SP-303, a plant flavonoid. Chemotherapy 40: 42-50.
24. Skwarek T (1979) Effect of plant extracts on the growth of influenza viruses. I. Effect of plant extracts on the growth of influenza viruses in cultures of chick embryo fibroblasts and in chick embryos. Acta Polon Pharmacol 36: 605-612 (in Polish).
25. Smee DF, Bailey KW, Sidwell RW (2000) Treatment of cowpox virus respiratory infections in mice with ribavirin as a single agent or followed sequentially by cidofovir. Antiviral Chem Chemother 11: 303-309.
26. Sokmen M, Angelova M, Krumova E, Pashova S, Ivancheva S, Sokmen A, Serkedjieva J (2005) In vitro antioxidant activity of a plant polyphenol extract with antiviral properties. Life Sci 76: 2981-2993.
27. Toshkova R Nikolova N, Ivanova E, Ivancheva S, Serkedjieva J (2004) In vitro investigation on the effect of a plant polyphenol extract with antiviral activity on the functions of mice phagocyte cells. Pharmazie 59: 150-154.
28. Vickanova, SA, Oifa AI, Gorjunova LV (1970) On the antiviral properties of gossipol in experimental influenza infection. Antibiotiki 12, 1071-1076 (in Russian).