World Health Organization classification of bone and soft tissue tumors: Modifications and implications for radiologists

Seminars in Musculoskeletal Radiology

Volumn 11, Issue 3, 2007, Pages 201-214

  Murphey, Mark D ^a,b  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Fibrosarcoma; Liposarcoma; Malignant fibrous histiocytoma; Soft tissue sarcoma; World Health Organization

Indexed keywords

BONE TUMOR; CANCER CLASSIFICATION; COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; CONSENSUS DEVELOPMENT; DIAGNOSTIC IMAGING; DIFFUSION WEIGHTED IMAGING; EVALUATION; HUMAN; IMAGE ANALYSIS; LANGUAGE; MALIGNANT FIBROUS HISTIOCYTOMA; MYXOSARCOMA; SOFT TISSUE TUMOR; WORLD HEALTH ORGANIZATION;

BONE NEOPLASMS; DIAGNOSTIC IMAGING; FIBROSARCOMA; HISTIOCYTOMA, BENIGN FIBROUS; HUMANS; LIPOSARCOMA; SOFT TISSUE NEOPLASMS; TERMINOLOGY AS TOPIC; WORLD HEALTH ORGANIZATION;

EID: 39449092758     PISSN: 10897860     EISSN: 1098898X     Source Type: Journal    
DOI: 10.1055/s-2008-1038310     Document Type: Conference Paper

References (82)

1. Fletcher D, Unni K, Mertens F. Liposarcoma of Bone. In: World Health Organization Classification of Tumors. Pathology & Genetics of Tumour of Soft Tissue and Bone. Lyon: IARC Press; 2002:330
2. Fletcher CD. Pleomorphic malignant fibrous histiocytoma: fact or fiction? A critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma. Am J Surg Pathol 1992;16:213-228
3. Fletcher CD, Gustafson P, Rydholm A, Willen H, Akerman M. Clinicopathologic re-evaluation of 100 malignant fibrous histiocytomas: prognostic relevance of subclassification. J Clin Oncol 2001;19:3045-3050
4. Rosenberg AE. Malignant fibrous histiocytoma: past, present, and future. Skeletal Radiol 2003;32:613-618
5. Salo JC, Lewis JJ, Woodruff JM, Leung DH, Brennan MF. Malignant fibrous histiocytoma of the extremity. Cancer 1999;85:1765-1772
6. Bertoni F, Capanna R, Biagini R, et al. Malignant fibrous histiocytoma of soft tissue. An analysis of 78 cases located and deeply seated in the extremities. Cancer 1985;56:356-367
7. Enzinger FM. Malignant fibrous histiocytoma 20 years after Stout. Am J Surg Pathol 1986;10(Suppl 1):43-53
8. Gibbs JF, Huang PP, Lee RJ, et al. Malignant fibrous histiocytoma: an institutional review. Cancer Invest 2001;19:23-27
9. Miettinen M. Malignant and potentially malignant fibroblastic and myofibroblastic tumors. In: Diagnostic Soft Tissue Pathology. New York: Churchill Livingstone; 2003:189-206
10. Kearney MM, Soule EH, Ivins JC. Malignant fibrous histiocytoma: a retrospective study of 167 cases. Cancer 1980;45:167-178
11. Fletcher C, Unni K, Mertens F. World Health Organization Classification of tumors. Pathology and genetics of tumors of soft tissue and bone. Lyon, France: IARC Press; 2002
12. Antonescu CR, Rosenblum MK, Pereira P, Nascimento AG, Woodruff JM. Sclerosing epithelioid fibrosarcoma: a study of 16 cases and confirmation of a clinicopathologically distinct tumor. Am J Surg Pathol 2001;25:699-709
13. Weiss SW, Goldblum JR. Fibrosarcoma. In: Strauss M, ed. Soft Tissue Tumors. 4th ed. St. Louis: Mosby; 2001:409-440
14. Weiss SW, Goldblum JR. Malignant fibrohistiocytic tumors. In: Strauss M, ed. Soft Tissue Tumors. 4th ed. St. Louis: Mosby; 2001:535-570
15. Evans HL. Low-grade fibromyxoid sarcoma. A report of two metastasizing neoplasms having a deceptively benign appearance. Am J Clin Pathol 1987;88:615-619
16. Evans HL. Low-grade fibromyxoid sarcoma. A report of 12 cases. Am J Surg Pathol 1993;17:595-600
17. Fetsch JF, Laskin WB, Miettinen M. Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes. Hum Pathol 2001;32:704-714
18. Jurcic V, Zidar A, Montiel MD, et al. Myxoinflammatory fibroblastic sarcoma: a tumor not restricted to acral sites. Ann Diagn Pathol 2002;6:272-280
19. Kempson R, Fletcher C, Evans H, Hendrickson M, Sibley R. Fibrous and myofibroblastic tumors. In: Rosai J, ed. Tumors of the Soft Tissues. 3rd ed. Bethesda, MD: Armed Forces Institute of Pathology; 2001:23-112
20. Kyriakos M, Kempson RL. Inflammatory fibrous histiocytoma. An aggressive and lethal lesion. Cancer 1976;37:1584-1606
21. Lambert I, Debiec-Rychter M, Guelinckx P, Hagemeijer A, Sciot R. Acral myxoinflammatory fibroblastic sarcoma with unique clonal chromosomal changes. Virchows Arch 2001;438:509-512
22. Le Doussal V, Coindre JM, Leroux A, et al. Prognostic factors for patients with localized primary malignant fibrous histiocytoma: a multicenter study of 216 patients with multivariate analysis. Cancer 1996;77:1823-1830
23. Meis-Kindblom JM, Kindblom LG. Acral myxoinflammatory fibroblastic sarcoma: a low-grade tumor of the hands and feet. Am J Surg Pathol 1998;22:911-924
24. Meis-Kindblom JM, Kindblom LG, Enzinger FM. Sclerosing epithelioid fibrosarcoma. A variant of fibrosarcoma simulating carcinoma. Am J Surg Pathol 1995;19:979-993
25. Mentzel T, Dry S, Katenkamp D, Fletcher CD. Low-grade myofibroblastic sarcoma: analysis of 18 cases in the spectrum of myofibroblastic tumors. Am J Surg Pathol 1998;22:1228-1238
26. Montgomery E, Devaney KO, Weiss SW. Low-grade fibroblastic sarcomas and their distinction from deep fibromatoses. Mod Pathol 1996;9:42A
27. Montgomery E, Fisher C. Myofibroblastic differentiation in malignant fibrous histiocytoma (pleomorphic myofibrosarcoma): a clinicopathological study. Histopathology 2001;38:499-509
28. Montgomery E, Goldblum JR, Fisher C. Myofibrosarcoma: a clinicopathologic study. Am J Surg Pathol 2001;25:219-228
29. Montgomery EA, Devaney KO, Giordano TJ, Weiss SW. Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells: a distinctive lesion with features simulating inflammatory conditions, Hodgkin's disease, and various sarcomas. Mod Pathol 1998;11:384-391
30. Tateishi U, Hasegawa T, Onaya H, Satake M, Arai Y, Moriyama N. Myxoinflammatory fibroblastic sarcoma: MR appearance and pathologic correlation. AJR Am J Roentgenol 2005;184:1749-1753
31. Kransdorf MJ. Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol 1995;164:129-134
32. Kransdorf MJ, Murphey MD. Malignant fibrous and fibrohistiocytic tumors. In: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2006: 157-197
33. Murphey MD, Gross TM, Rosenthal HG. From the archives of the AFIP. Musculoskeletal malignant fibrous histiocytoma: Radiologic-pathologic correlation. Radiographics 1994;14:807-826 quiz 827-808
34. Fischer HJ, Lois JF, Gomes AS, Mirra JM, Deutsch LS. Radiology and pathology of malignant fibrous histiocytomas of the soft tissues: a report of ten cases. Skeletal Radiol 1985;13:202-206
35. Mahajan H, Kim EE, Wallace S, Abello R, Benjamin R, Evans HL. Magnetic resonance imaging of malignant fibrous histiocytoma. Magn Reson Imaging 1989;7:283-288
36. Miller TT, Hermann G, Abdelwahab IF, Klein MJ, Kenan S, Lewis MM. MRI of malignant fibrous histiocytoma of soft tissue: analysis of 13 cases with pathologic correlation. Skeletal Radiol 1994;23:271-275
37. Dorfman HD, Bhagavan BS. Malignant fibrous histiocytoma of soft tissue with metaplastic bone and cartilage formation: a new radiologic sign. Skeletal Radiol 1982;8:145-150
38. Christensen DR, Ramsamooj R, Gilbert TJ. Sclerosing epithelioid fibrosarcoma: short T2 on MR imaging. Skeletal Radiol 1997;26:619-621
39. Lin J, Jacobson JA, Fessell DP, Weadock WJ, Hayes CW. An illustrated tutorial of musculoskeletal sonography: Part 4, musculoskeletal masses, sonographically guided interventions, and miscellaneous topics. AJR Am J Roentgenol 2000;175:1711-1719
40. Panicek DM, Casper ES, Brennan MF, Hajdu SI, Heelan RT. Hemorrhage simulating tumor growth in malignant fibrous histiocytoma at MR imaging. Radiology 1991;181:398-400
41. Rooser B, Willen H, Gustafson P, Alvegard TA, Rydholm A. Malignant fibrous histiocytoma of soft tissue. A population-based epidemiologic and prognostic study of 137 patients. Cancer 1991;67:499-505
42. Zagars GK, Mullen JR, Pollack A. Malignant fibrous histiocytoma: outcome and prognostic factors following conservation surgery and radiotherapy. Int J Radiat Oncol Biol Physiol 1996;34:983-994
43. Weiss SW, Enzinger FM. Malignant fibrous histiocytoma: an analysis of 200 cases. Cancer 1978;41:2250-2266
44. Christopher D, Unni K, Mertens F. Adipocytic tumors. In: WHO classification of tumors. Pathology and genetics: tumors of soft tissue and bone. Lyon, France: IARC Press; 2002:19-46
45. Dei Tos AP. Liposarcoma: new entities and evolving concepts. Ann Diagn Pathol 2000;4:252-266
46. Kempson R, Fletcher CD, Evans HL, Hendrickson MR, Sibley R. Malignant lipomatous tumors. In: Atlas of Tumor Pathology: Tumor of the Soft Tissue. Washington, DC: Armed Forces Institute of Pathology; 2001:17-238
47. Kransdorf MJ, Murphey MD. Lipomatous tumors. In: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2006:80-149
48. Murphey MD, Arcara LK, Fanburg-Smith J. From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation. Radiographics 2005;25:1371-1395
49. Evans HL. Liposarcoma: a study of 55 cases with a reassessment of its classification. Am J Surg Pathol 1979;3:507-523
50. Evans HL, Soule EH, Winkelmann RK. Atypical lipoma, atypical intramuscular lipoma, and well differentiated retroperitoneal liposarcoma: a reappraisal of 30 cases formerly classified as well differentiated liposarcoma. Cancer 1979;43:574-584
51. Evans H. Liposarcomas and atypical lipomatous tumors: a study of 66 cases followed for a minimum of 10 years. Surg Pathol 1988;1:41-54
52. Weiss S, Goldblum J. Liposarcoma. In: Enzinger and Weiss's Soft Tissue Tumors. 4th ed. St. Louis: CV Mosby; 2001:641-693
53. Arkun R, Memis A, Akalin T, Ustun EE, Sabah D, Kandiloglu G. Liposarcoma of soft tissue: MRI findings with pathologic correlation. Skeletal Radiol 1997;26:167-172
54. Gaskin CM, Helms CA. Lipomas, lipoma variants, and well-differentiated liposarcomas (atypical lipomas): results of MRI evaluations of 126 consecutive fatty masses. AJR Am J Roentgenol 2004;182:733-739
55. Jelinek JS, Kransdorf MJ, Shmookler BM, Aboulafia AJ, Malawer MM. Liposarcoma of the extremities: MR and CT findings in the histologic subtypes. Radiology 1993;186:455-459
56. Kransdorf MJ, Moser RP Jr, Meis JM, Meyer CA. Fat-containing soft-tissue masses of the extremities. Radiographics 1991;11:81-106
57. Munk PL, Lee MJ, Janzen DL, et al. Lipoma and liposarcoma: evaluation using CT and MR imaging. AJR Am J Roentgenol 1997;169:589-594
58. Peterson JJ, Kransdorf MJ, Bancroft LW, O'Connor MI. Malignant fatty tumors: classification, clinical course, imaging appearance and treatment. Skeletal Radiol 2003;32:493-503
59. Kransdorf MJ, Bancroft LW, Peterson JJ, Murphey MD, Foster WC, Temple HT. Imaging of fatty tumors: distinction of lipoma and well-differentiated liposarcoma. Radiology 2002;224:99-104
60. Murphey MD, Carroll JF, Flemming DJ, Pope TL, Gannon FH, Kransdorf MJ. From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics 2004;24:1433-1466
61. Ohguri T, Aoki T, Hisaoka M, et al. Differential diagnosis of benign peripheral lipoma from well-differentiated liposarcoma on MR imaging: is comparison of margins and internal characteristics useful? AJR Am J Roentgenol 2003;180(6):1689-1697
62. Hosono M, Kobayashi H, Fujimoto R, et al. Septum-like structures in lipoma and liposarcoma: MR imaging and pathologic correlation. Skeletal Radiol 1997;26(3):150-154
63. Enzinger FM, Winslow DJ. Liposarcoma. A study of 103 cases. Virchows Arch Pathol Anat Physiol Klin Med 1962;335:367-388
64. Lucas DR, Nascimento AG, Sanjay BK, Rock MG. Well-differentiated liposarcoma. The Mayo Clinic experience with 58 cases. Am J Clin Pathol 1994;102:677-683
65. Reszel PA, Soule EH, Coventry MB. Liposarcoma of the extremities and limb girdles. A study of two hundred twenty-two cases. J Bone Joint Surg Am 1966;48:229-244
66. Weiss SW, Rao VK. Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites. A follow-up study of 92 cases with analysis of the incidence of "dedifferentiation." Am J Surg Pathol 1992;16:1051-1058
67. McCormick D, Mentzel T, Beham A, Fletcher CD. Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. Am J Surg Pathol 1994;18:1213-1223
68. Kilpatrick SE, Doyon J, Choong PF, Sim FH, Nascimento AG. The clinicopathologic spectrum of myxoid and round cell liposarcoma. A study of 95 cases. Cancer 1996;77:1450-1458
69. Lindahl S, Markhede G, Berlin O. Computed tomography of lipomatous and myxoid tumors. Acta Radiol Diagn (Stockh) 1985;26:709-713
70. London J, Kim EE, Wallace S, Shirkhoda A, Coan J, Evans H. MR imaging of liposarcomas: correlation of MR features and histology. J Comput Assist Tomogr 1989;13:832-835
71. Peterson KK, Renfrew DL, Feddersen RM, Buckwalter JA, el-Khoury GY. Magnetic resonance imaging of myxoid containing tumors. Skeletal Radiol 1991;20:245-250
72. Behan M, Kazam E. The echographic characteristics of fatty tissues and tumors. Radiology 1978;129:143-151
73. Sung MS, Kang HS, Suh JS, et al. Myxoid liposarcoma: appearance at MR imaging with histologic correlation. Radiographics 2000;20:1007-1019
74. Murphey M, Flemming D, Jelinek J, Temple H, Levine A, Torop A. Imaging of higher grade liposarcoma with pathologic correlation. Radiology 1997;205(P):332
75. Bancroft LW, Kransdorf MJ, Menke DM, O'Connor MI, Foster WC. Intramuscular myxoma: characteristic MR imaging features. AJR Am J Roentgenol 2002;178:1255-1259
76. Murphey MD, McRae GA, Fanburg-Smith JC, Temple HT, Levine AM, Aboulafia AJ. Imaging of soft-tissue myxoma with emphasis on CT and MR and comparison of radiologic and pathologic findings. Radiology 2002;225:215-224
77. Tateishi U, Hasegawa T, Beppu Y, Kawai A, Satake M, Moriyama N. Prognostic significance of MRI findings in patients with myxoid-round cell liposarcoma. AJR Am J Roentgenol 2004;182:725-731
78. Smith TA, Easley KA, Goldblum JR. Myxoid/round cell liposarcoma of the extremities. A clinicopathologic study of 29 cases with particular attention to extent of round cell liposarcoma. Am J Surg Pathol 1996;20:171-180
79. Oliveira AM, Nascimento AG. Pleomorphic liposarcoma. Semin Diagn Pathol 2001;18:274-285
80. Eilber FC, Eilber FR, Eckardt J, et al. The impact of chemotherapy on the survival of patients with high-grade primary extremity liposarcoma. Ann Surg 2004;240:686-695; discussion 695-687
81. Gebhard S, Coindre JM, Michels JJ, et al. Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol 2002;26:601-616
82. Hornick JL, Bosenberg MW, Mentzel T, McMenamin ME, Oliveira AM, Fletcher CD. Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. Am J Surg Pathol 2004;28:1257-1267