Simultaneous characterization of aerodynamic size and electrostatic charge distributions of inhaled dry powder inhaler aerosols

Current Respiratory Medicine Reviews

Volumn 4, Issue 1, 2008, Pages 2-5

  Ali, Mohammed ^a,b   Reddy, Rama N ^b   Mazumder, Malay K ^b  

^a Jackson State University   (United States)

^b University of Arkansas   (United States)

Author keywords

Aerodynamic size; DPI aerosol; Electrostatic charge; Laser doppler velocimetry

Indexed keywords

BUDESONIDE; FLUTICASONE PROPIONATE PLUS SALMETEROL; LACTOSE; TIOTROPIUM BROMIDE;

AEROSOL; ANALYZER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRY POWDER; ELECTRICITY; ELECTRONIC SINGLE PARTICLE AERODYNAMIC RELAXATION TIME ANALYZER; EQUIPMENT DESIGN; IN VITRO STUDY; MEASUREMENT; PARTICLE SIZE; POWDER INHALER; PRIORITY JOURNAL; REVIEW;

EID: 39449092024     PISSN: 1573398X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339808783497819     Document Type: Review

References (14)

1. Hinds WC. Aerosol Technology: properties, behavior and measurement of airborne particles, John Wiley & Sons Inc., New York; 1998.
2. Finlay WH. The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Academic Press, San Diego; 2001.
3. Staniforth JN. The importance of electrostatic measurements in aerosol formulation and pre-formulation, Byron PR, Dalby RN, and Farr SJ, (eds), Respiratory Drug Delivery IV, Interperm Press, Deerfield, IL, 1994; 4: 303-311.
4. Yu CP. Precipitation of unipolarly charged particles in cylindrical and spherical vessel. J Aerosol Sci 1977; 8: 237-241.
5. Melandri C, Tarroni G, Prodi V, Zaiacomo TD, Formignani M, Lombardi C. Deposition of charged particles in the human airways. J Aerosol Sc 1983; 14(5): 657-669.
6. Hashish AH, Bailey AG, Williams TJ. Selective deposition of pulsed charged aerosols in the human lung. J Aerosol Med 1994; 7(2): 167-171.
7. Balachandran W. Control of drug aerosol in human airways using electrostatic forces. J Electrostatics 1997; 40-41: 579-584.
8. Cohen BS, Xiong JQ, Fang CP, Li W. Deposition of charged particles on lung airways. Health Phys 1998; 74(5): 554-560.
9. Bailey AG, Hashish AH, Williams TJ. Drug delivery by inhalation of charged puticles. J Electrostatics 1998; 44: 3-10.
10. Peart J, Kulphaisal P, Orban JC. Relevance of electrostatics in respiratory drug delivery. Business Briefing: Pharmagenerics 2003; 84-87.
11. Glover W, Chan HK. Electrostatic charge characterization of pharmaceutical aerosols using electrical low-power impaction (ELPI). J Aerosol Sci 2003; 35: 755-764.
12. Mazumder MK, Ware RE. Aerosol particles charge and size analyzer. US Patent # 4633714, 1987.
13. Mazumder MK, Wilson JD, Wankum DL, et al. Dual laser doppler system for real-time simultaneous characterization of aerosols by size and concentration. In Lung Dosimetry, ed. Crapo JD, San Diego: Academic Press 1989; 211-234.
14. Cheng YS. Modeling aerosol drug delivery. Gradon L, Marijnissen J. (eds), Optimization of Aerosol Drug Delivery, Boston: Kluwer Academic Publishers 2003: 165-188.