L-proline-mediated one-pot synthesis of 3-exomethylene β-lactams via Kinugasa reaction

Synlett

Volumn , Issue 9, 2004, Pages 1637-1639

  Basak, Amit ^a   Ghosh, Subhash Chandra ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Amino acids; Isoxazoline; Kinugasa reaction; Proline; lactams

Indexed keywords

ALCOHOL DERIVATIVE; BETA LACTAM DERIVATIVE; COPPER; NITRONE DERIVATIVE; PROLINE;

ARTICLE; CHEMICAL REACTION; CYCLOADDITION; KINUGASA REACTION; SYNTHESIS;

EID: 3943057458     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-829097     Document Type: Article

References (18)

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16. 2O and filtered through celite. The celite bed was washed with EtOAc. The combined filtrate and washings were extracted with EtOAc. The residue, obtained after evaporation, afforded a mixture of exo-methylene β-lactam and the cis-β-lactam. These two were easily separated by column chromatography over silica gel using hexane-EtOAc (4:1) as eluent.
17. 2a
18. All the nitrones were prepared according to the procedure described: Bhattacharya, G. Ph. D. Thesis; Indian Institute of Technology: Kharagpur India, 1997.