Allosteric modulation: A novel approach to drug discovery

Innovations in Pharmaceutical Technology

Volumn , Issue 24, 2007, Pages

  Epping Jordan, Mark P ^a   Le Poul, Emmanuel ^a   Rocher, Jean Philippe ^a  

^a ADDEX PHARMACEUTICALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 FLUOROPHENYL [3 [3 (4 FLUOROUPHENYL) [1,2,4]OXADIAZOL 5 YL]PIPERIDIN 1 YL] METHANONE; ACETYLCHOLINE; ADX 47273; ARIPIPRAZOLE; DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 5; LIGAND; METABOTROPIC RECEPTOR AGONIST; NEW DRUG; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; DRUG ACTIVITY; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EXTRAPYRAMIDAL SYMPTOM; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN GENOME; HYPERPROLACTINEMIA; PHARMACOPHORE; PROTEIN FAMILY; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

EID: 39349118221     PISSN: 14717204     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (3)

1. Foord S, Receptor classification: post genome, Curr Opin Pharmacol 2, p561, 2006
2. Christopoulos A, Allosteric binding sites on cell-surface receptors: novel targets for drug discovery, Nat Rev Drug Discov 1, ppl98-210, 2002
3. May LT, Leach K, Sexton PM and Christopoulos A, Allosteric modulation of G protein-coupled receptors, Annu Rev Pharmacol Toxicol 47, pp1-51, 2007