Associations of serum sex hormone binding globulin (SHBG) levels with SHBG gene polymorphisms in the CARDIA male hormone study

American Journal of Epidemiology

Volumn 167, Issue 4, 2008, Pages 412-418

  Turk, Andrew ^a   Kopp, Peter ^b   Colangelo, Laura A ^b   Urbanek, Margrit ^b   Wood, Kent ^c   Liu, Kiang ^b   Skinner, Halcyon G ^d   Gapstur, Susan M ^b  

^a Columbia University ^*  (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Men; Polymorphism, genetic; Sex hormone binding globulin

Indexed keywords

SEX HORMONE BINDING GLOBULIN;

GENE; HEALTH RISK; MALE; MEASUREMENT METHOD; POLYMORPHISM; SERUM; SEX HORMONE; SEX-RELATED DIFFERENCE;

ADULT; ARTICLE; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; MULTIVARIATE ANALYSIS; PROTEIN BLOOD LEVEL; SEX HORMONE BINDING GLOBULIN GENE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; TIME SERIES ANALYSIS;

ADULT; AFRICAN AMERICANS; ALLELES; ANDROGEN-BINDING PROTEIN; BIOLOGICAL MARKERS; CORONARY ARTERY DISEASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LONGITUDINAL STUDIES; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; SEX HORMONE-BINDING GLOBULIN; UNITED STATES;

EURASIA; EUROPE; NORTHERN EUROPE; SCANDINAVIA;

EID: 39349114944     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwm332     Document Type: Article

References (18)

1. Westphal U. Steroid-protein interactions II. Monogr Endocrinol 1986;27:1-603.
2. Bérubé D, Séralini GE, Gagné R, et al. Localization of the human sex hormone-binding globulin gene (SHBG) to the short arm of chromosome 17 (17p12→p13). Cytogenet Cell Genet 1990;54:65-7.
3. Hammond GL, Underhill DA, Smith CL, et al. The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain. FEBS Lett 1987;215:100-4.
4. Hammond GL, Underhill DA, Rykse HM, et al. The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs. Mol Endocrinol 1989;3:1869-76.
5. Walsh KA, Titani K, Takio K, et al. Amino acid sequence of the sex steroid binding protein of human blood plasma. Biochemistry 1986;25:7584-90.
6. Avvakumov GV, Matveentseva IV, Akhrem LV, et al. Study of the carbohydrate moiety of human serum sex hormone-binding globulin. Biochim Biophys Acta 1983;760:104-10.
7. Power SG, Bocchinfuso WP, Pallesen M, et al. Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain. J Clin Endocrinol Metab 1992;75:1066-70.
8. Cousin P, Dechaud H, Grenot C, et al. Human variant sex hormone-binding globulin (SHBG) with an additional carbohydrate chain has a reduced clearance rate in rabbit. J Clin Endocrinol Metab 1998;83:235-40.
9. Larrea F, Oliart RM, Granados J, et al. Genetic polymorphism of the human sex hormone-binding globulin: evidence of an isoelectric focusing variant with normal androgen-binding affinities. J Steroid Biochem 1990;36:541-8.
10. Van Baelen H, Convents R, Cailleau J, et al. Genetic variation of human sex hormone-binding globulin: evidence for a worldwide bi-allelic gene. J Clin Endocrinol Metab 1992;75:135-9.
11. Hogeveen KN, Talikka M, Hammond GL. Human sex hormone-binding globulin promoter activity is influenced by a (TAAAA)n repeat element within an Alu sequence. J Biol Chem 2001;276:36383-90.
12. n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels. J Clin Endocrinol Metab 2003;88:5976-80.
13. Cousin P, Calemard-Michel L, Lejeune H, et al. Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women. J Clin Endocrinol Metab 2004;89:917-24.
14. Haiman CA, Riley SE, Freedman ML, et al. Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating SHBG levels among postmenopausal women: The Multiethnic Cohort. J Clin Endocrinol Metab 2005;90:2198-204.
15. Dunning AM, Dowsett M, Healey CS, et al. Polymorphisms associated with circulating sex hormone levels in postmenopausal women. J Natl Cancer Inst 2004;96:936-45.
16. Eriksson AL, Lorentzon M, Mellström D, et al. SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density. J Clin Endocrinol Metab 2006;91:5029-37.
17. Friedman GD, Cutter GR, Donahue RP, et al. CARDIA: study design, recruitment, and some characteristics of the examined subjects. J Clin Epidemiol 1988;41:1105-16.
18. Gapstur SM, Gann PH, Kopp P, et al. Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA Male Hormone Study. Cancer Epidemiol Biomarkers Prev 2002;11:1041-7.