Validation of a simple HPLC method for assay of haplamine and its metabolites in plasma suitable for pharmacokinetic application in rats

Biomedical Chromatography

Volumn 22, Issue 2, 2008, Pages 125-130

  Ea, Sompheary ^a   Aubert, Claucle ^a   Giacometti, Sarah ^a   Ciccolini, Joseph ^a   Siv, Chhan ^b   Bun, Hot ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b CNRS   (France)

Author keywords

Haplamine; HPLC; Pharmacokinetics; Plasma; Trans cis 3,4 dihydroxyhaplamine

Indexed keywords

METABOLITES; PHARMACOKINETICS;

HAPLAMINE; HPLC; HPLC METHOD; LIQUID-LIQUID EXTRACTION; PHARMACOKINETIC STUDIES; SIMPLE++; SIMULTANEOUS DETERMINATIONS; TRANS/CIS-3,4-DIHYDROXYHAPLAMINE; ULTRA VIOLET DETECTION; ULTRAVIOLET DETECTION;

RATS;

3,4 DIHYDROXYHAPLAMINE; ACETONITRILE; ALKALOID DERIVATIVE; DRUG METABOLITE; HAPLAMINE; METHANOL; UNCLASSIFIED DRUG; WATER;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CALIBRATION; CONTROLLED STUDY; CORRELATION COEFFICIENT; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG METABOLISM; EMULSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MEAN RESIDENCE TIME; NONHUMAN; RAT; ULTRAVIOLET SPECTROSCOPY; VALIDATION PROCESS; WISTAR RAT;

NAUTILUS; RATTUS;

EID: 39349114753     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.904     Document Type: Article

References (8)

1. Akhmedjanova VI, Bessonova IA and Yunusov S Yu. Alkaloids of Haplophyllum perforatum. Khimiya Prirodnykh Soedinenii 1976; 3: 320-328.
2. Cantrell CL, Schrader KK, Mamonov LK, Sitpaeva GT, Kustova TS, Dumbar C and Wedge DE. Isolation and identification of antifungal and antialgal alkaloids from Haplophyllum sieversii. Journal of Agricultural Food Chemistry 2005; 53: 7741-7718.
3. Ea S, Bun SS, Aubert C, Akhmedjanova V, Olivier E, Siv C and Bun H. Inter-species variability of haplamine metabolism and identification of its phase I metabolites from liver microsomes. Planta Medica 2006; 72: 1273-1278.
4. ICH Q2B. Validation of Analytical Procedures: Methodology. The European Agency for the Evaluation of Medical Products: London, 1996.
5. Jansen O, Akhmedjanova V, Angenot L, Balansard G, Chariot A, Ollivier E, Tits M and Frédérich M. Screening of 14 alkaloids isolated from Haplophyllum A. Juss for their cytotoxic properties. Journal of Ethnopharmacology 2006; 105: 241-245.
6. Shabir GA. Validation of high-performance liquid chromatography methods for pharmaceutical analysis. Understanding the differences and similarities between validation requirements of the US Food and Drug Administration, the US Pharmacopeia and the International Conference on Harmonization. Journal of Chromatography A 2003; 987: 57.
7. Shah VP, Midha KK, Dighe S, Mcgliveray, JJ, Skelly IJ, Skelly JP, Jacobi TA, Layoff T, Viswanathan CT, Cook, CE, Mc Dowall RD, Pittman KA and Spector S. Analytical methods validation: bioavailability, bioequivalence and pharmacokinetic studies. Journal of Pharmaceutical Sciences 1992; 81: 309.
8. United States Pharmacopeia. United States Pharmacopeial Convention: Rockville, MD, 1995; 1982.