메뉴 건너뛰기




Volumn 46, Issue 1, 2008, Pages 96-100

The risks and incidence of K65R and L74V mutations and subsequent virologic responses

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE INHIBITOR;

EID: 39349113994     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/523001     Document Type: Article
Times cited : (13)

References (29)
  • 1
    • 39349084624 scopus 로고    scopus 로고
    • Bartlett JA, Fath M, DeMasi R, et al. An updated meta-analysis of triple combination therapy in antiretroviral-naive HIV-infected adults [abstract 586]. In: Program and abstracts of the 12th Conference on Retroviruses and Opportunistic Infections (Boston). Alexandria, VA: Foundation for Retrovirology and Human Health, 2005.
    • Bartlett JA, Fath M, DeMasi R, et al. An updated meta-analysis of triple combination therapy in antiretroviral-naive HIV-infected adults [abstract 586]. In: Program and abstracts of the 12th Conference on Retroviruses and Opportunistic Infections (Boston). Alexandria, VA: Foundation for Retrovirology and Human Health, 2005.
  • 2
    • 34250164176 scopus 로고    scopus 로고
    • Rise and fall of the RT K65R incidence in the Portugese resistance database [abstract 121]
    • Camacho R, Theys K, Abecasis A, et al. Rise and fall of the RT K65R incidence in the Portugese resistance database [abstract 121]. Antivir Ther 2006; 11:S134.
    • (2006) Antivir Ther , vol.11
    • Camacho, R.1    Theys, K.2    Abecasis, A.3
  • 3
    • 9244234943 scopus 로고    scopus 로고
    • Effect of concurrent zidovidine use on the resistance pathways selected by abvacavir-containing regimens
    • Lanier ER, Givens N, Stone C, et al. Effect of concurrent zidovidine use on the resistance pathways selected by abvacavir-containing regimens. HIV Med 2004; 4:394-9.
    • (2004) HIV Med , vol.4 , pp. 394-399
    • Lanier, E.R.1    Givens, N.2    Stone, C.3
  • 4
    • 39349084981 scopus 로고    scopus 로고
    • Underwood M, St Clair M, Ross L, et al. Cross-resistance of clinical samples with K65R, L74V, and M184V mutations [abstract 714]. In: Program and abstracts of the 12th Conference on Retroviruses and Opportunistic Infections (Boston). Alexandria, VA: Foundation for Retrovirology and Human Health, 2005.
    • Underwood M, St Clair M, Ross L, et al. Cross-resistance of clinical samples with K65R, L74V, and M184V mutations [abstract 714]. In: Program and abstracts of the 12th Conference on Retroviruses and Opportunistic Infections (Boston). Alexandria, VA: Foundation for Retrovirology and Human Health, 2005.
  • 5
    • 1542327561 scopus 로고    scopus 로고
    • Genotypic and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in antiretroviral-experienced patients
    • Miller MD, Margot N, Lu B, et al. Genotypic and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in antiretroviral-experienced patients. J Infect Dis 2004; 189:837-46.
    • (2004) J Infect Dis , vol.189 , pp. 837-846
    • Miller, M.D.1    Margot, N.2    Lu, B.3
  • 6
    • 39349105057 scopus 로고    scopus 로고
    • Prior abacavir (ABC) or didanosine (ddI) therapy with development of L74V is a risk factor for virological non-response and development of K65R in patients taking tenofovir DF (TDF)
    • McColl DJ, Bae AS, Waters JM, Margot NA, Borrota-Esoda K, Miller MD. Prior abacavir (ABC) or didanosine (ddI) therapy with development of L74V is a risk factor for virological non-response and development of K65R in patients taking tenofovir DF (TDF). Int Cong Drug Therapy HIV 2004; 7:113.
    • (2004) Int Cong Drug Therapy HIV , vol.7 , pp. 113
    • McColl, D.J.1    Bae, A.S.2    Waters, J.M.3    Margot, N.A.4    Borrota-Esoda, K.5    Miller, M.D.6
  • 7
    • 39349086934 scopus 로고    scopus 로고
    • Irlbeck D, Rouse E, Castillo S, et al. Treatment emergent mutations for previously naïve HIV-infected adults failing ZDV+3TC+EFV and ABC+3TC+EFV (CNA30024) [abstract M-112, poster 661]. In: Program and abstracts of the 11th Conference on Retroviruses and Opportunistic Infections (San Francisco). Alexandria, VA: Foundation for Retrovirology and Human Health, 2004.
    • Irlbeck D, Rouse E, Castillo S, et al. Treatment emergent mutations for previously naïve HIV-infected adults failing ZDV+3TC+EFV and ABC+3TC+EFV (CNA30024) [abstract M-112, poster 661]. In: Program and abstracts of the 11th Conference on Retroviruses and Opportunistic Infections (San Francisco). Alexandria, VA: Foundation for Retrovirology and Human Health, 2004.
  • 8
    • 1642283134 scopus 로고    scopus 로고
    • GW433908/ritonavir once daily in antiretroviral therapy-naive HIV-infected patients: Absence of protease resistance at 48 weeks
    • MacManus S, Yates PJ, Elston RC, White S, Richards N, Snowden W. GW433908/ritonavir once daily in antiretroviral therapy-naive HIV-infected patients: absence of protease resistance at 48 weeks. AIDS 2004; 18:651-5.
    • (2004) AIDS , vol.18 , pp. 651-655
    • MacManus, S.1    Yates, P.J.2    Elston, R.C.3    White, S.4    Richards, N.5    Snowden, W.6
  • 9
    • 39349108003 scopus 로고    scopus 로고
    • Parikh U, Koontz D, Sluis-Cremer N, et al. K65R: a multinucleoside resistance mutation of increasing prevalence exhibits bi-directional phenotypic antagonism with TAM [abstract 54]. In: Program and abstracts of the 11th Conference on Retroviruses and Opportunistic Infections (San Francisco). Alexandria, VA: Foundation for Retrovirology and Human Health, 2004.
    • Parikh U, Koontz D, Sluis-Cremer N, et al. K65R: a multinucleoside resistance mutation of increasing prevalence exhibits bi-directional phenotypic antagonism with TAM [abstract 54]. In: Program and abstracts of the 11th Conference on Retroviruses and Opportunistic Infections (San Francisco). Alexandria, VA: Foundation for Retrovirology and Human Health, 2004.
  • 10
    • 0037131342 scopus 로고    scopus 로고
    • The prevalence and determinants of the K65R mutation in HIV-1 reverse transcriptase in tenofovirnaive patients
    • Winston A, Mandalia S, Pillay D, et al. The prevalence and determinants of the K65R mutation in HIV-1 reverse transcriptase in tenofovirnaive patients. AIDS 2002; 16:2087-9.
    • (2002) AIDS , vol.16 , pp. 2087-2089
    • Winston, A.1    Mandalia, S.2    Pillay, D.3
  • 11
    • 2142657848 scopus 로고    scopus 로고
    • Which nucleoside and nucleotide backbone combinations select for the K65R mutation in HIV-1 reverse transcriptase
    • Winston A, Pozniak A, Mandalia S, et al. Which nucleoside and nucleotide backbone combinations select for the K65R mutation in HIV-1 reverse transcriptase. AIDS 2004; 18:949-57.
    • (2004) AIDS , vol.18 , pp. 949-957
    • Winston, A.1    Pozniak, A.2    Mandalia, S.3
  • 12
    • 23044486337 scopus 로고    scopus 로고
    • Early virologic failure in HIV-1 infected subjects on didanosine/tenofovir/efavirenz: 12-week results from a randomized trial
    • Maitland D, Moyle G, Hand J, et al. Early virologic failure in HIV-1 infected subjects on didanosine/tenofovir/efavirenz: 12-week results from a randomized trial. AIDS 2005; 19:1183-8.
    • (2005) AIDS , vol.19 , pp. 1183-1188
    • Maitland, D.1    Moyle, G.2    Hand, J.3
  • 13
    • 15744384550 scopus 로고    scopus 로고
    • Early virological failure in treatment-naïve HIV-infected adults receiving didanosine and tenofovir plus efavirenz or nevirapine
    • Leon A, Martinez E, Mallolas J, et al. Early virological failure in treatment-naïve HIV-infected adults receiving didanosine and tenofovir plus efavirenz or nevirapine. AIDS 2005; 19:213-5.
    • (2005) AIDS , vol.19 , pp. 213-215
    • Leon, A.1    Martinez, E.2    Mallolas, J.3
  • 14
    • 20044366980 scopus 로고    scopus 로고
    • Early virologic failure with a combination of tenofovir, didanosine and efavirenz
    • Podzamczer D, Ferrer E, Gatell JM, et al. Early virologic failure with a combination of tenofovir, didanosine and efavirenz. Antivir Ther 2005; 10:171-7.
    • (2005) Antivir Ther , vol.10 , pp. 171-177
    • Podzamczer, D.1    Ferrer, E.2    Gatell, J.M.3
  • 15
    • 39349098904 scopus 로고    scopus 로고
    • Farthing C, Khanlou H, Yeh V, et al. Early virological failure in a pilot study evaluating the efficacy of abacavir, lamivudine and tenofovir in the treatment naive HIV-infected patients [abstract 43]. In: Programs and abstracts of the 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment (Paris). Paris: International AIDS Society, 2003.
    • Farthing C, Khanlou H, Yeh V, et al. Early virological failure in a pilot study evaluating the efficacy of abacavir, lamivudine and tenofovir in the treatment naive HIV-infected patients [abstract 43]. In: Programs and abstracts of the 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment (Paris). Paris: International AIDS Society, 2003.
  • 16
    • 39349097622 scopus 로고    scopus 로고
    • Landman R, Peytavin G, Descamps D, et al. Low genetic barrier to resistance is a possible cause of early virologic failures in once-daily regimen of abacavir, lamivudine, and tenofovir: the Tonus Study [abstract 52]. In: Program and abstracts of the 11th Conference on Retroviruses and Opportunistic Infections (San Francisco). Alexandria, VA: Foundation for Retrovirology and Human Health, 2004.
    • Landman R, Peytavin G, Descamps D, et al. Low genetic barrier to resistance is a possible cause of early virologic failures in once-daily regimen of abacavir, lamivudine, and tenofovir: the Tonus Study [abstract 52]. In: Program and abstracts of the 11th Conference on Retroviruses and Opportunistic Infections (San Francisco). Alexandria, VA: Foundation for Retrovirology and Human Health, 2004.
  • 17
    • 39349109216 scopus 로고    scopus 로고
    • Jemsek J, Hutcherson P, Harper E, et al. Poor virologic responses and early emergence of resistance in treatment naive, HIV-infected patients receiving a once daily triple nucleoside regimen of didanosine, lamivudine, and tenofovir DF [abstract 51]. In: Program and abstracts of the 11th Conference on Retroviruses and Opportunistic Infections (San Francisco). Alexandria, VA: Foundation for Retrovirology and Human Health, 2004.
    • Jemsek J, Hutcherson P, Harper E, et al. Poor virologic responses and early emergence of resistance in treatment naive, HIV-infected patients receiving a once daily triple nucleoside regimen of didanosine, lamivudine, and tenofovir DF [abstract 51]. In: Program and abstracts of the 11th Conference on Retroviruses and Opportunistic Infections (San Francisco). Alexandria, VA: Foundation for Retrovirology and Human Health, 2004.
  • 18
    • 27944472569 scopus 로고    scopus 로고
    • Early virological non-response to tenofovir, abacavir and lamivudine in HIV-infected antiretroviral-naïve subjects
    • Gallant JE, Rodriguez AE, Weinberg W, et al. Early virological non-response to tenofovir, abacavir and lamivudine in HIV-infected antiretroviral-naïve subjects. J Infect Dis 2005; 192:1921-30.
    • (2005) J Infect Dis , vol.192 , pp. 1921-1930
    • Gallant, J.E.1    Rodriguez, A.E.2    Weinberg, W.3
  • 19
    • 39349114914 scopus 로고    scopus 로고
    • Moyle G, Nelson M, Higgs C, et al. A randomised open label comparative study of combivir + efavirenz (2 class triple therapy) versus trizivir plus tenofovor (singel class quadruple therpy) in initial therapy for HIV-1 infection [abstract H1131]. In: Program and abstracts of the 44th Interscience Conference of Antimicrobial Agents and Chemotherapy (Washington, DC). Washington, DC: American Society for Microbiology, 2004.
    • Moyle G, Nelson M, Higgs C, et al. A randomised open label comparative study of combivir + efavirenz (2 class triple therapy) versus trizivir plus tenofovor (singel class quadruple therpy) in initial therapy for HIV-1 infection [abstract H1131]. In: Program and abstracts of the 44th Interscience Conference of Antimicrobial Agents and Chemotherapy (Washington, DC). Washington, DC: American Society for Microbiology, 2004.
  • 20
    • 24044554243 scopus 로고    scopus 로고
    • Adherence to trizivir and tenofovir as a simplified salvage regimen is associated with suppression of viraemia and decreased cholesterol
    • Latham V, Stebbing J, Mandalia S, et al. Adherence to trizivir and tenofovir as a simplified salvage regimen is associated with suppression of viraemia and decreased cholesterol. J Antimicrob Chemother 2005; 56:186-9.
    • (2005) J Antimicrob Chemother , vol.56 , pp. 186-189
    • Latham, V.1    Stebbing, J.2    Mandalia, S.3
  • 21
    • 39349112655 scopus 로고    scopus 로고
    • Rodriguez AE, Hill-Zabala CE, Sloan LA, et al. Quadruple nucleoside/tide regimen of trizivir (TZV) + tenofovir (TDF) is effective following early virologic failure on an initial regimen containing a thymidine analogue + lamivudine in combination with a protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) (ESS30005, ZIP) [abstract WePE6.3c03]. In: Program and abstracts of the 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment (Rio de Janeiro). Stockholm: International AIDS Society, 2004.
    • Rodriguez AE, Hill-Zabala CE, Sloan LA, et al. Quadruple nucleoside/tide regimen of trizivir (TZV) + tenofovir (TDF) is effective following early virologic failure on an initial regimen containing a thymidine analogue + lamivudine in combination with a protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) (ESS30005, ZIP) [abstract WePE6.3c03]. In: Program and abstracts of the 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment (Rio de Janeiro). Stockholm: International AIDS Society, 2004.
  • 22
    • 39349112464 scopus 로고    scopus 로고
    • Mutuluuza CK, Walker S, Kaleebu P. Short-term virologic response (24 weeks) to a triple nucleoside/nucleotide analogue regimen in adults with HIV infection in Africa within the DART trial [abstract 22]. In: Program and abstracts of the 12th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2005.
    • Mutuluuza CK, Walker S, Kaleebu P. Short-term virologic response (24 weeks) to a triple nucleoside/nucleotide analogue regimen in adults with HIV infection in Africa within the DART trial [abstract 22]. In: Program and abstracts of the 12th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2005.
  • 23
    • 2342537759 scopus 로고    scopus 로고
    • Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection
    • Gulick RM, Ribaudo HJ, Shikuma CM, et al. Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection. N Engl J Med 2004; 350:1850-61.
    • (2004) N Engl J Med , vol.350 , pp. 1850-1861
    • Gulick, R.M.1    Ribaudo, H.J.2    Shikuma, C.M.3
  • 24
    • 39349093965 scopus 로고    scopus 로고
    • Nassar N, Armas L, Smillie J, et al. An observational cohort comparison of zidovudine-lamivudine-efavirenz to zidovudine-lamivudine-abacavir in antiretroviral-naive individuals [abstract 554]. In: Program and abstracts of the 2nd International AIDS Society Conference on HIV (Paris). Stockholm: International AIDS Society, 2003.
    • Nassar N, Armas L, Smillie J, et al. An observational cohort comparison of zidovudine-lamivudine-efavirenz to zidovudine-lamivudine-abacavir in antiretroviral-naive individuals [abstract 554]. In: Program and abstracts of the 2nd International AIDS Society Conference on HIV (Paris). Stockholm: International AIDS Society, 2003.
  • 25
    • 39349097805 scopus 로고    scopus 로고
    • Johnson M, De Wit S, Gazzard B, et al. Induction therapy with Trizivir (zidovudine/lamivudine/abacavir) [TZV] plus efavirenz [EFV]: TIME Study (AZL30004) results at 24 weeks [abstract F1/4]. In: Program and abstracts of the 9th European AIDS Conference (Warsaw, Poland). 2003.
    • Johnson M, De Wit S, Gazzard B, et al. Induction therapy with Trizivir (zidovudine/lamivudine/abacavir) [TZV] plus efavirenz [EFV]: TIME Study (AZL30004) results at 24 weeks [abstract F1/4]. In: Program and abstracts of the 9th European AIDS Conference (Warsaw, Poland). 2003.
  • 26
    • 21544442597 scopus 로고    scopus 로고
    • Induction with abacavir/lamivudine/zidovudine plus efavirenz for 48 weeks followed by 48 week maintenance with abacavir/lamivudine/zidovudine alone in antiretroviral- naïve HIV-1 infected patients
    • Markowitz M, Hill-Zabala C, Lang J, et al. Induction with abacavir/lamivudine/zidovudine plus efavirenz for 48 weeks followed by 48 week maintenance with abacavir/lamivudine/zidovudine alone in antiretroviral- naïve HIV-1 infected patients. J Acquir Immune Defic Syndr 2005; 39:257-64.
    • (2005) J Acquir Immune Defic Syndr , vol.39 , pp. 257-264
    • Markowitz, M.1    Hill-Zabala, C.2    Lang, J.3
  • 27
    • 33747646240 scopus 로고    scopus 로고
    • Study 903 Team. Resistance development of 144 weeks in treatment-naïve patients receiving tenofovir disproxil fumarate or stavudine with lamivudine and efavirenz in Study 903
    • Margot NA, Lu B, Cheng A, Miller MD; Study 903 Team. Resistance development of 144 weeks in treatment-naïve patients receiving tenofovir disproxil fumarate or stavudine with lamivudine and efavirenz in Study 903. HIV Med 2006; 7:442-50.
    • (2006) HIV Med , vol.7 , pp. 442-450
    • Margot, N.A.1    Lu, B.2    Cheng, A.3    Miller, M.D.4
  • 28
    • 19644386314 scopus 로고    scopus 로고
    • The durability of virological success of tenofovir and didanosine dosed at either 400 or 250 mg once daily
    • Tung MY, Mandalia S, Bower M, Gazzard B, Nelson M. The durability of virological success of tenofovir and didanosine dosed at either 400 or 250 mg once daily. HIV Med 2005; 6:151-4.
    • (2005) HIV Med , vol.6 , pp. 151-154
    • Tung, M.Y.1    Mandalia, S.2    Bower, M.3    Gazzard, B.4    Nelson, M.5
  • 29
    • 39349114314 scopus 로고    scopus 로고
    • Blick G, Greiger-Zanlungo P, Dupree D, Assaro J, Garton T, Arzu Z. Tenofovir DF can be safely used in combination with didanosine-EC 250mg: effects on lymphocytes, CD4, viral load and GFR [abstract TuPe2.3C22]. In: Program and abstracts of the International AIDS Society Conference on HIV Pathogenesis and Treatment. Stockholm: International AIDS Society, 2005.
    • Blick G, Greiger-Zanlungo P, Dupree D, Assaro J, Garton T, Arzu Z. Tenofovir DF can be safely used in combination with didanosine-EC 250mg: effects on lymphocytes, CD4, viral load and GFR [abstract TuPe2.3C22]. In: Program and abstracts of the International AIDS Society Conference on HIV Pathogenesis and Treatment. Stockholm: International AIDS Society, 2005.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.