Simultaneous determination of swertiamarin and its metabolites (5Z)-5-ethylidene-8-hydroxy-3,4,5,6,7,8-hexahydro-1H-pyrano[3,4-c]pyridin 1-one and erythrocentaurin in broth of Aspergillus niger by HPLC

Biomedical Chromatography

Volumn 22, Issue 2, 2008, Pages 191-195

  Chang, Jun ^a   Zhao, Xue Ming ^a   Liu, Chang Xiao ^b   Zhang, Tie Jun ^b  

^a TIANJIN UNIVERSITY   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

(5Z) 5 ethylidene 8 hydroxy 3,4,5,6,7,8 hexahydro 1H pyrano 3,4 c pyridin 1 one; Bioavailability; Caco 2 monolayer; Erythrocentaurin; Fermentation; Swertiamarin

Indexed keywords

ASPERGILLUS; BIOCHEMISTRY; BIOMOLECULES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITES; MONOLAYERS;

(5Z)-5-ETHYLIDENE-8-HYDROXY-3,4,5,6,7,8-HEXAHYDRO-1H-PYRANO [3,4-C]PYRIDIN-1-ONE; ANTI-INFLAMMATORY ACTIVITY; ASPERGILLUS NIGER; BIOAVAILABILITY; CACO-2 MONOLAYER; ERYTHROCENTAURIN; HPLC METHOD; SIMPLE++; SIMULTANEOUS DETERMINATIONS; SWERTIAMARIN;

FERMENTATION;

5 ETHYLIDENE 8 HYDROXY 3,4,5,6,7,8 HEXAHYDRO 1H PYRANO[3,4 C]PYRIDIN 1 ONE; ACETONITRILE; ASPERGILLUS NIGER EXTRACT; DRUG METABOLITE; ERYTHROCENTAURIN; FORMIC ACID; PLANT EXTRACT; SWERTIAMARIN; UNCLASSIFIED DRUG; WATER;

ACCURACY; ARTICLE; ASPERGILLUS NIGER; CALIBRATION; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DETERMINATION; ELUTION; FERMENTATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; NONHUMAN; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; TEMPERATURE;

ASPERGILLUS NIGER;

EID: 39349105271     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.913     Document Type: Article

References (13)

1. Bhattacharya SK, Reddy PK, Ghosal S, Singh AK and Sharma PV. Chemical constituents of gentianaceae XIX: CNS-depressant effects of swertiamarin. Journal of Pharmaceutical Science 1976; 65: 1547-1549.
2. Cao Y, Wang Y and Ye J. Differentiation of Swertia mussotii Franch. from artemisiae capillaris herba by capillary electrophoresis with electrochemical detection. Journal of Pharmaceutical and Biomedical Analysis. 2005; 39: 60-65.
3. Chen X, Zhang J, Xue C and Hu Z. Simultaneous determination of some active ingredients in anti-viral preparations of traditional Chinese medicine by micellar electrokinetic chromatography. Biomedical Chromatography 2004; 18: 673-680.
4. Demizu S, Ohshima Y, Hiraga Y and Takahashi K. High-performance liquid chromatographic analysis of Swertia herb. Journal of Chromatography 1986; 360: 307-311.
5. Hilgendorf C, Spahn-Langguth H and Regardh CG. Caco-2 versus Caco-2/ HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport. Journal of Pharmaceutical Sciences 2000; 89: 63-75.
6. Jiang RW, Wong KL and Chan YM. Isolation of iridoid and secoiridoid glycosides and comparative study on radix gentianae and related adulterants by HPLC analysis. Phytochemistry 2005; 66: 2674-2680.
7. Kumarasamy Y, Nahar L, Cox PJ, Jaspars M and Sarker SD. Bioactivity of secoiridoid glycosides from Centaurium erythraea. Phytomedicine 2003; 10: 344-347.
8. Li FJ, Li H, Mau CI, Chan R, Than H, Dovrak C, Yee C, Harris J and Alfredson T. Transport of levovirin prodrugs in the human intestinal caco-2 cell line. Journal of pharmaceutical sciences. 2006; 95: 1318-1325.
9. Liu HT, Wang KT and Zhao YK. Identification and determination of active components in gentiana rigescens franch by micellar electrokinetic chromatography. Journal of High Resolution Chromatography 2000; 23: 697-698.
10. Magora HB, Rahman MM, Gray AI and Cole MD. Swertiamarin from Enicostemma axillare subsp. axillare (Gentianaceae). Biochemical Systematics and Ecology 2003; 31: 553-555.
11. Yamahara J, Kobayashi M, Matsuda H and Aoki S. Anticholinergic action of Swertia japonica and an active constituent. Journal of Ethnopharmacology 1991; 33: 31-35.
12. Yang XW and Hao MY. Metabolite Analysis for Chemical Constituents of Traditional Chinese Medicines. China Medicine Press: Beijing, 2003; 317.
13. Yang H, Ding C, Duan Y and Liu J. Variation of active constituents of an important Tibet folk medicine Swertia mussotii Franch. (Gentianaceae) between artificially cultivated and naturally distributed. Journal of Ethnopharmacology 2005; 98: 31-35.