Mild and efficient synthesis of new tetraketones as lipoxygenase inhibitors and antioxidants

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 23, Issue 1, 2008, Pages 62-69

  Maharvi, Ghulam M ^a   Ali, Samar ^a   Riaz, Naheed ^a   Afza, Nighat ^a   Malik, Abdul ^b   Ashraf, Muhammad ^c   Iqbal, Lubna ^a   Lateef, Mehreen ^a  

^a PAKISTAN COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH   (Pakistan)

^b UNIVERSITY OF KARACHI   (Pakistan)

^c THE ISLAMIA UNIVERSITY OF BAHAWALPUR   (Pakistan)

Author keywords

Antioxidant; Inhibitory activity; Lipoxygenase; Tetraketones

Indexed keywords

2 CHLOROPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 2 HYDROXYPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 2 METHOXYPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 2 NITROPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 3 BROMO 4 HYDROXYPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 3 BROMOPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 3 CHLOROPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 3 HYDROXYPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 3 NITROPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 3,4 DIMETHOXYPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 4 ETHOXYPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 4 HYDROXYPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 4 METHOXYPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 4 METHYLPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 4 N,N DIMETHYLAMINOPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 4 NITROPHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 5 METHYLFURANYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); 5,5 DIMETHYL 1,3 CYCLOHEXANEDIONE; ALPHA BROMOSTYRENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); ANTIOXIDANT; BAICALEIN; BUTYLATED HYDROXYANISOLE; FURANYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); KETONE DERIVATIVE; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; PHENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); STYRENYL 2,2' METHYLENEBIS(5,5 DIMETHYLCYCLOHEXANE 1,3 DIONE); TETRAKETONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; POLYMERIZATION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTIOXIDANTS; FREE RADICAL SCAVENGERS; KETONES; LIPOXYGENASE INHIBITORS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 39349094355     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360701408754     Document Type: Article

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