Immunomodulatory effects of Astragalus polysaccharide in diabetic mice

Journal of Chinese Integrative Medicine

Volumn 6, Issue 2, 2008, Pages 166-170

  Li, Ru Jiang ^a   Qiu, Shu Dong ^a   Chen, Hong Xia ^b   Wang, Li Rong ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Astragalus; Diabetes mellitus; Immunomodulators; Mice; Type 1

Indexed keywords

ASTRAGALUS EXTRACT; CONCANAVALIN A; GAMMA INTERFERON; INSULIN ANTIBODY; INTERLEUKIN 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYSACCHARIDE; SODIUM CHLORIDE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CHINESE HERB; DOSE RESPONSE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; HUMORAL IMMUNITY; IMMUNOMODULATION; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SENSITIVITY; LOW DRUG DOSE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RECEPTOR UPREGULATION; SPLEEN CELL; WESTERN BLOTTING;

ANIMALS; ASTRAGALUS MEMBRANACEUS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; IMMUNOLOGIC FACTORS; INTERFERON-GAMMA; INTERLEUKIN-4; MALE; MICE; MICE, INBRED C57BL; POLYSACCHARIDES; PPAR GAMMA;

EID: 39149145870     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20080212     Document Type: Article

References (7)

1. Roep BO. The role of T-cells in the pathogenesis of type 1 diabetes: from cause to cure. Diabetologia. 2003; 46 (3): 305-321.
2. Silveira PA, Grey ST. B cells in the spotlight: innocent bystanders or major players in the pathogenesis of type 1 diabetes. Trends Endocrinol Metab. 2006; 17(4): 128-135.
3. Lipsett M, Aikin R, Hanley S, et al. Islet neogenesis: a potential therapeutic tool in type 1 diabetes. Int J Biochem Cell Biol. 2006; 38(4): 498-503.
4. Su L, Mao JC, Gu JH. Effect of intravenous drip infusion of cyclophosphamide with high-dose Astragalus injection in treating lupus nephritis. Zhong Xi Yi Jie He Xue Bao. 2007; 5(3): 272-275.
5. Chen W, Liu F, Yu MH, et al. Astragalus polysaccharide prevent type 1 diabetes in nonobese diabetic mice. Fu Dan Xue Bao (Yi Xue Ke Xue Ban). 2001; 28(1): 57-60.
6. Weng L, Liu Y, Liu XY, et al. Effect of Astragalus polysaccharide on splenocyte cytokine secretion patterns and NK cells. Zhong Yi Yao Xue Kan. 2003; 21(9): 1522-1524.
7. Gor DO. Rose NR, Greenspan NS. TH1-TH2: a procrustean paradigm. Nat Immunol. 2003; 4(6): 503-505.