Pharmacokinetics and pharmacodynamics of indomethacin: Effects on cerebral blood flow in anaesthetized sheep

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 3, 2008, Pages 317-323

  Upton, Richard N ^a,b   Rasmussen, Mads ^b,c   Grant, Cliff ^b   Martinez, Allison M ^b   Cold, Georg E ^c   Ludbrook, Guy L ^b  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Brain; Indirect response model; Indomethacin; Isoflurane; Pharmacodynamics; Pharmacokinetics; Propofol

Indexed keywords

INDOMETACIN; ISOFLURANE; PROPOFOL;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD; BLOOD BRAIN BARRIER; BLOOD LEVEL; BLOOD VESSEL TONE; BRAIN BLOOD FLOW; CONTROLLED STUDY; DIFFUSION; DRUG EFFICACY; DRUG UPTAKE; ENDOTHELIUM; FEMALE; INTRACRANIAL PRESSURE; KINETICS; MODEL; NONHUMAN; NONLINEAR SYSTEM; PHARMACODYNAMICS; PHARMACOKINETICS; SHEEP; VASOCONSTRICTION;

ANESTHESIA, INHALATION; ANESTHETICS, INHALATION; ANESTHETICS, INTRAVENOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD FLOW VELOCITY; CEREBRAL CORTEX; DRUG INTERACTIONS; INDOMETHACIN; ISOFLURANE; PROPOFOL; SHEEP;

EID: 39149138140     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04818.x     Document Type: Article

References (21)

1. Bundgaard H, Jensen K, Cold GE, Bergholt B, Frederiksen R, Pless S. Effects of perioperative indomethacin on intracranial pressure, cerebral blood flow, and cerebral metabolism in patients subjected to craniotomy for cerebral tumors. J. Neurosurg. Anesthesiol. 1996 8 : 273 9.
2. Jensen K, Ohrstrom J, Cold GE, Astrup J. The effects of indomethacin on intracranial pressure, cerebral blood flow and cerebral metabolism in patients with severe head injury and intracranial hypertension. Acta Neurochir. 1991 108 : 116 21.
3. Rasmussen M, Upton RN, Grant C, Martinez AM, Cold GE, Ludbrook G. The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension. Anesth. Analg. 2006 102 : 1823 9.
4. Upton R, Grant C, Ludbrook G. An ultrasonic Doppler venous outflow method for the continuous measurement of cerebral blood flow in conscious sheep. J. Cereb. Blood Flow Metab. 1994 14 : 680 8.
5. Doolette DJ, Upton RN, Grant C. Agreement between ultrasonic Doppler venous outflow and Kety and Schmidt estimates of cerebral blood flow. Clin. Exp. Pharmacol. Physiol. 1999 26 : 736 40.
6. Vinagre E, Encinas T, Ballesteros C et al. Pharmacokinetics of indomethacin after intraruminal administration to sheep. Zentralbl. Veterinarmed. A 1999 46 : 361 6.
7. Foster DJ, Upton RN, Somogyi AA, Grant C, Martinez A. The acute disposition of (r)- and (s)-methadone in brain and lung of sheep. J. Pharmacokinet. Pharmacodyn. 2005 32 : 547 70.
8. Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J. Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin. Pharmacol. Ther. 1979 25 : 358 71.
9. Gabrielsson J, Jusko WJ, Alari L. Modeling of dose-response-time data: Four examples of estimating the turnover parameters and generating kinetic functions from response profiles. Biopharm. Drug Dispos. 2000 21 : 41 52.
10. R Development Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna. 2005.
11. Clark DE. In silico prediction of blood-brain barrier permeation. Drug Discov. Today 2003 8 : 927 33.
12. Helleberg L. Clinical pharmacokinetics of indomethacin. Clin. Pharmacokinet. 1981 6 : 245 58.
13. Parepally JM, Mandula H, Smith QR. Brain uptake of nonsteroidal anti-inflammatory drugs: Ibuprofen, flurbiprofen, and indomethacin. Pharm. Res. 2006 23 : 873 81.
14. Bachmeier CJ, Trickler WJ, Miller DW. Comparison of drug efflux transport kinetics in various blood-brain barrier models. Drug Metab. Dispos. 2006 34 : 998 1003.
15. McGeer PL, McGeer EG. NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies. Neurobiol. Aging 2006 28 : 639 47.
16. Bannwarth B, Netter P, Pourel J, Royer RJ, Gaucher A. Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs in the cerebrospinal fluid. Biomed. Pharmacother. 1989 43 : 121 6.
17. Faraci FM, Heistad DD. Regulation of the cerebral circulation: Role of endothelium and potassium channels. Physiol. Rev. 1998 78 : 53 97.
18. Rasmussen M. Treatment of elevated intracranial pressure with indomethacin: Friend or foe? Acta Anaesthesiol. Scand. 2005 49 : 341 50.
19. Harrigan MR, Tuteja S, Neudeck BL. Indomethacin in the management of elevated intracranial pressure: A review. J. Neurotrauma 1997 14 : 637 50.
20. Parfenova H, Hsu P, Leffler CW. Dilator prostanoid-induced cyclic AMP formation and release by cerebral microvascular smooth muscle cells: Inhibition by indomethacin. J. Pharmacol. Exp. Ther. 1995 272 : 44 52.
21. Parfenova H, Zuckerman S, Leffler CW. Inhibitory effect of indomethacin on prostacyclin receptor-mediated cerebral vascular responses. Am. J. Physiol. 1995 268 : H1884 90.