Knockdown of the L3/Lhx8 gene suppresses cholinergic differentiation of murine embryonic stem cell-derived spheres

International Journal of Developmental Neuroscience

Volumn 26, Issue 2, 2008, Pages 249-252

  Manabe, Takayuki ^a   Tatsumi, Kouko ^a   Inoue, Masahide ^a   Matsuyoshi, Hiroko ^a   Makinodan, Manabu ^a   Yamauchi, Takahira ^a   Makinodan, Eri ^a   Yokoyama, Shohei ^a   Sakumura, Ryoko ^a   Okuda, Hiroaki ^a   Wanaka, Akio ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Acetylcholine; Basal forebrain; GABA; L3 Lhx8; Lim homeobox; RNAi

Indexed keywords

4 AMINOBUTYRIC ACID; PROTEIN; PROTEIN TUJ1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CHOLINERGIC SYSTEM; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; FOREBRAIN; GENE; GENE EXPRESSION; IN VITRO STUDY; L3 LHX8 GENE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ACETYLCHOLINE; ANIMALS; BASAL NUCLEUS OF MEYNERT; CELL DIFFERENTIATION; CELL LINE; CHOLINE O-ACETYLTRANSFERASE; CHOLINERGIC FIBERS; CLONE CELLS; DOWN-REGULATION; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLIAL FIBRILLARY ACIDIC PROTEIN; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; MICE; NEURONS; PHENOTYPE; RNA, SMALL INTERFERING; SPHEROIDS, CELLULAR; TUBULIN;

MURINAE; MUS;

EID: 39149120579     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2007.11.004     Document Type: Article

References (9)

1. Bachy I., and Rétaux S. GABAergic specification in the basal forebrain is controlled by the LIM-hd factor Lhx7. Dev. Biol. 291 (2006) 218-226
2. Manabe T., Katayama T., Sato N., Gomi F., Hitomi J., Yanagita T., Kudo T., Honda A., Mori Y., Matsuzaki S., Imaizumi K., Mayeda A., and Tohyama M. Induced HMGA1a expression causes aberrant splicing of presenilin-2 pre-mRNA in sporadic Alzheimer's disease. Cell Death Differ. 10 (2003) 698-708
3. Manabe T., Tatsumi K., Inoue M., Matsuyoshi H., Makinodan M., Yokoyama S., and Wanaka A. L3/Lhx8 is involved in the determination of cholinergic or GABAergic cell fate. J. Neurochem. 94 (2005) 723-730
4. Manabe T., Tatsumi K., Inoue M., Makinodan M., Yamauchi T., Makinodan E., Yokoyama S., Sakumura R., and Wanaka A. L3/Lhx8 is a pivotal factor for cholinergic differentiation of murine embryonic stem cells. Cell Death Differ. 14 (2007) 1080-1085
5. Matsumoto K., Tanaka T., Furuyama T., Kashihara Y., Mori T., Ishii N., Kitanaka J., Takemura M., Tohyama M., and Wanaka A. L3, a novel murine LIM-homeodomain transcription factor expressed in the ventral telencephalon and the mesenchyme surrounding the oral cavity. Neurosci. Lett. 204 (1996) 113-116
6. Mori T., Yuxing Z., Takaki H., Takeuchi M., Iseki K., Hagino S., Kitanaka J., Takemura M., Misawa H., Ikawa M., Okabe M., and Wanaka A. The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons. Eur. J. Neurosci. 19 (2004) 3129-3141
7. Otero J.J., Fu W., Kan L., Cuadra A.E., and Kessler J.A. Beta-catenin signaling is required for neural differentiation of embryonic stem cells. Development 131 (2004) 3545-3557
8. Whitehouse P.J., Price D.L., Clark A.W., Coyle J.T., and DeLong M.R. Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann. Neurol. 10 (1981) 122-126
9. Whitehouse P.J., Price D.L., Struble R.G., Clark A.W., Coyle J.T., and Delon M.R. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215 (1982) 1237-1239