A pneumococcal MerR-like regulator and S-nitrosoglutathione reductase are required for systemic virulence

Journal of Infectious Diseases

Volumn 196, Issue 12, 2007, Pages 1820-1826

  Stroeher, Uwe H ^a   Kidd, Stephen P ^b   Stafford, Sian L ^b   Jennings, Michael P ^b   Paton, James C ^a   McEwan, Alastair G ^b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; BACTERIAL PROTEIN; CYSTEINE; MERR PROTEIN; NITRIC OXIDE; OXIDOREDUCTASE; PROTEIN NM1R; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; S NITROSOGLUTATHIONE; UNCLASSIFIED DRUG; ALDEHYDE DEHYDROGENASE; DNA BINDING PROTEIN; FORMALDEHYDE DEHYDROGENASE (GLUTATHIONE); FORMALDEHYDE DEHYDROGENASE, GLUTATHIONE INDEPENDENT; FORMALDEHYDE DEHYDROGENASE, GLUTATHIONE-INDEPENDENT; MERR PROTEIN, BACTERIA; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL CELL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; ANIMAL; BIOSYNTHESIS; CELL LINE; CHEMISTRY; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; MOUSE; NASOPHARYNX; NEISSERIA GONORRHOEAE; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PHYLOGENY; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; TUMOR CELL LINE; VIRULENCE;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; BACTERIAL PROTEINS; BASE SEQUENCE; CELL LINE; CELL LINE, TUMOR; DNA-BINDING PROTEINS; FEMALE; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NAD; NASOPHARYNX; NEISSERIA GONORRHOEAE; NITRIC OXIDE; PHYLOGENY; RESPIRATORY MUCOSA; STREPTOCOCCUS PNEUMONIAE; TRANSCRIPTION, GENETIC; VIRULENCE;

EID: 39149119282     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/523107     Document Type: Article

References (20)

1. Bogdan C, Rollinghoff M, Diefenbach A. Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity. Curr Opin Immunol 2000; 12:64-76.
2. Marriott HM, Ali F, Read RC, Mitchell TJ, Whyte MKB, Dockrell DH. Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection. FASEB J 2004; 18:1126-8.
3. Kerr AR, Wei XQ, Andrew PW, Mitchell TJ. Nitric oxide exerts distinct effects in local and systemic infections with Streptococcus pneumoniae. Microb Pathog 2004; 36:303-10.
4. Bang I-S, Liu L, Vazquez-Torres A, Crouch M-L, Stamler JS, Fang FC. Maintenance of nitric oxide and redox homeostasis by the Salmonella flavohemoglobin Hmp. J Biol Chem 2006; 281:28039-47.
5. Pacelli R, Wink DA, Cook JA, et al. Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli. J Exp Med 1995; 182:1469-79.
6. Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature 2001; 410:490-4.
7. Avery OT, MacLeod CM, McCarty M. Studies on the chemical nature of the substance inducing transformation of pneumococcal types: induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III. J Exp Med 1944; 79:137-58.
8. Berry AM, Yother J, Briles DE, Hansman D, Paton JC. Reduced virulence of a defined pneumolysin negative mutant of Streptococcus pneumoniae. Infect Immun 1989; 57:2037-42.
9. Yother J, McDaniel LS, Briles DE. Transformation of encapsulated Streptococcus pneumoniae. J Bacteriol 1986; 168:1463-5.
10. Morona JK, Paton JC, Miller DC, Morona R. Tyrosine phosphorylation of CpsD negatively regulates capsular polysaccharide biosynthesis in Streptococcus pneumoniae. Mol Microbiol 2000; 35:1431-42.
11. Macrina FL, Evans RP, Tobian JA, Hartley DL, Clewell DB, Jones KR. Novel shuttle plasmid vehicles for Escherichia-Streptococcus transgeneric cloning. Gene 1983; 25:145-50.
12. Thompson JD, Higgins DG, Gibson TJ. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 1994; 22:4673-80.
13. Felsenstein J. PHYLIP - phylogeny interence package (version 3.2). Cladistics 1989; 5:164-6.
14. Ogunniyi AD, Giammarino P, Paton JC. The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo. Microbiology 2002; 148: 2045-53.
15. -ΔΔCT method. Methods 2001; 25: 402-8.
16. Kidd SP, Potter AJ, Apicella MA, Jennings MP, McEwan AG. NmlR of Neisseria gonorrhoeae: a novel transcription factor from the MerR family. Mol Microbiol 2005; 57:1676-89.
17. Stroeher UH, Paton AW, Ogunniyi AD, Paton JC. Mutation of luxS of Streptococcus pneumoniae affects virulence in a mouse model. Infect Immun 2003; 71:3206-12.
18. Wu HY, Virolainen A, Mathews B, King J, Russell MW, Briles DE. Establishment of a Streptococcus pneumoniae nasopharyngeal colonization model in adult mice. Microb Pathog 1997; 23:127-37.
19. Talbot UM, Paton AW, Paton JC. Uptake of Streptococcus pneumoniae by respiratory epithelial cells. Infect Immun 1996; 64:3772-7.
20. Brown NL, Stoyanov JV, Kidd SP, Hobman JL. The MerR family of transcriptional regulators. FEMS Microbiol Rev 2003; 27:145-63.