Long-term tolerance to allogeneic thymus transplants in complete DiGeorge anomaly

Clinical Immunology

Volumn 126, Issue 3, 2008, Pages 277-281

  Chinn, Ivan K ^a   Devlin, Blythe H ^a   Li, Yi Ju ^a   Markert, M Louise ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Allorecognition; DiGeorge anomaly; Thymus transplantation; Tolerance

Indexed keywords

PHYTOHEMAGGLUTININ;

ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; DIGEORGE SYNDROME; FEMALE; HLA MATCHING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IN VITRO STUDY; INFANT; MALE; MIXED LYMPHOCYTE CULTURE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS GRAFT; TRANSPLANTATION TOLERANCE;

DIGEORGE SYNDROME; FEMALE; HUMANS; INFANT; MALE; THYMUS GLAND; TIME FACTORS; TISSUE DONORS; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 39149115649     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2007.11.009     Document Type: Article

References (14)

1. Thomas R.A., Landing B.H., and Wells T.R. Embryologic and other developmental considerations of thirty-eight possible variants of the DiGeorge anomaly (DGA). Am. J. Med. Genet., Suppl. 3 (1987) 43-66
2. DiGeorge A.M. Discussion of Cooper MD, Peterson RDA, Good RA. A new concept of cellular basis of immunity. J. Pediatr. 67 (1965) 907
3. Conley M.E., Beckwith J.B., Mancer J.F.K., and Tenckhoff L. The spectrum of the DiGeorge syndrome. J. Pediatr. 94 (1979) 883-890
4. Müller W., Peter H.H., Wilken M., Juppner H., Kallfelz H.C., Krohn H.P., Miller K., and Rieger C.H. The DiGeorge syndrome: I. Clinical evaluation and course of partial and complete forms of the syndrome. Eur. J. Pediatr. 147 (1988) 496-502
5. Hong R. The DiGeorge anomaly. Immunodefic. Rev. 3 (1991) 1-14
6. Markert M.L., Hummell D.S., Rosenblatt H.M., Schiff S.E., Harville T.O., Williams L.W., Schiff R.I., and Buckley R.H. Complete DiGeorge syndrome: persistence of profound immunodeficiency. J. Pediatr. 132 (1998) 15-21
7. Markert M.L., Boeck A., Hale L.P., Kloster A.L., McLaughlin T.M., Batchvarova M.N., Douek D.C., Koup R.A., Kostyu D.D., Ward F.E., Rice H.E., Mahaffey S.M., Schiff S.E., Buckley R.H., and Haynes B.F. Thymus transplantation in complete DiGeorge syndrome. N. Engl. J. Med. 341 (1999) 1180-1189
8. Markert M.L., Devlin B.H., Alexieff M.J., Li J., McCarthy E.A., Gupton S.E., Chinn I.K., Hale L.P., Kepler T.B., He M., Sarzotti M., Skinner M.A., Rice H.E., and Hoehner J.C. Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants. Blood 109 (2007) 4539-4547
9. Sherman L.A., and Chattopadhyay S. The molecular basis of allorecognition. Annu. Rev. Immunol. 11 (1993) 385-402
10. Markert M.L., Sarzotti M., Ozaki D.A., Sempowski G.D., Rhein M.E., Hale L.P., Le Deist F., Alexieff M.J., Li J., Hauser E.R., Haynes B.F., Rice H.E., Skinner M.A., Mahaffey S.M., Jaggers J., Stein L.D., and Mill M.R. Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients. Blood 102 (2003) 1121-1130
11. Markert M.L., Alexieff M.J., Li J., Sarzotti M., Ozaki D.A., Devlin B.H., Sedlak D.A., Sempowski G.D., Hale L.P., Rice H.E., Mahaffey S.M., and Skinner M.A. Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome. Blood 104 (2004) 2574-2581
12. Markert M.L., Alexieff M.J., Li J., Sarzotti M., Ozaki D.A., Devlin B.H., Sempowski G.D., Rhein M.E., Szabolcs P., Hale L.P., Buckley R.H., Coyne K.E., Rice H.E., Mahaffey S.M., and Skinner M.A. Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases. J. Allergy Clin. Immunol. 113 (2004) 734-741
13. Kindred B., and Sordat B. Lymphocytes which differentiate in an allogeneic thymus: II. Evidence for both central and peripheral mechanisms in tolerance to donor strain tissues. Eur. J. Immunol. 7 (1977) 437-442
14. Hong R. Transplantation of cultured thymus fragments. III. Induction of allotolerance. Thymus 4 (1982) 91-106