The endocannabinoid system as a novel target for the treatment of liver fibrosis;Le système endocannabinoïde, une nouvelle cible pour le traitement de la fibrose hépatique

Pathologie Biologie

Volumn 56, Issue 1, 2008, Pages 36-38

  Teixeira Clerc, F ^a,b   Julien, B ^a,b   Grenard, P ^a,b   Tran Van Nhieu, J ^a,b,c   Deveaux, V ^a,b   Hezode, C ^a,b,c   Mallat, A ^a,b,c   Lotersztajn, S ^a,b,c  

^a INSERM U955   (France)

^b FACULTÉ DE MÉDECINE   (France)

^c HENRI MONDOR HOSPITAL   (France)

Author keywords

Cannabis; CB1 receptor; CB2 receptor; Endocannabinoids; Fibrosis; Liver

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; ENDOCANNABINOID; RIMONABANT;

ARTICLE; CANNABIS SMOKING; DISEASE COURSE; DRUG EFFECT; FIBROGENESIS; HEPATITIS C; HUMAN; LIVER FIBROSIS; NONHUMAN; RISK FACTOR;

ANIMALS; CANNABIS; ENDOCANNABINOIDS; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RISK FACTORS;

EID: 39149111573     PISSN: 03698114     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.patbio.2007.01.001     Document Type: Article

References (5)

1. Mallat A., and Lotersztajn S. Endocannabinoids as novel mediators of liver diseases. J. Endocrinol. Invest. 29 (2006) 58-65
2. Teixeira-Clerc F., Julien B., Grenard P., Tran-Van-Nhieu J., Deveaux V., Liying L., et al. CB1 cannabinoid receptor antagonism: a novel strategy for the treatment of liver fibrosis. Nat. Med. 12 (2006) 671-676
3. Hezode C., Roudot-Thoraval F., Nguyen S., Grenard P., Julien B., Zafrani E.S., et al. Daily cannabis smoking as a risk factor for fibrosis progression in chronic hepatitis C. Hepatology 42 (2005) 63-71
4. Julien B., Grenard P., Teixeira-Clerc F., Tran-Van-Nhieu J., Li L., Karzak M., et al. Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology 128 (2005) 742-755
5. Lotersztajn S., Julien B., Teixeira-Clerc F., Grenard P., and Mallat A. Hepatic fibrosis: molecular mechanisms and drug targets. Annu. Rev. Pharmacol. Toxicol. 45 (2005) 605-628