Synthesis of anhydride precursors of the environment-sensitive fluorophores 4-dmap and 6-dmn

Nature Protocols

Volumn 2, Issue 12, 2007, Pages 3219-3225

  Sainlos, Matthieu ^a   Imperiali, Barbara ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; 4 DIMETHYLAMINOPYRIDINE; 4-DIMETHYLAMINOPYRIDINE; 6 N,N DIMETHYLAMINO 2,3 NAPHTHALIMIDE; 6-N,N-DIMETHYLAMINO-2,3-NAPHTHALIMIDE; DRUG DERIVATIVE; FLUORESCENT DYE; IMIDE; NAPHTHALENE DERIVATIVE; NAPHTHALIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

4-AMINOPYRIDINE; FLUORESCENT DYES; IMIDES; MOLECULAR STRUCTURE; NAPHTHALENES; NAPHTHALIMIDES;

EID: 39149104346     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2007.444     Document Type: Article

References (6)

1. Valeur, B. MotecutarFtuorescence: Pnnciptes andApptications (Wiley-VCH, Weinheim, Germany, 2002).
2. Lakowicz, J.R. Pnnciptes of Fluorescence Spectroscopy (Springer, New York, 2006).
3. Vazquez, M.E., Blanco, J.B. & Imperiali, B. Photophysics and biological applications of the environment-sensitive fluorophore 6-N, N-dimethylamino-2,3- naphthalimide. J. Am. Chem. Soc. 127,1300-1306 (2005).
4. Vazquez, M.E., Rothman, D.M. & Imperiali, B. A new environment-sensitive fluorescentamino acid for Fmoc-based solid phase peptide synthesis. Org. Biomot. Chem. 2, 1965-1966 (2004).
5. Sainlos, M. & Imperiali, B. Tools for investigating peptide-protein interactions: peptide incorporation of environment-sensitive fluorophores via on-resin derivatization. Nat Protoc. 2, 3201-3209 (2007).
6. Sainlos, M. & Imperiali, B. Tools for investigating peptide-protein interactions: peptide incorporation of environment-sensitive fluorophores through SPPS-based 'building block' approach. Nat. Protoc. 2, 3210-3218 (2007).