Protein kinase A and mitogen-activated protein kinase pathways mediate cAMP induction of α-epithelial Na+ channels (α-ENaC)

Journal of Cellular Physiology

Volumn 215, Issue 1, 2008, Pages 101-110

  Mustafa, Shamimunisa B ^a   Castro, Robert ^a   Falck, Alison J ^a   Petershack, Jean A ^a   Henson, Barbara M ^a   Mendoza, Yvonne M ^a   Choudary, Ahsan ^a   Seidner, Steven R ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA EPITHELIAL SODIUM CHANNEL; BUCLADESINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EPITHELIAL SODIUM CHANNEL; KT 5720; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; UNCLASSIFIED DRUG; MESSENGER RNA; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STRAIN SMG C6; DRUG MECHANISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SODIUM TRANSPORT; ANIMAL; CHANNEL GATING; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; RNA STABILITY;

RATTUS;

ANIMALS; BUCLADESINE; CELL LINE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; EPITHELIAL CELLS; EPITHELIAL SODIUM CHANNEL; GENE EXPRESSION REGULATION; HUMANS; ION CHANNEL GATING; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; RNA STABILITY; RNA, MESSENGER;

EID: 39149104082     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21291     Document Type: Article

References (48)

1. Ahn S, Olive M, Aggarwal S, Krylov D, Ginty DD, Vinson C. 1998. A dominant‐negative inhibitor of CREB reveals that it is a general mediator of stimulus‐dependent transcription of c‐fos. Mol Cell Biol 18: 967–977.
2. Barbry P, Hofman P. 1997. Molecular biology of Na + absorption. Am J Physiol 273: G571–G585.
3. Benos DJ, Awayda MS, Ismailov II, Johnson JP. 1995. Structure and function of amiloride‐sensitive Na + channels. J Membr Biol 143: 1–18.
4. Berthiaume Y, Folkesson HG, Matthay MA. 2002. Lung edema clearance: 20 years of progress: Invited review: Alveolar edema fluid clearance in the injured lung. J Appl Physiol 93: 2207–2213.
5. Bland RD, Nielson DW. 1992. Developmental changes in lung epithelial ion transport and liquid movement. Annu Rev Physiol 54: 373–394.
6. Busca R, Abbe P, Mantoux F, Aberdam E, Peyssonnaux C, Eychene A, Ortonne JP, Ballotti R. 2000. Ras mediates the cAMP‐dependent activation of extracellular signal‐regulated kinases (ERKs) in melanocytes. EMBO J 19: 2900–2910.
7. Canessa CM, Horisberger JD, Rossier BC. 1993. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature 361: 467–470.
8. Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, Horisberger JD, Rossier BC. 1994. Amiloride‐sensitive epithelial Na + channel is made of three homologous subunits. Nature 367: 463–467.
9. Castro R, Barlow‐Walden L, Woodson T, Kerecman JD, Zhang GH, Martinez JR. 2000. Ion transport in an immortalized rat submandibular cell line SMG‐ C6. Proc Soc Exp Biol Med 225: 39–48.
10. Chen XJ, Eaton DC, Jain L. 2002. Beta‐adrenergic regulation of amiloride‐sensitive lung sodium channels. Am J Physiol 282: L609–L620.
11. Dagenais A, Kothary R, Berthiaume Y. 1997. The alpha subunit of the epithelial sodium channel in the mouse: Developmental regulation of its expression. Pediatr Res 42: 327–334.
12. Dagenais A, Denis C, Vives MF, Girouard S, Masse C, Nguyen T, Yamagata T, Grygorczyk C, Kothary R, Berthiaume Y. 2001. Modulation of alpha‐ENaC and alpha1‐Na + ‐K + ‐ATPase by cAMP and dexamethasone in alveolar epithelial cells. Am J Physiol 281: L217–L230.
13. Dagenais A, Frechette R, Yamagata Y, Yamagata T, Carmel J‐F, Clermont M‐E, Brochiero E, Masse C, Berthiaume Y. 2003. Downregulation of ENaC activity and expression by TNF‐α in alveolar epithelial cells. Am J Physiol 286: L301–L311.
14. Davis RJ. 1994. MAPKs: New JNK expands the group. Trends Biochem Sci 19: 470–473.
15. Du K, Montminy M. 1998. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem 273: 32377–32379.
16. Finley N, Norlin A, Baines DL, Folkesson HG. 1998. Alveolar epithelial fluid clearance is mediated by endogenous catecholamines at birth in guinea pigs. J Clin Invest 101: 972–981.
17. Garty H, Palmer LG. 1997. Epithelial sodium channels: Function, structure, and regulation. Physiol Rev 77: 359–396.
18. Giallard DJ, Hinnrasky S, Coscoy P, Hofman P, Matthay MA, Puchelle E, Barbry P. 2000. Early expression of β‐ and γ‐subunits of epithelial sodium channel during human airway development. Am J Physiol 278: L177–L484.
19. Gonzalez GA, Montminy MR. 1989. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59: 675–680.
20. Habener JF, Miller CP, Vallejo M. 1995. cAMP‐dependent regulation of gene transcription by cAMP response element‐binding protein and cAMP response element modulator. Vitam Horm 51: 1–57.
21. Hansen TO, Rehfeld JF, Nielsen FC. 1999. Mitogen‐activated protein kinase and protein kinase a signaling pathways stimulate cholecystokinin transcription via activation of cyclic adenosine 3′,5′‐monophosphate response element‐binding protein. Mol Endocrinol 13: 466–475.
22. Hummler E, Barker P, Gatzy J, Beermann F, Verdumo C, Schmidt A, Boucher R, Rossier BC. 1996. Early death due to defective neonatal lung liquid clearance in alpha‐ENaC‐deficient mice. Nat Genet 12: 325–328.
23. Impey S, Obrietan K, Wong ST, Poser S, Yano S, Wayman G, Deloulme JC, Chan G, Storm DR. 1998. Cross talk between ERK and PKA is required for Ca 2+ stimulation of CREB‐dependent transcription and ERK nuclear translocation. Neuron 21: 869–883.
24. Jain L, Chen X, Malik B, Al‐Khalili O, Eaton DC. 1999. Antisense oligonucleotides against the a‐subunit of ENaC decrease lung epithelial cation‐channel activity. Am J Physiol 276: L1046–1051.
25. Kwok RP, Lundblad JR, Chrivia JC, Richards JP, Bachinger HP, Brennan RG, Roberts SG, Green MR, Goodman RH. 1994. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370: 223–226.
26. Liebmann C. 2001. Regulation of MAP kinase activity by peptide receptor signaling pathway: Paradigms of multiplicity. Cell Signal 13: 777–785.
27. Maizels ET, Cottom J, Jones JC, Hunzicker‐Dunn M. 1998. Follicle stimulating hormone (FSH) activates the p38 mitogen‐activated protein kinase pathway, inducing small heat shock protein phosphorylation and cell rounding in immature rat ovarian granulosa cells. Endocrinology 139: 3353–3356.
28. Matthay MA, Folkesson HG, Verkman AS. 1996. Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am J Physiol 270: L487–L503.
29. Matthay MA, Clerici C, Saumon G. 2002. Invited review: Active fluid clearance from the distal air spaces of the lung. J App Physiol 93: 1533–1541.
30. McGraw DW, Fukuda N, James PF, Forbes SL, Woo AL, Lingrel JB, Witte DP, Matthay MA, Liggett SB. 2001. Targeted transgenic expression of beta(2)‐adrenergic receptors to type II cells increases alveolar fluid clearance. Am J Physiol 281: L895–L903.
31. Morris RG, Schafer JA. 2002. cAMP increases density of ENaC subunits in the apical membrane of MDCK cells in direct proportion to amiloride‐sensitive Na(+) transport. J Gen Physiol 120: 71–85.
32. O'Brodovich H. 1991. Epithelial ion transport in the fetal and perinatal lung. Am J Physiol 261: C555–C564.
33. Otulakowski G, Rafii B, Bremner HR, O'Brodovich H. 1999. Structure and hormone responsiveness of the gene encoding the alpha‐subunit of the rat amiloride‐sensitive epithelial sodium channel. Am J Respir Cell Mol Biol 20: 1028–1040.
34. Planes C, Blot‐Chabaud M, Matthay MA, Couette S, Uchida T, Clerici C. 2002. Hypoxia and b2‐agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. J Biol Chem 277: 47318–47324.
35. Quissell DO, Barzen KA, Gruenert DC, Redman RS, Camden JM, Turner JT. 1997. Development and characterization of SV40 immortalized rat submandibular acinar cell lines. In Vitro Cell Dev Biol 33: 164–173.
36. Richards JS. 2001. New signaling pathways for hormones and cyclic adenosine 3',5'‐monophosphate action in endocrine cells. Mol Endocrinol 15: 209–218.
37. Saldias FJ, Lecuona E, Comellas AP, Ridge KM, Rutschman DH, Sznajder JI. 2000. Beta‐adrenergic stimulation restores rat lung ability to clear edema in ventilator‐associated lung injury. Am J Resp Crit Care Med 162: 282–287.
38. Sartori C, Fang X, McGraw DW, Koch P, Snider ME, Folkesson HG, Matthay MA, Sartori C, Fang X, McGraw DW, Koch P, Snider ME, Folkesson HG, Matthay MA. 2002. Selected contribution: Long‐term effects of beta(2)‐adrenergic receptor stimulation on alveolar fluid clearance in mice. J Appl Physiol 93: 1875–1880.
39. Schaeffer HJ, Weber MJ. 1999. Mitogen‐activated protein kinases: Specific messages from ubiquitous messengers. Mol Cell Biol 19: 2435–2444.
40. Schwartz JH. 2001. The many dimensions of cAMP signaling. Proc Natl Acad Sci USA 98: 13482–13484.
41. Snyder PM. 2000. Liddle's syndrome mutations disrupt cAMP‐mediated translocation of the epithelial Na(+) channel to the cell surface. J Clin Invest 105: 45–53.
42. Snyder PM. 2005. Minireview: Regulation of epithelial Na + channel trafficking. Endocrinology 146: 5079–5085.
43. Snyder PM, Olson DR, Kabra R, Zhou R, Steines JC. 2004. cAMP and serum and glucocorticoid‐inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4‐2. J Biol Chem 279: 45753–45758.
44. Thomas CP, Campbell JR, Wright PJ, Husted RF. 2004. cAMP‐stimulated Na + transport in H441 distal lung epithelial cells: Role of PKA, phosphatidylinositol 3‐kinase, and sgk1. Am J Physiol 287: L843–L851.
45. Tohda H, Foskett JK, O'Brodovich H, Marunaka Y. 1994. Cl‐ regulation of a Ca(2+)‐activated nonselective cation channel in beta‐agonist‐treated fetal distal lung epithelium. Am J Physiol 266: C104–C109.
46. Vossler MR, Yao H, York RD, Pan MG, Rim CS, Stork PJ. 1997. cAMP activates MAP kinase and Elk‐1 through a B‐Raf‐ and Rap1‐dependent pathway. Cell 89: 73–82.
47. Walters DV, Olver RE. 1978. The role of catecholamines in lung liquid absorption at birth. Pediatr Res 12: 239–242.
48. Zentner MD, Lin HH, Wen X, Kim KJ, Ann DK. 1998. The amiloride‐sensitive epithelial sodium channel alpha‐subunit is transcriptionally down‐regulated in rat parotid cells by the extracellular signal‐regulated protein kinase pathway. J Biol Chem 273: 30770–30776.