Simultaneous determination of sulfamethoxazole and trimethoprim in biological fluids for high-throughput analysis: Comparison of HPLC with ultraviolet and tandem mass spectrometric detection

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 863, Issue 1, 2008, Pages 46-54

  Bedor, D C G ^a   Goncalves T M ^a   Ferreira, M L L ^a   de Sousa, C E M ^a   Menezes, A L ^a   Oliveira, E J ^b   de Santana, D P ^a  

^a Núcleo de Desenvolvimento Farmacêutico e Cosmético ^*  (Brazil)

^b FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

High throughput; SPE LC MS MS; SPE LC UV; Sulfamethoxazole; Trimethoprim

Indexed keywords

LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; STATISTICAL METHODS;

BIOLOGICAL FLUIDS; STANDARD DEVIATION; TANDEM MASS SPECTROMETRIC DETECTION;

FLUIDS;

SULFAMETHOXAZOLE; TRIMETHOPRIM;

ADULT; ARTICLE; BODY FLUID; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; INTERMETHOD COMPARISON; ONLINE ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SAMPLE; SOLID PHASE EXTRACTION; SPECTROPHOTOMETER; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ADOLESCENT; ADULT; ANTI-INFECTIVE AGENTS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; FEMALE; HUMANS; INDICATORS AND REAGENTS; MALE; MIDDLE AGED; QUALITY CONTROL; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET; TANDEM MASS SPECTROMETRY; THERAPEUTIC EQUIVALENCY; TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION;

EID: 39149103378     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.12.027     Document Type: Article

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