메뉴 건너뛰기




Volumn 8, Issue , 2007, Pages

Codon-triplet context unveils unique features of the Candida albicans protein coding genome

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; FUNGAL RNA; TRANSFER RNA; MESSENGER RNA;

EID: 39149103111     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-8-444     Document Type: Article
Times cited : (9)

References (50)
  • 1
    • 0030564828 scopus 로고    scopus 로고
    • Co-variation of tRNA abundance and codon usage in Escherichia coli at different growth rates
    • 10.1006/jmbi.1996.0428 8709146
    • Dong H Nilsson L Kurland CG Co-variation of tRNA abundance and codon usage in Escherichia coli at different growth rates J Mol Biol 1996, 260:649-663 10.1006/jmbi.1996.0428 8709146
    • (1996) J Mol Biol , vol.260 , pp. 649-663
    • Dong, H.1    Nilsson, L.2    Kurland, C.G.3
  • 2
    • 0031805147 scopus 로고    scopus 로고
    • How optimized is the translational machinery in Escherichia coli, Salmonella typhimurium and Saccharomyces cerevisiae?
    • 1460137 9584084
    • Xia X How optimized is the translational machinery in Escherichia coli, Salmonella typhimurium and Saccharomyces cerevisiae? Genetics 1998, 149:37-44 1460137 9584084
    • (1998) Genetics , vol.149 , pp. 37-44
    • Xia, X.1
  • 3
    • 0034821884 scopus 로고    scopus 로고
    • Codon usage and tRNA genes in eukaryotes: Correlation of codon usage diversity with translation efficiency and with CG-dinucleotide usage as assessed by multivariate analysis
    • 10.1007/s002390010219 11675589
    • Kanaya S Yamada Y Kinouchi M Kudo Y Ikemura T Codon usage and tRNA genes in eukaryotes: Correlation of codon usage diversity with translation efficiency and with CG-dinucleotide usage as assessed by multivariate analysis J Mol Evol 2001, 53:290-298 10.1007/s002390010219 11675589
    • (2001) J Mol Evol , vol.53 , pp. 290-298
    • Kanaya, S.1    Yamada, Y.2    Kinouchi, M.3    Kudo, Y.4    Ikemura, T.5
  • 5
    • 0038620436 scopus 로고    scopus 로고
    • Codon pairs in the genome of Escherichia coli
    • 10.1093/bioinformatics/btg082 12761062
    • Boycheva S Chkodrov G Ivanov I Codon pairs in the genome of Escherichia coli Bioinformatics 2003, 19:987-998 10.1093/bioinformatics/btg082 12761062
    • (2003) Bioinformatics , vol.19 , pp. 987-998
    • Boycheva, S.1    Chkodrov, G.2    Ivanov, I.3
  • 6
    • 0021633530 scopus 로고
    • Codon context effects in missense suppression
    • 10.1016/0022-2836(84)90442-X 6374155
    • Murgola EJ Pagel FT Hijazi KA Codon context effects in missense suppression J Mol Biol 1984, 175:19-27 10.1016/0022-2836(84)90442-X 6374155
    • (1984) J Mol Biol , vol.175 , pp. 19-27
    • Murgola, E.J.1    Pagel, F.T.2    Hijazi, K.A.3
  • 7
    • 1342286071 scopus 로고    scopus 로고
    • The major 5′ determinant in stop codon read-through involves two adjacent adenines
    • 373328 14736996 10.1093/nar/gkh201
    • Tork S Hatin I Rousset JP Fabret C The major 5′ determinant in stop codon read-through involves two adjacent adenines Nucleic Acids Res 2004, 32:415-421 373328 14736996 10.1093/nar/gkh201
    • (2004) Nucleic Acids Res , vol.32 , pp. 415-421
    • Tork, S.1    Hatin, I.2    Rousset, J.P.3    Fabret, C.4
  • 8
    • 0036677820 scopus 로고    scopus 로고
    • Computational identification of putative programmed translational frameshift sites
    • 10.1093/bioinformatics/18.8.1046 12176827
    • Shah AA Giddings MC Gesteland RF Atkins JF Ivanov IP Computational identification of putative programmed translational frameshift sites Bioinformatics 2002, 18:1046-1053 10.1093/bioinformatics/18.8.1046 12176827
    • (2002) Bioinformatics , vol.18 , pp. 1046-1053
    • Shah, A.A.1    Giddings, M.C.2    Gesteland, R.F.3    Atkins, J.F.4    Ivanov, I.P.5
  • 9
    • 0029162727 scopus 로고
    • Codon pair utilization biases influence translational elongation step times
    • 10.1074/jbc.270.39.22801 7559409
    • Irwin B Heck JD Hatfield GW Codon pair utilization biases influence translational elongation step times J Biol Chem 1995, 270:22801-22806 10.1074/jbc.270.39.22801 7559409
    • (1995) J Biol Chem , vol.270 , pp. 22801-22806
    • Irwin, B.1    Heck, J.D.2    Hatfield, G.W.3
  • 10
    • 0036203203 scopus 로고    scopus 로고
    • Influence of the stacking potential of the base 3′ of tandem shift codons on -1 ribosomal frameshifting used for gene expression
    • 1370227 11871658 10.1017/S1355838202012086
    • Bertrand C Prere MF Gesteland RF Atkins JF Fayet O Influence of the stacking potential of the base 3′ of tandem shift codons on -1 ribosomal frameshifting used for gene expression RNA 2002, 8:16-28 1370227 11871658 10.1017/S1355838202012086
    • (2002) RNA , vol.8 , pp. 16-28
    • Bertrand, C.1    Prere, M.F.2    Gesteland, R.F.3    Atkins, J.F.4    Fayet, O.5
  • 11
    • 0000180402 scopus 로고
    • Three tRNA binding sites on Escherichia coli ribosomes
    • 348734 7029532 10.1073/pnas.78.9.5310
    • Rheinberger HJ Sternbach H Nierhaus KH Three tRNA binding sites on Escherichia coli ribosomes Proc Natl Acad Sci USA 1981, 78:5310-5314 348734 7029532 10.1073/pnas.78.9.5310
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 5310-5314
    • Rheinberger, H.J.1    Sternbach, H.2    Nierhaus, K.H.3
  • 12
    • 0001906930 scopus 로고
    • Binding of transfer ribonucleic acid to ribosomes engaged in protein synthesis: Number and properties of ribosomal binding sites
    • 14255759
    • Wettstein FO Noll H Binding of transfer ribonucleic acid to ribosomes engaged in protein synthesis: Number and properties of ribosomal binding sites J Mol Biol 1965, 11:35-53 14255759
    • (1965) J Mol Biol , vol.11 , pp. 35-53
    • Wettstein, F.O.1    Noll, H.2
  • 13
    • 0025280137 scopus 로고
    • The allosteric three-site model for the ribosomal elongation cycle: Features and future
    • 10.1021/bi00473a001 2198935
    • Nierhaus KH The allosteric three-site model for the ribosomal elongation cycle: Features and future Biochemistry 1990, 29:4997-5008 10.1021/ bi00473a001 2198935
    • (1990) Biochemistry , vol.29 , pp. 4997-5008
    • Nierhaus, K.H.1
  • 14
    • 33747878071 scopus 로고    scopus 로고
    • Decoding errors and the involvement of the E-site
    • 10.1016/j.biochi.2006.02.009 16644089
    • Nierhaus KH Decoding errors and the involvement of the E-site Biochimie 2006, 88:1013-1019 10.1016/j.biochi.2006.02.009 16644089
    • (2006) Biochimie , vol.88 , pp. 1013-1019
    • Nierhaus, K.H.1
  • 15
    • 33845484606 scopus 로고    scopus 로고
    • The E-site story: The importance of maintaining two tRNAs on the ribosome during protein synthesis
    • 10.1007/s00018-006-6125-4 17013564
    • Wilson DN Nierhaus KH The E-site story: The importance of maintaining two tRNAs on the ribosome during protein synthesis Cell Mol Life Sci 2006, 63:2725-2737 10.1007/s00018-006-6125-4 17013564
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2725-2737
    • Wilson, D.N.1    Nierhaus, K.H.2
  • 16
    • 33748582906 scopus 로고    scopus 로고
    • Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements
    • 10.1016/j.cell.2006.08.032 16962654
    • Korostelev A Trakhanov S Laurberg M Noller HF Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements Cell 2006, 126:1065-1077 10.1016/j.cell.2006.08.032 16962654
    • (2006) Cell , vol.126 , pp. 1065-1077
    • Korostelev, A.1    Trakhanov, S.2    Laurberg, M.3    Noller, H.F.4
  • 20
    • 0027260944 scopus 로고
    • Non-universal decoding of the leucine codon CUG in several Candida species
    • 309997 8371978 10.1093/nar/21.17.4039
    • Ohama T Suzuki T Mori M Osawa S Ueda T Watanabe K Nakase T Non-universal decoding of the leucine codon CUG in several Candida species Nucleic Acids Res 1993, 21:4039-4045 309997 8371978 10.1093/nar/21.17.4039
    • (1993) Nucleic Acids Res , vol.21 , pp. 4039-4045
    • Ohama, T.1    Suzuki, T.2    Mori, M.3    Osawa, S.4    Ueda, T.5    Watanabe, K.6    Nakase, T.7
  • 21
    • 0029045375 scopus 로고
    • The CUG codon is decoded in vivo as serine and not leucine in Candida albicans
    • 306886 7784200 10.1093/nar/23.9.1481
    • Santos MAS Tuite MF The CUG codon is decoded in vivo as serine and not leucine in Candida albicans Nucleic Acids Res 1995, 23:1481-1486 306886 7784200 10.1093/nar/23.9.1481
    • (1995) Nucleic Acids Res , vol.23 , pp. 1481-1486
    • Santos, M.A.S.1    Tuite, M.F.2
  • 22
    • 0033375377 scopus 로고    scopus 로고
    • Nonuniversal usage of the leucine CUG codon in yeasts: Investigation of basidiomycetous yeast
    • 10.2323/jgam.45.193 12501377
    • Sugita T Nakase T Nonuniversal usage of the leucine CUG codon in yeasts: Investigation of basidiomycetous yeast J Gen Appl Microbiol 1999, 45:193-197 10.2323/jgam.45.193 12501377
    • (1999) J Gen Appl Microbiol , vol.45 , pp. 193-197
    • Sugita, T.1    Nakase, T.2
  • 23
    • 0023650543 scopus 로고
    • The codon Adaptation Index - A measure of directional synonymous codon usage bias, and its potential applications
    • 340524 3547335 10.1093/nar/15.3.1281
    • Sharp PM Li WH The codon Adaptation Index - a measure of directional synonymous codon usage bias, and its potential applications Nucleic Acids Res 1987, 15:1281-1295 340524 3547335 10.1093/nar/15.3.1281
    • (1987) Nucleic Acids Res , vol.15 , pp. 1281-1295
    • Sharp, P.M.1    Li, W.H.2
  • 24
    • 0025912550 scopus 로고
    • Amino acid misincorporation during high-level expression of mouse epidermal growth factor in Escherichia coli
    • 328373 1852602 10.1093/nar/19.13.3511
    • Scorer CA Carrier MJ Rosenberger RF Amino acid misincorporation during high-level expression of mouse epidermal growth factor in Escherichia coli Nucleic Acids Res 1991, 19:3511-3516 328373 1852602 10.1093/nar/ 19.13.3511
    • (1991) Nucleic Acids Res , vol.19 , pp. 3511-3516
    • Scorer, C.A.1    Carrier, M.J.2    Rosenberger, R.F.3
  • 25
    • 33845895536 scopus 로고    scopus 로고
    • The frequency of translational misreading errors in E. coli is largely determined by tRNA competition
    • 1705757 17095544 10.1261/rna.294907
    • Kramer EB Farabaugh PJ The frequency of translational misreading errors in E. coli is largely determined by tRNA competition RNA 2007, 13:87-96 1705757 17095544 10.1261/rna.294907
    • (2007) RNA , vol.13 , pp. 87-96
    • Kramer, E.B.1    Farabaugh, P.J.2
  • 26
    • 39149117967 scopus 로고    scopus 로고
    • A Genetic Code Alteration Is a Phenotype Diversity Generator in the Human Pathogen Candida albicans
    • 1991585 17912373 10.1371/journal.pone.0000996
    • Miranda I Rocha R Santos MC Mateus DD Moura GR Carreto L Santos MA A Genetic Code Alteration Is a Phenotype Diversity Generator in the Human Pathogen Candida albicans PLoS ONE 2007, 2:e996 1991585 17912373 10.1371/ journal.pone.0000996
    • (2007) PLoS ONE , vol.2
    • Miranda, I.1    Rocha, R.2    Santos, M.C.3    Mateus, D.D.4    Moura, G.R.5    Carreto, L.6    Santos, M.A.7
  • 27
    • 39149086991 scopus 로고    scopus 로고
    • A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans
    • 10.1186/gb-2007-8-10-r206 17916231
    • Gomes AC Miranda I Silva RM Moura GR Thomas B Akoulitchev A Santos MA A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans Genome Biol 2007, 8:R206 10.1186/ gb-2007-8-10-r206 17916231
    • (2007) Genome Biol , vol.8
    • Gomes, A.C.1    Miranda, I.2    Silva, R.M.3    Moura, G.R.4    Thomas, B.5    Akoulitchev, A.6    Santos, M.A.7
  • 28
    • 0034049112 scopus 로고    scopus 로고
    • Trinucleotide repeats are clustered in regulatory genes in Saccharomyces cerevisiae
    • 1460995 10757753
    • Young ET Sloan JS Van Riper K Trinucleotide repeats are clustered in regulatory genes in Saccharomyces cerevisiae Genetics 2000, 154:1053-1068 1460995 10757753
    • (2000) Genetics , vol.154 , pp. 1053-1068
    • Young, E.T.1    Sloan, J.S.2    Van Riper, K.3
  • 29
    • 0037039436 scopus 로고    scopus 로고
    • Amino acid runs in eukaryotic proteomes and disease associations
    • 117561 11782551 10.1073/pnas.012608599
    • Karlin S Brocchieri L Bergman A Mrazek J Gentles AJ Amino acid runs in eukaryotic proteomes and disease associations Proc Natl Acad Sci USA 2002, 99:333-338 117561 11782551 10.1073/pnas.012608599
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 333-338
    • Karlin, S.1    Brocchieri, L.2    Bergman, A.3    Mrazek, J.4    Gentles, A.J.5
  • 30
    • 0242417617 scopus 로고    scopus 로고
    • Comparative evolutionary genomics unveils the molecular mechanism of reassignment of the CTG codon in Candida spp
    • 430169 12670996 10.1101/gr.811003
    • Massey SE Moura G Beltrao P Almeida R Garey JR Tuite MF Santos MA Comparative evolutionary genomics unveils the molecular mechanism of reassignment of the CTG codon in Candida spp Genome Res 2003, 13:544-557 430169 12670996 10.1101/gr.811003
    • (2003) Genome Res , vol.13 , pp. 544-557
    • Massey, S.E.1    Moura, G.2    Beltrao, P.3    Almeida, R.4    Garey, J.R.5    Tuite, M.F.6    Santos, M.A.7
  • 31
    • 0037147244 scopus 로고    scopus 로고
    • Analysis of the antimalarial drug resistance protein Pfcrt expressed in yeast
    • 10.1074/jbc.M204005200 12351620
    • Zhang H Howard EM Roepe PD Analysis of the antimalarial drug resistance protein Pfcrt expressed in yeast J Biol Chem 2002, 277:49767-49775 10.1074/jbc.M204005200 12351620
    • (2002) J Biol Chem , vol.277 , pp. 49767-49775
    • Zhang, H.1    Howard, E.M.2    Roepe, P.D.3
  • 32
    • 0011051225 scopus 로고
    • Evolution of the genome and the genetic code: Selection at the dinucleotide level by methylation and polyribonucleotide cleavage
    • 286430 2463621 10.1073/pnas.86.1.192
    • Beutler E Gelbart T Han JH Koziol JA Beutler B Evolution of the genome and the genetic code: Selection at the dinucleotide level by methylation and polyribonucleotide cleavage Proc Natl Acad Sci USA 1989, 86:192-196 286430 2463621 10.1073/pnas.86.1.192
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 192-196
    • Beutler, E.1    Gelbart, T.2    Han, J.H.3    Koziol, J.A.4    Beutler, B.5
  • 33
    • 36549060956 scopus 로고    scopus 로고
    • Computational and Statistical Methodologies for ORFeome Primary Structure Analysis
    • 17993691
    • Moura G Pinheiro M Freitas AV Oliveira JL Santos MA Computational and Statistical Methodologies for ORFeome Primary Structure Analysis Methods Mol Biol 2007, 395:449-462 17993691
    • (2007) Methods Mol Biol , vol.395 , pp. 449-462
    • Moura, G.1    Pinheiro, M.2    Freitas, A.V.3    Oliveira, J.L.4    Santos, M.A.5
  • 34
    • 0032581609 scopus 로고    scopus 로고
    • Codon usage in highly expressed genes of Haemophillus influenzae and Mycobacterium tuberculosis: Translational selection versus mutational bias
    • 10.1016/S0378-1119(98)00257-1 9714839
    • Pan A Dutta C Das J Codon usage in highly expressed genes of Haemophillus influenzae and Mycobacterium tuberculosis: Translational selection versus mutational bias Gene 1998, 215:405-413 10.1016/ S0378-1119(98)00257-1 9714839
    • (1998) Gene , vol.215 , pp. 405-413
    • Pan, A.1    Dutta, C.2    Das, J.3
  • 35
    • 0034736516 scopus 로고    scopus 로고
    • Second codon positions of genes and the secondary structures of proteins. Relationships and implications for the origin of the genetic code
    • 10.1016/S0378-1119(00)00521-7 11164038
    • Chiusano ML Alvarez VF Di Giulio M D' Onofrio G Ammirato G Colonna G Bernardi G Second codon positions of genes and the secondary structures of proteins. Relationships and implications for the origin of the genetic code Gene 2000, 261:63-69 10.1016/S0378-1119(00)00521-7 11164038
    • (2000) Gene , vol.261 , pp. 63-69
    • Chiusano, M.L.1    Alvarez, V.F.2    Di Giulio, M.3    D' Onofrio, G.4    Ammirato, G.5    Colonna, G.6    Bernardi, G.7
  • 36
    • 0036567071 scopus 로고    scopus 로고
    • Over-representation of repeats in stress response genes: A strategy to increase versatility under stressful conditions?
    • 113848 11972324 10.1093/nar/30.9.1886
    • Rocha EP Matic I Taddei F Over-representation of repeats in stress response genes: A strategy to increase versatility under stressful conditions? Nucleic Acids Res 2002, 30:1886-1894 113848 11972324 10.1093/ nar/30.9.1886
    • (2002) Nucleic Acids Res , vol.30 , pp. 1886-1894
    • Rocha, E.P.1    Matic, I.2    Taddei, F.3
  • 37
    • 0036072745 scopus 로고    scopus 로고
    • Tandem repeats in protein coding regions of primate genes
    • 1383732 12045144 10.1101/gr.138802
    • Borstnik B Pumpernik D Tandem repeats in protein coding regions of primate genes Genome Res 2002, 12:909-915 1383732 12045144 10.1101/ gr.138802
    • (2002) Genome Res , vol.12 , pp. 909-915
    • Borstnik, B.1    Pumpernik, D.2
  • 38
    • 0030785576 scopus 로고    scopus 로고
    • Analyses of frameshifting at UUU-pyrimidine sites
    • 146683 9115369 10.1093/nar/25.10.2005
    • Schwartz R Curran JF Analyses of frameshifting at UUU-pyrimidine sites Nucleic Acids Res 1997, 25:2005-2011 146683 9115369 10.1093/nar/ 25.10.2005
    • (1997) Nucleic Acids Res , vol.25 , pp. 2005-2011
    • Schwartz, R.1    Curran, J.F.2
  • 39
    • 0028175762 scopus 로고
    • The second to last amino acid in the nascent peptide as a codon context determinant
    • 394799 8306967
    • Mottagui-Tabar S Bjornsson A Isaksson LA The second to last amino acid in the nascent peptide as a codon context determinant EMBO J 1994, 13:249-257 394799 8306967
    • (1994) EMBO J , vol.13 , pp. 249-257
    • Mottagui-Tabar, S.1    Bjornsson, A.2    Isaksson, L.A.3
  • 40
    • 0030854739 scopus 로고    scopus 로고
    • tRNAscan-SE: A program for improved detection of transfer RNA genes in genomic sequence
    • 146525 9023104 10.1093/nar/25.5.955
    • Lowe TM Eddy SR tRNAscan-SE: A program for improved detection of transfer RNA genes in genomic sequence Nucleic Acids Res 1997, 25:955-964 146525 9023104 10.1093/nar/25.5.955
    • (1997) Nucleic Acids Res , vol.25 , pp. 955-964
    • Lowe, T.M.1    Eddy, S.R.2
  • 41
    • 0023900428 scopus 로고
    • Transcription by RNA polymerase III
    • 10.1146/annurev.bi.57.070188.004301 3052292
    • Geiduschek EP Tocchini-Valentini GP Transcription by RNA polymerase III Annu Rev Biochem 1988, 57:873-914 10.1146/annurev.bi.57.070188.004301 3052292
    • (1988) Annu Rev Biochem , vol.57 , pp. 873-914
    • Geiduschek, E.P.1    Tocchini-Valentini, G.P.2
  • 42
    • 39149124775 scopus 로고    scopus 로고
    • ftp://ftp.ncbi.nih.gov/genomes/Fungi/Aspergillus_fumigatus/
    • NCBI Genbank Link for Aspergillus fumigatus ftp://ftp.ncbi.nih.gov/ genomes/Fungi/Aspergillus_fumigatus/
    • NCBI Genbank Link for Aspergillus Fumigatus
  • 43
    • 34547395323 scopus 로고    scopus 로고
    • Candida Genome Database http://www.candidagenome.org/download/sequence/ Assembly19/archived_as_released/
    • Candida Genome Database
  • 44
    • 39149084969 scopus 로고    scopus 로고
    • ftp://ftp.ncbi.nih.gov/genomes/Fungi/Candida_glabrata_CBS138/
    • NCBI Genbank Link for Candida glabrata ftp://ftp.ncbi.nih.gov/genomes/ Fungi/Candida_glabrata_CBS138/
    • NCBI Genbank Link for Candida Glabrata
  • 45
    • 39149109113 scopus 로고    scopus 로고
    • ftp://ftp.ncbi.nih.gov/genomes/Fungi/Debaryomyces_hansenii_CBS767/
    • NCBI Genbank Link for Debaryomyces hansenii ftp://ftp.ncbi.nih.gov/ genomes/Fungi/Debaryomyces_hansenii_CBS767/
    • NCBI Genbank Link for Debaryomyces Hansenii
  • 46
    • 39149087319 scopus 로고    scopus 로고
    • ftp://ftp.ncbi.nih.gov/genomes/Fungi/Eremothecium_gossypii/
    • NCBI Genbank Link for Eremothecium gossypii ftp://ftp.ncbi.nih.gov/ genomes/Fungi/Eremothecium_gossypii/
    • NCBI Genbank Link for Eremothecium Gossypii
  • 47
    • 39149107741 scopus 로고    scopus 로고
    • ftp://ftp.ncbi.nih.gov/genomes/Fungi/Kluyveromyces_lactis_NRRL_Y-1140/
    • NCBI Genbank Link for Kluyveromyces lactis ftp://ftp.ncbi.nih.gov/ genomes/Fungi/Kluyveromyces_lactis_NRRL_Y-1140/
    • NCBI Genbank Link for Kluyveromyces Lactis
  • 48
  • 49
    • 39149122138 scopus 로고    scopus 로고
    • ftp://ftp.ncbi.nih.gov/genomes/Fungi/Saccharomyces_cerevisiae/
    • NCBI Genbank Link for Saccharomyces cerevisiae ftp://ftp.ncbi.nih.gov/ genomes/Fungi/Saccharomyces_cerevisiae/
    • NCBI Genbank Link for Saccharomyces Cerevisiae
  • 50


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.