Can sparsely and heterogeneously expressed proteins be detected using tissue microarrays? A simulation study of the hypoxia marker carbonic anhydrase IX (CA IX) in human soft tissue sarcoma

Pathology Research and Practice

Volumn 204, Issue 3, 2008, Pages 175-183

  Måseide, Kårstein ^a,c   Pintilie, Melania ^a   Kandel, Rita ^b,c   Hill, Richard P ^a,c  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Hypoxia; Limited sampling Ca IX; Soft tissue sarcoma; Tissue microarray

Indexed keywords

BIOLOGICAL MARKER; CARBONATE DEHYDRATASE IX;

ARTICLE; CANCER GRADING; CLINICAL ARTICLE; CRITERION VARIABLE; DIAGNOSTIC ACCURACY; FALSE POSITIVE RESULT; GENETIC HETEROGENEITY; HUMAN; HUMAN TISSUE; HYPOXIA; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; PROBABILITY; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SAMPLING; SENSITIVITY ANALYSIS; SIMULATION; SOFT TISSUE SARCOMA; TISSUE MICROARRAY; TUMOR BIOPSY; TUMOR CLASSIFICATION; TUMOR LOCALIZATION;

ANTIGENS, NEOPLASM; BIOPSY; CARBONIC ANHYDRASES; FALSE POSITIVE REACTIONS; HUMANS; KAPLAN-MEIERS ESTIMATE; SARCOMA; SENSITIVITY AND SPECIFICITY; SOFT TISSUE NEOPLASMS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 39149093976     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2007.10.009     Document Type: Article

References (16)

1. Cline J.M., Rosner G.L., Raleigh J.A., and Thrall D.E. Quantification of CCI-103F labeling heterogeneity in canine solid tumors. Int. J. Radiat. Oncol. Biol. Phys. 37 (1997) 655-662
2. Engellau J., Akerman M., Anderson H., Domanski H.A., Rambech E., Alvegard T.A., and Nilbert M. Tissue microarray technique in soft tissue sarcoma: immunohistochemical Ki-67 expression in malignant fibrous histiocytoma. Appl. Immunohistochem. Mol. Morphol. 9 (2001) 358-363
3. Francis P., Fernebro J., Eden P., Laurell A., Rydholm A., Domanski H.A., Breslin T., Hegardt C., Borg A., and Nilbert M. Intratumor versus intertumor heterogeneity in gene expression profiles of soft-tissue sarcomas. Genes Chromosome Cancer 43 (2005) 302-308
4. Hoos A., Urist M.J., Stojadinovic A., Mastorides S., Dudas M.E., Leung D.H., Kuo D., Brennan M.F., Lewis J.J., and Cordon-Cardo C. Validation of tissue microarrays for immunohistochemical profiling of cancer specimens using the example of human fibroblastic tumors. Am. J. Pathol. 158 (2001) 1245-1251
5. Kononen J., Bubendorf L., Kallioniemi A., Barlund M., Schraml P., Leighton S., Torhorst J., Mihatsch M.J., Sauter G., and Kallioniemi O.P. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat. Med. 4 (1998) 844-847
6. Måseide K., Kandel R.A., Bell R.S., Catton C.N., O'Sullivan B., Wunder J.S., Pintilie M., Hedley D., and Hill R.P. Carbonic anhydrase IX as a marker for poor prognosis in soft tissue sarcoma. Clin. Cancer Res. 10 (2004) 4464-4471
7. Mucci N.R., Akdas G., Manely S., and Rubin M.A. Neuroendocrine expression in metastatic prostate cancer: evaluation of high throughput tissue microarrays to detect heterogeneous protein expression. Hum. Pathol. 31 (2000) 406-414
8. Nielsen T.O., Hsu F.D., O'Connell J.X., Gilks C.B., Sorensen P.H., Linn S., West R.B., Liu C.L., Botstein D., Brown P.O., and van de Rijn M. Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology. Am. J. Pathol. 163 (2003) 1449-1456
9. Nocito A., Bubendorf L., Maria Tinner E., Suess K., Wagner U., Forster T., Kononen J., Fijan A., Bruderer J., Schmid U., Ackermann D., Maurer R., Alund G., Knonagel H., Rist M., Anabitarte M., Hering F., Hardmeier T., Schoenenberger A.J., Flury R., Jager P., Luc Fehr J., Schraml P., Moch H., Mihatsch M.J., Gasser T., and Sauter G. Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade. J. Pathol. 194 (2001) 349-357
10. Pacifico M.D., Grover R., Richman P., Daley F., and Wilson G.D. Validation of tissue microarray for the immunohistochemical profiling of melanoma. Melanoma Res. 14 (2004) 39-42
11. Rubin M.A., Dunn R., Strawderman M., and Pienta K.J. Tissue microarray sampling strategy for prostate cancer biomarker analysis. Am. J. Surg. Pathol. 26 (2002) 312-319
12. Subarsky P., and Hill R.P. The hypoxic tumour microenvironment and metastatic progression. Clin. Exp. Metastasis 20 (2003) 237-250
13. Svrcek M., Jourdan F., Sebbagh N., Couvelard A., Chatelain D., Mourra N., Olschwang S., Wendum D., and Flejou J.F. Immunohistochemical analysis of adenocarcinoma of the small intestine: a tissue microarray study. J. Clin. Pathol. 56 (2003) 898-903
14. Torhorst J., Bucher C., Kononen J., Haas P., Zuber M., Kochli O.R., Mross F., Dieterich H., Moch H., Mihatsch M., Kallioniemi O.P., and Sauter G. Tissue microarrays for rapid linking of molecular changes to clinical endpoints. Am. J. Pathol. 159 (2001) 2249-2256
15. Zellweger T., Ninck C., Bloch M., Mirlacher M., Koivisto P.A., Helin H.J., Mihatsch M.J., Gasser T.C., and Bubendorf L. Expression patterns of potential therapeutic targets in prostate cancer. Int. J. Cancer 113 (2005) 619-628
16. Zhang D., Salto-Tellez M., Do E., Putti T.C., and Koay E.S. Evaluation of HER-2/neu oncogene status in breast tumors on tissue microarrays. Hum. Pathol. 34 (2003) 362-368