Is experimental endotoxaemia in humans suitable for simulating antibiotic pharmacokinetics in sepsis and septic shock?. A pilot study using the model compound fosfomycin

International Journal of Antimicrobial Agents

Volumn 31, Issue 3, 2008, Pages 291-292

  Sauermann, Robert ^a   Mayer Helm, Bernhard X ^a   Petsch, Martina ^a   Popovic, Martin ^a   Thallinger, Christiane ^a   Joukhadar, Christian ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FOSFOMYCIN;

ANTIBIOTIC THERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG INFUSION; DRUG TISSUE LEVEL; ENDOTOXEMIA; EXPERIMENTAL INFECTION; HUMAN; LETTER; MALE; PILOT STUDY; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK;

ANTI-BACTERIAL AGENTS; ENDOTOXEMIA; FOSFOMYCIN; HUMANS; LIPOPOLYSACCHARIDES; MALE; PILOT PROJECTS; SEPSIS; SHOCK, SEPTIC;

EID: 39149091720     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2007.10.018     Document Type: Letter

References (7)

1. Joukhadar C., Frossard M., Mayer B.X., Brunner M., Klein N., Siostrzonek P., et al. Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock. Crit Care Med 29 (2001) 385-391
2. European Parliament and the European Council. Directive 2001/20/EC. Off J Eur Comm 2001;L 121:34-44.
3. Silverman H.J., Druml C., Lemaire F., and Nelson R. The European Union Directive and the protection of incapacitated subjects in research: an ethical analysis. Intensive Care Med 30 (2004) 1723-1729
4. Mayr F.B., Spiel A., Leitner J., Marsik C., Germann P., Ullrich R., et al. Effects of carbon monoxide inhalation during experimental endotoxemia in humans. Am J Respir Crit Care Med 171 (2005) 354-360
5. Joukhadar C., Klein N., Dittrich P., Zeitlinger M., Geppert A., Skhirtladze K., et al. Target site penetration of fosfomycin in critically ill patients. J Antimicrob Chemother 51 (2003) 1247-1252
6. Petsch M., Mayer-Helm B.X., Sauermann R., Joukhadar C., and Kenndler E. Capillary electrophoresis analysis of fosfomycin in biological fluids for clinical pharmacokinetic studies. Electrophoresis 25 (2004) 2292-2298
7. Kinzig M., Sorgel F., Brismar B., and Nord C.E. Pharmacokinetics and tissue penetration of tazobactam and piperacillin in patients undergoing colorectal surgery. Antimicrob Agents Chemother 36 (1992) 1997-2004