Association of alcohol abuse and injection drug use with immunologic and virologic responses to HAART in HIV-positive patients from urban community health clinics

Journal of Community Health

Volumn 33, Issue 2, 2008, Pages 69-77

  Henrich, Timothy J ^a   Lauder, Naudia ^b   Desai, Mayur M ^c   Sofair, Andre N ^c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol abuse; Antiretroviral therapy; HIV infection; Intravenous drug use; Substance abuse

Indexed keywords

ALCOHOL; ANTIRETROVIRUS AGENT; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ADULT; ALCOHOL ABUSE; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEALTH CENTER; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INTRAVENOUS DRUG ABUSE; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NONHUMAN; RETROSPECTIVE STUDY; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; SUBSTANCE ABUSE; URBAN POPULATION; VIROLOGY; VIRUS LOAD;

AGE FACTORS; ALCOHOLISM; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; COMMUNITY HEALTH SERVICES; FEMALE; HIV SEROPOSITIVITY; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SEX FACTORS; SOCIOECONOMIC FACTORS; SUBSTANCE ABUSE, INTRAVENOUS; URBAN HEALTH SERVICES; VIRAL LOAD;

EID: 39149088032     PISSN: 00945145     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10900-007-9069-1     Document Type: Article

References (38)

1. Hammer, S. M., Squires, K. E., Hughes, M. D., Grimes, J. M., Demeter, L. M., Currier, J. S., et al. (1997). A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. New England Journal of Medicine, 337, 725-733.
2. Montaner, J. S., Reiss, P., Cooper, D., Vella, S., Harris, M., Conway, B., et al. (1998). A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients: the INCAS Trial. Italy, The Netherlands, Canada and Australia Study. Journal of the American Medical Association, 279, 930-937.
3. Hinkin, C. H., Hardy, D. J., Mason, K. I., Castellon, S. A., Durvasula, R. S., Lam, M. N., et al. (2004). Medication adherence in HIV-infected adults: Effect of patient age, cognitive status, and substance abuse. Aids, 18, S19-S25.
4. Lucas, G. M., Cheever, L. W., Chaisson, R. E., & Moore, R. D. (2001). Detrimental effects of continued illicit drug use on the treatment of HIV-1 infection. Journal of Acquired Immune Deficiency Syndromes, 27, 251-259.
5. Egea, J. M., Muga, R., Sirera, G., Clotet, B., Tor, J., Ardevol, M., et al. (2002). Initiation, changes in use and effectiveness of highly active anti-retroviral therapy in a cohort of injecting drug users. Epidemiology and Infection, 129, 325-333.
6. Palepu, A., Horton, N. J., Tibbetts, N., Meli, S., & Samet, J. H. (2004). Uptake and adherence to highly active antiretroviral therapy among HIV-infected people with alcohol and other substance use problems: The impact of substance abuse treatment. Addiction, 99, 361-368.
7. Mocroft, A., Madge, S., Johnson, A. M., Lazzarin, A., Clumeck, N., Goebel, F. D., et al. (1999). A comparison of exposure groups in the EuroSIDA study: Starting highly active antiretroviral therapy (HAART), response to HAART, and survival. Journal of Acquired Immune Deficiency Syndromes, 22, 369-378.
8. Roca, B., Gomez, C. J., & Arnedo, A. (1999). Stavudine, lamivudine and indinavir in drug abusing and non-drug abusing HIV-infected patients: adherence, side effects and efficacy. Journal of Infection, 39, 141-145.
9. Bouhnik, A. D., Chesney, M., Carrieri, P., Gallais, H., Moreau, J., Moatti, J. P., et al. (2002). Nonadherence among HIV-infected injecting drug users: The impact of social instability. Journal of Acquired Immune Deficiency Syndromes, 31, S149-S153.
10. Stein, M. D., Rich, J. D., Maksad, J., Chen, M. H., Hu, P., Sobota, M., et al. (2000). Adherence to antiretroviral therapy among HIV-infected methadone patients: Effect of ongoing illicit drug use. American Journal of Drug and Alcohol Abuse, 26, 195-205.
11. Sharpe, T. T., Lee, L. M., Nakashima, A. K., Elam-Evans, L. D., & Fleming, P. L. (2004). Crack cocaine use and adherence to antiretroviral treatment among HIV-infected black women. Journal of Community Health, 29, 117-127.
12. Arnsten, J. H., Demas, P. A., Grant, R. W., Gourevitch, M. N., Farzadegan, H., Howard, A. A., et al. (2002). Impact of active drug use on antiretroviral therapy adherence and viral suppression in HIV-infected drug users. Journal of General Internal Medicine, 17, 377-381.
13. Tucker, J. S., Burnam, M. A., Sherbourne, C. D., Kung, F. Y., & Gifford, A. L. (2003). Substance use and mental health correlates of nonadherence to antiretroviral medications in a sample of patients with human immunodeficiency virus infection. American Journal of Medicine, 114, 573-580.
14. Wood, E., Montaner, J. S., Yip, B., Tyndall, M. W., Schechter, M. T., O'Shaughnessy, M. V., et al. (2004). Adherence to antiretroviral therapy and CD4 T-cell count responses among HIV-infected injection drug users. Antiviral Therapy, 9, 229-235.
15. Zaccarelli, M., Barracchini, A., De Longis, P., Perno, C. F., Soldani, F., Liuzzi, G., et al. (2002). Factors related to virologic failure among HIV-positive injecting drug users treated with combination antiretroviral therapy including two nucleoside reverse transcriptase inhibitors and nevirapine. AIDS Patient Care STDS, 16, 67-73.
16. Dragsted, U. B., Mocroft, A., Vella, S., Viard, J. P., Hansen, A. B., Panos, G., et al. (2004). Predictors of immunological failure after initial response to highly active antiretroviral therapy in HIV-1-infected adults: A EuroSIDA study. Journal of Infectious Diseases, 190, 148-155.
17. Palepu, A., Tyndall, M., Yip, B., O'Shaughnessy, M. V., Hogg, R. S., & Montaner, J. S. (2003). Impaired virologic response to highly active antiretroviral therapy associated with ongoing injection drug use. Journal of Acquired Immune Deficiency Syndromes, 32, 522-526.
18. Ellis, R. J., Childers, M. E., Cherner, M., Lazzaretto, D., Letendre, S., & Grant, I. (2003). Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapy. Journal of Infectious Diseases, 188, 1820-1826.
19. Mohammed, H., Kieltyka, L., Richardson-Alston, G., Magnus, M., Fawal, H., Vermund, S. H., et al. (2004). Adherence to HAART among HIV-infected persons in rural Louisiana. AIDS Patient Care STDS, 18, 289-296.
20. Samet, J. H., Horton, N. J., Meli, S., Freedberg, K. A., & Palepu, A. (2004). Alcohol consumption and antiretroviral adherence among HIV-infected persons with alcohol problems. Alcoholism-Clinical and Experimental Research, 28, 572-577.
21. Miguez, M. J., Shor-Posner, G., Morales, G., Rodriguez, A., & Burbano, X. (2003). HIV treatment in drug abusers: Impact of alcohol use. Addiction Biology, 8, 33-37.
22. From the Centers for Disease Control and prevention. (1993). 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Journal of the American Medical Association, 269, 460.
23. McDavid, K., & McKenna, M. T. (2006). HIV/AIDS risk factor ascertainment: A critical challenge. AIDS Patient Care STDS, 20, 285-292.
24. Moore, A. L., Kirk, O., Johnson, A. M., Katlama, C., Blaxhult, A., Dietrich, M., et al. (2003). Virologic, immunologic, and clinical response to highly active antiretroviral therapy: The gender issue revisited. Journal of Acquired Immune Deficiency Syndromes, 32, 452-461.
25. Goodkin, K., Shapshak, P., Asthana, D., Zheng, W., Concha, M., Wilkie, F. L., et al. (2004). Older age and plasma viral load in HIV-1 infection. Aids, 18, S87-S98.
26. Wagner, G. J., & Ryan, G. W. (2004). Relationship between routinization of daily behaviors and medication adherence in HIV-positive drug users. AIDS Patient Care STDS, 18, 385-393.
27. Murphy, D. A., Marelich, W. D., Hoffman, D., & Steers, W. N. (2004). Predictors of antiretroviral adherence. AIDS Care, 16, 471-484.
28. Turner, B. J., Fleishman, J. A., Wenger, N., London, A. S., Burnam, M. A., Shapiro, M. F., et al. (2001). Effects of drug abuse and mental disorders on use and type of antiretroviral therapy in HIV-infected persons. Journal of General Internal Medicine, 16, 625-633.
29. Cook, J. A., Grey, D., Burke, J., Cohen, M. H., Gurtman, A. C., Richardson, J. L., et al. (2004). Depressive symptoms and AIDS-related mortality among a multisite cohort of HIV-positive women. American Journal of Public Health, 94, 1133-1140.
30. Lehman, A. F., Myers, C. P., Corty, E., & Thompson, J. W. (1994). Prevalence and patterns of "dual diagnosis" among psychiatric inpatients. Comprehensive Psychiatry, 35, 106-112.
31. Powell-Cope, G. M., White, J., Henkelman, E. J., & Turner, B. J. (2003). Qualitative and quantitative assessments of HAART adherence of substance-abusing women. AIDS Care, 15, 239-249.
32. Conway, B., Prasad, J., Reynolds, R., Farley, J., Jones, M., Jutha, S., et al. (2004). Directly observed therapy for the management of HIV-infected patients in a methadone program. Clinical and Infectious Diseases, 38, S402-S408.
33. Visnegarwala, F., Rodriguez-Barradass, M. C., Graviss, E. A., Caprio, M., Nykyforchyn, M., & Laufman, L. (2006). Community outreach with weekly delivery of anti-retroviral drugs compared to cognitive-behavioural health care team-based approach to improve adherence among indigent women newly starting HAART. AIDS Care, 18, 332-338.
34. Williams, A. B., Fennie, K. P., Bova, C. A., Burgess, J. D., Danvers, K. A., & Dieckhaus, K. D. (2006). Home visits to improve adherence to highly active antiretroviral therapy: A randomized controlled trial. Journal of Acquired Immune Deficiency Syndromes, 42, 314-321.
35. Frick, P., Tapia, K., Grant, P., Novotny, M., & Kerzee, J. (2006). The effect of a multidisciplinary program on HAART adherence. AIDS Patient Care STDS, 20, 511-524.
36. Tuldra, A., & Wu, A. W. (2002). Interventions to improve adherence to antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes, 31, S154-S157.
37. McNagny, S. E., & Parker, R. M. (1992). High prevalence of recent cocaine use and the unreliability of patient self-report in an inner-city walk-in clinic. Journal of the American Medical Association, 267, 1106-1108.
38. Moore, R. D., Bone, L. R., Geller, G., Mamon, J. A., Stokes, E. J., & Levine, D. M. (1989). Prevalence, detection, and treatment of alcoholism in hospitalized patients. Journal of the American Medical Association, 261, 403-407.