Regulation of cardiac contractility: High time for FXYD

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 2, 2008, Pages

  Cheung, Joseph Y ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b Division of Nephrology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CELL MEMBRANE PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; DYSADHERIN; PHOSPHOLEMMAN; PROTEIN FXYD1; PROTEIN FXYD2; PROTEIN FXYD3; PROTEIN KINASE C; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; CARBOXY TERMINAL SEQUENCE; DEPHOSPHORYLATION; EDITORIAL; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HEART MUSCLE CONTRACTILITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS;

ANIMALS; HUMANS; MEMBRANE PROTEINS; MYOCARDIAL CONTRACTION; MYOCARDIUM; PHOSPHOPROTEINS; PROTEIN KINASES; SARCOLEMMA; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 39149083754     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.91430.2007     Document Type: Editorial

References (18)

1. Bell JR, Kennington E, Fuller W, Dighe K, Donoghue P, Clark JE, Jia LG, Tucker AL, Moorman JR, Marber MS, Eaton P, Dunn MJ, Shattock MJ. Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity. Am J Physiol Heart Circ Physiol (December 7, 2007). doi:10.1152/ajpheart.01332.2007.
2. Bossuyt J, Ai X, Moorman JR, Pogwizd SM, Bers DM. Expression and phosphorylation of the Na-pump regulatory subunit phospholemman in heart failure. Circ Res 97: 558-565, 2005.
3. 2+ exchanger by phospholemman. Ann NY Acad Sci 1099: 119-134, 2007.
4. Crambert G, Fuzesi M, Garty H, Karlish S, Geering K. Phospholemman (FXYD1) associates with Na,K-ATPase and regulates its transport properties. Proc Natl Acad Sci USA 99: 11476-11481, 2002.
5. Despa S, Bossuyt J, Han F, Ginsburg KS, Jia LG, Kutchai H, Tucker AL, Bers DM. Phospholemman-phosphorylation mediates the β-adrenergic effects on Na/K pump function in cardiac myocytes. Circ Res 97: 252-259, 2005.
6. i in a restricted space of guineapig ventricular cells. J Physiol 509: 457-470, 1998.
7. + pump function in cardiac myocytes. Circ Res 99: 1376-1383, 2006.
8. +-ATPase: α/β/FXYD subunit stoichiometry and cross-linking. J Biol Chem 281: 5947-5955, 2006.
9. Moorman JR, Ackerman SJ, Kowdley GC, Griffin M, Mounsey JP, Chen Z, Cala SE, O'Brian JJ, Szabo G, Jones LR. Unitary anion currents through phospholemman channel molecules. Nature 377: 737-740, 1995.
10. Palmer CJ, Scott BT, Jones LR. Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinase C in myocardium. J Biol Chem 266: 11126-11130, 1991.
11. Pavlovic D, Fuller W, Shattock MJ. The intracellular region of FXYD1 is sufficient to regulate cardiac Na/K ATPase. FASEB J 21: 1539-1546, 2007.
12. Presti CF, Jones LR, Lindemann JP. Isoproterenol-induced phosphorylation of a 15-kilodalton sarcolemmal protein in intact myocardium. J Biol Chem 260: 3860-3867, 1985.
13. Silverman BZ, Fuller W, Eaton P, Deng J, Moorman JR, Cheung JY, James AF, Shattock MJ. Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase. Cardiovasc Res 65: 93-103, 2005.
14. Simmerman HK, Jones LR. Phospholamban: protein structure, mechanism of action, and role in cardiac function. Physiol Rev 78: 921-947, 1998.
15. Sweadner KJ, Rael E. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Genomics 68: 41-56, 2000.
16. 2+ exchange. Am J Physiol Heart Circ Physiol 291: H2199-H2209, 2006.
17. Waalas SI, Czernik AJ, Olstad OK, Sletten K, Walaas O. Protein kinase C and cyclic AMP-dependent protein kinase phosphorylate phospholemman, an insulin and adrenaline-regulated membrane phosphoprotein, at specific sites in the carboxy terminal domain. Biochem J 304: 635-640, 1994.
18. + pump activity in postinfarction myocytes. J Appl Physiol 100: 212-220, 2006.