New insights into the pathogenicity of antiphospholipid antibodies

Japanese Journal of Clinical Immunology

Volumn 29, Issue 5, 2006, Pages 311-318

  Yasuda, Shinsuke ^a   Koike, Takao ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Antiphospholipid syndrome; P38 MAP kinase; Prothrombin; Tissue factor; 2 glycoprotein I

Indexed keywords

BETA2 GLYCOPROTEIN 1; PHOSPHOLIPID ANTIBODY; PROTHROMBIN;

ANIMAL; ANTIPHOSPHOLIPID SYNDROME; FEMALE; FIBRINOLYSIS; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; PHYSIOLOGY; PREGNANCY; REVIEW; THROMBOTIC THROMBOCYTOPENIC PURPURA;

ANIMALS; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; BETA 2-GLYCOPROTEIN I; FEMALE; FIBRINOLYSIS; HUMANS; MICE; PREGNANCY; PROTHROMBIN; PURPURA, THROMBOTIC THROMBOCYTOPENIC;

EID: 39049195706     PISSN: 09114300     EISSN: 13497413     Source Type: Journal    
DOI: 10.2177/jsci.29.311     Document Type: Article

References (25)

1. Atsumi T, Koike T.: Clinical relevance of antiprothrombin antibodies. Autoimmun Rev 1 (1–2): 49–53, 2002.
2. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al.: International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4 (2): 295–306, 2006.
3. Hashimoto Y, Kawamura M, Ichikawa K, Suzuki T, Sumida T, Yoshida S, et al.: Anticardiolipin antibodies in NZW×BXSB F1 mice. A model of antiphospholipid syndrome. J Immunol 149 (3): 1063–1068, 1992.
4. Aron AL, Cuellar ML, Brey RL, McKeown S, Espinoza LR, Shoenfeld Y, et al.: Early onset of autoimmunity in MRL/ ++ mice following immunization with beta 2 glycoprotein I. Clin Exp Immunol 101 (1): 78–81, 1995.
5. Blank M, Faden D, Tincani A, Kopolovic J, Goldberg I, Gilburd B, et al.: Immunization with anticardiolipin cofactor (beta-2-glycoprotein I) induces experimental antiphospholipid syndrome in naive mice. J Autoimmun 7 (4): 441–455, 1994.
6. Pierangeli SS, Barker JH, Stikovac D, Ackerman D, Anderson G, Barquinero J, et al.: Effect of human IgG antiphospholipid antibodies on an in vivo thrombosis model in mice. Thromb Haemost 71 (5): 670–674, 1994.
7. Fischetti F, Durigutto P, Pellis V, Debeus A, Macor P, Bulla R, et al.: Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor. Blood 106 (7): 2340–2346, 2005.
8. Robertson SA, Roberts CT, van Beijering E, Pensa K, Sheng Y, Shi T, et al.: Effect of beta2-glycoprotein I null mutation on reproductive outcome and antiphospholipid antibody-mediated pregnancy pathology in mice. Mol Hum Reprod 10 (6): 409–416, 2004.
9. Blank M, George J, Barak V, Tincani A, Koike T, Shoenfeld Y. Oral tolerance to low dose beta 2-glycoprotein I: Immunomodulation of experimental antiphospholipid syndrome. J Immunol 161 (10): 5303–5312, 1998.
10. Salmon JE, Girardi G, Holers VM: Activation of complement mediates antiphospholipid antibody-induced pregnancy loss. Lupus 12 (7): 535–538, 2003.
11. Haj-Yahja S, Sherer Y, Blank M, Kaetsu H, Smolinsky A, Shoenfeld Y: Anti-prothrombin antibodies cause thrombosis in a novel qualitative ex-vivo animal model. Lupus 12 (5): 364–369, 2003.
12. 2-glycoprotein I auto-antibodies. Int Immunol 17 (12): 1533–1542, 2005.
13. Yasuda S, Atsumi T, Matsuura E, Kaihara K, Yamamoto D, Ichikawa K, et al.: Significance of valine/leucine247 polymorphism of beta2-glycoprotein I in antiphospholipid syndrome: Increased reactivity of anti-beta2-glycoprotein I autoantibodies to the valine247 beta2-glycoprotein I variant. Arthritis Rheum 52 (1): 212–218, 2005.
14. Arai T, Yoshida K, Kaburaki J, Inoko H, Ikeda Y, Kawakami Y, et al.: Autoreactive CD4 (+) T-cell clones to beta2-glycoprotein I in patients with antiphospholipid syndrome: Preferential recognition of the major phospholipid-binding site. Blood 98 (6): 1889–1896, 2001.
15. Kuwana M, Matsuura E, Kobayashi K, Okazaki Y, Kaburaki J, Ikeda Y, et al.: Bind-ingofbeta2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells. Blood 105 (4): 1552–1557, 2005.
16. Takeuchi R, Atsumi T, Ieko M, Amasaki Y, Ichikawa K, Koike T.: Suppressed intrinsic ibrinolytic activity by monoclonal anti-beta-2 glycoprotein I autoantibodies: Possible mechanism for thrombosis in patients with antiphospholipid syndrome. Br J Haematol 119 (3): 781–788, 2002.
17. Zhang J., McCrae K. R.: AnnexinA2mediates endothelial cell activation by antiphospholipid/ anti-beta2 glycoprotein I antibodies. Blood 105 (5): 1964–1969, 2005.
18. Raschi E, Testoni C, Bosisio D, Borghi MO, Koike T, Mantovani A, et al.: Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood 101 (9): 3495–3500, 2003.
19. Bohgaki M, Atsumi T, Yamashita Y, Yasuda S, Sakai Y, Furusaki A, et al.: The p38 mitogenactivated protein kinase (MAPK) pathway mediates induction of the tissue factor gene in monocytes stimulated with human monoclonal anti-beta2Glycoprotein I antibodies. Int Immunol 16 (11): 1633–41, 2004.
20. Vega-Ostertag M, Casper K, Swerlick R, Ferrara D, Harris EN, Pierangeli SS.: Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies. Arthritis Rheum 52 (5): 1545–1554, 2005.
21. Lutters BC, Derksen RH, Tekelenburg WL, Lenting PJ, Arnout J, de Groot PG.: Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2’. J Biol Chem 278 (36): 33831–33838, 2003.
22. Pennings MT, M Vanl, Derksen RH, urbanus RT, Romijn RA, Lenting PJ, et al.: Interaction of beta-glycoprotein I with members of the low density lipoprotein receptor family. J Thromb Haemost 4 (8): 1680–1690, 2006.
23. Brandt JT, Triplett DA, Alving B, Scharrer I. Criteria for the diagnosis of lupus anticoagulants: An update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH. Thromb Haemost 74 (4): 1185–1190, 1995.
24. Wisloff F, Jacobsen EM, Liestol S.: Laboratory diagnosis of the antiphospholipid syndrome. Thromb Res 108 (5–6): 263–271, 2002.
25. Yasuda S, Bohgaki M, Atsumi T, Koike T.: Pathogenesis of antiphospholipid antibodies: Impairment of ibrinolysis and monocyte activation via the p38 mitogen-activated protein kinase pathway. Immunobiology 210 (10): 775–780, 2005.