Pulsed drug delivery

Expert Opinion on Drug Delivery

Volumn 3, Issue 4, 2006, Pages 459-462

  De Geest, Bruno G ^a   Mehuys, Els ^a   Laekeman, Gert ^b   Demeester, Jo ^a   De Smedt, Stefaan C ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Drug delivery; Pulsed drug release; Single shot vaccination; Triggered release

Indexed keywords

DRUG DELIVERY SYSTEM; DRUG IMPLANT; EDITORIAL; HUMAN; METHODOLOGY; MICROCAPSULE;

CAPSULES; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; HUMANS;

EID: 39049194378     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425247.3.4.459     Document Type: Review

References (18)

1. STUBBE BG, DE SMEDT SC, DEMEESTER J: "Programmed polymeric devices" for pulsed drug delivery. Pharm. Res. (2004) 21(10):1732-1740. (Pubitemid 39390082)
2. GURNY R, JUGINGER HE: Pulsatile Drug Delivery - Current Applications and Future Trends. NA Peppas (Ed.), Wissenschaftliche Verslagsgesellschaft, Stuttgart, Germany (1993).
3. SANTINI JT, CIMA MJ, LANGER R: A controlled-release microchip. Nature (1999) 397(6717):335-338. • This paper describes the fabrication of implantable microchips containing multiple drug reservoirs. It is possible to programme the microchip in such a way that individual reservoirs can be opened at well-defined time points, thus allowing complicated drug release patterns to be generated on request.
4. GRAYSON AC, CHOI IS, TYLER BM et al.: Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat. Mater. (2003) 2(11):767-772.
5. SKIRTACH AG, DEJUGNAT C, BRAUN D et al.: The role of metal nanoparticles in remote release of encapsulated materials. Nano Letters (2005) 5(7):1371-1377. • This paper describes the fabrication of hollow polyelectrolyte capsules containing gold nanoparticles in their shell. As the gold nanoparticles can absorb laser light, it is possible to remotely activate the capsules inducing the release of encapsulated material.
6. RADT B, SMITH TA, CARUSO F: Optically addressable nanostructured capsules. Adv. Mater. (2004) 16(23-24):2184. (Pubitemid 40072921)
7. DE GEEST BG, DEJUGNAT C, SUKHORUKOV GB et al.: Self-rupturing microcapsules. Adv. Mater. (2005) 17(19):2357-2361. • In this paper, it is shown that the swelling pressure of a degrading microgel can rupture a surrounding membrane, leading to the release of encapsulated material. By tailoring the degradation rate of the microgels, it should in theory be possible to determine the explosion time of the microcapsules.
8. DE GEEST BG, STUBBE BG, JONAS AM et al.: Self-exploding lipid-coated microgels. Biomacromolecules (2006) 7(1):373-379. (Pubitemid 43154516)
9. LYNN DM, LANGER R: Degradable poly(β-amino esters): synthesis, characterization, and self-assembly with plasmid DNA. J. Am. Chem. Soc. (2000) 122(44):10761-10768. (Pubitemid 30944282)
10. LYNN DM, AMIJI MM, LANGER R: pH-responsive polymer microspheres: rapid release of encapsulated material within the range of intracellular pH. Angew. Chem. Int. Ed. Engl. (2001) 40(9):1707-1710. (Pubitemid 32441087)
11. TAMBER H, JOHANSEN P, MERKLE HP, GANDER B: Formulation aspects of biodegradable polymeric microspheres for antigen delivery. Adv. Drug Deliv. Rev. (2005) 57(3):357-376. (Pubitemid 39555502)
12. KVIST PH, BIELECKI M, GERSTENBERG M et al.: Evaluation of subcutaneously-implanted glucose sensors for continuous glucose measurements in hyperglycemic pigs. In Vivo (2006) 20(2):195-203.
13. LEMMER B: Chronopharmacology and controlled drug release. Expert Opin. Drug Deliv. (2005) 2(4):667-681. (Pubitemid 41038679)
14. ORR W: Night-time gastro-oesaphagal reflux disease: prevalence, hazards and management. Eur. J. Gastroenterol. Hepatol. (2005) 17(1):113-120. (Pubitemid 40128935)
15. CROWN A, LIGHTMAN S: Why is the management of glucocorticoid deficiency still controversial: a review of the literature. Clin. Endocrinol. (2005) 63(5):483-492. (Pubitemid 41626741)
16. GIORDANO R, PELLEGRINO M, PICO A et al.: Neurolregulation of the hypothalamus-pituitary-adrenal (HPA) axis in humans: effects of GABA-, mineralocorticoid-, and GH-secretagogue-receptor modulation. ScientificWorldJournal (2006) 6:1-11. (Pubitemid 44440831)
17. DAVID S, MIRICK DK: Circadian disruption, shift work and the risk of cancer: a summary of the evidence and studies in Seattle. Cancer Causes Control (2006) 17(4):539-545.
18. HARRIS CD: Neurophysiology of sleep and wakefulness. Respir. Care Clin. N. Am. (2005) 11(4):567-586. (Pubitemid 41748535)