PAX8 expression in human bladder cancer

Oncology Reports

Volumn 16, Issue 5, 2006, Pages 1015-1020

  Pellizzari, Lucia ^a   Puppin, Cinzia ^b   Mariuzzi, Laura ^a   Saro, Francesca ^a   Pandolfi, Maura ^a   Di Lauro, Roberto ^c   Beltrami, Carlo Alberto ^a   Damante, Giuseppe ^a,b  

^a UNIVERSITY HOSPITAL OF UDINE   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

^c STAZIONE ZOOLOGICA ANTON DOHRN   (Italy)

Author keywords

Bladder cancer; Differential splicing; PAX8

Indexed keywords

CYTOCHROME P450; MESSENGER RNA; MIXED FUNCTION OXIDASE; PAIRED BOX TRANSCRIPTION FACTOR; PAX8 PROTEIN, HUMAN; PHENYLACETATE 2 HYDROXYLASE; PHENYLACETATE 2-HYDROXYLASE;

ALTERNATIVE RNA SPLICING; ARTICLE; BIOSYNTHESIS; BLADDER; BLADDER TUMOR; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ALTERNATIVE SPLICING; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; IMMUNOHISTOCHEMISTRY; MIXED FUNCTION OXYGENASES; PAIRED BOX TRANSCRIPTION FACTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; URINARY BLADDER; URINARY BLADDER NEOPLASMS;

EID: 39049178353     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.16.5.1015     Document Type: Article

References (43)

1. Walther C, Guenet JL, Simon D, Deutsch U, Jostes B, Goulding MD, Plachov D, Balling R and Gruss P: Pax: a murine multigene family of paired box-containing genes. Genomics 11: 424-434, 1991.
2. Strachan T and Read AP: PAX genes. Curr Opin Genet Dev 4: 427-438, 1994. (Pubitemid 24195874)
3. Mansouri A, Hallonet M and Gruss P: PAX genes and their roles in differentiation and development. Curr Opin Cell Biol 8: 851-857, 1994.
4. Maulbecker C and Gruss P: The oncogenetic potential of PAX genes. EMBO J 12: 2361-2367, 1993.
5. Stuart ET: Mammalian PAX genes. Annu Rev Genet 27: 219-236, 1993.
6. Read AP: PAX genes - Paired feet in three camps. Nat Genet 9: 333-334, 1995.
7. Damante G, Tell G and Di Lauro R: A unique combination of transcription factors controls differentiation of thyroid cells. Prog Nucleic Acid Res Mol Biol 66: 307-356, 2001.
8. Plachov D, Chowdhury K, Walther C, Simon D, Guénet JL and Gruss P: PAX 8, a murine paired box gene expressed in the developing escretory system and thyroid gland. Development 110: 643-651, 1990. (Pubitemid 20330539)
9. Poleev A, Fickenscher H, Mundlos S, Winterpacht A and Zabel B: PAX 8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumor. Development 116: 611-662, 1992.
10. Mansouri A, Chowdhury K and Gruss P: Follicular cells of the thyroid gland require PAX 8 gene function. Nat Genet 19: 87-90, 1998. (Pubitemid 28242031)
11. Bouchard M, Souabni A, Mandler M, Neubuser A and Busslinger M: Nephric lineage specification by PAX2 and PAX8: Genes Dev 16: 2958-2970, 2002. (Pubitemid 35334743)
12. Dressler GR and Douglass EC: PAX 2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor. Proc Natl Acad Sci USA 89: 1179-1183, 1992.
13. Eccles MR, Yun K, Reeve AE and Fidler AE: Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors. Am J Pathol 146: 40-45, 1992.
14. Dehbi M and Pelletier J: PAX8-mediated activation of the wt1 tumor suppressor gene. EMBO J 15: 4297-4306, 1996. (Pubitemid 26278712)
15. Dehbi M, Ghahremani M, Lechner M, Dressler G and Pelletier J: The paired-box transcription factor PAX2 positively modulates expression of the Wilms' tumor suppressor gene (WT1). Oncogene 13: 447-453, 1996. (Pubitemid 26283840)
16. Stuart ET, Haffner R, Oren M and Gruss P: Loss of p53 function through PAX-mediated transcriptional repression. EMBO J 14: 5638-5645, 1995.
17. Macchia PE, Lapi P, Krude H, Pirro MT, Missero C, Chiovato L, Souabni A, Baserga M, Tassi V, Pinchera A, Fenzi G, Gruters A, Busslinger M and Di Lauro R: PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis. Nat Genet 19: 83-86, 1995. (Pubitemid 28242030)
18. Fabbro D, Di Loreto C, Beltrami CA, Belfiore A, Di Lauro R and Damante G: Expression of thyroid specific transcription factors TTF-1 and PAX 8 in human thyroid neoplasm. Cancer Res 54: 4744-4749, 1994. (Pubitemid 24276506)
19. Jemal A, Clegg LX, Ward E, Ries LA, Wu X, Jamison PM, Wingo PA, Howe HL, Anderson RN and Edwards BK: Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. Cancer 101: 3-27, 2004. (Pubitemid 38812419)
20. Eble JN, Sauter G, Epstein JI and Sesterhenn IA: Tumours of the urinary system. The World Health Organization Classification of Tumours, Pathology and genetics of Tumours of the urinary system and male genital organs. IARC press, Lyon, pp91-123, 2004.
21. Adshead JM, Kessling AM and Ogden CW: Genetic initiation, progression and prognostic markers in transitional cell carcinoma of the bladder: a summary of the structural and transcriptional changes, and the role of developmental genes. Br J Urol 82: 503-512, 1998. (Pubitemid 28477290)
22. Dyrskjot L, Kruhoffer M, Thykjaer T, Marcussen N, Jensen JL, Moller K and Orntoft TF: Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res 64: 4040-4048, 2004. (Pubitemid 38697320)
23. Sanchez-Carbayo M, Socci ND, Charytonowicz E, Lu M, Prystowsky M, Childs G and Cordon-Cardo C: Molecular profiling of bladder cancer using cDNA microarrays: defining histogenesis and biological phenotypes. Cancer Res 622: 6973-6980, 2002. (Pubitemid 35424089)
24. Fabbro D, Pellizzari L, Mercuri F, Tell G and Damante G: Pax-8 protein levels regulate thyroglobulin gene expression. J Mol Endocrinol 211: 347-354, 1998. (Pubitemid 29005406)
25. Mascia A, Nitsch L, Di Lauro R and Zannini M: Hormonal control of the transcription factor Pax8 and its role in the regulation of thyroglobulin gene expression in thyroid cells. J Endocrinol 172: 163-176, 2002. (Pubitemid 34082955)
26. Chomczynsky P and Sacchi N: Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
27. Kozmik Z, Kurzbauer R, Dorfler P and Busslinger M: Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties. Mol Cell Biol 10: 6024-6035, 1993. (Pubitemid 23292597)
28. Poleev A, Wendler F, Fickenscher H, Zannini MS, Yaginuma K, Abbott C and Plachov D: Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors. Eur J Biochem 228: 899-911, 1995.
29. Fabien N, Fusco A, Santoro M, Barbier Y, Dubois PM and Paulin C: Description of a human papillary thyroid carcinoma cell line. Morphologic study and expression of tumoral markers. Cancer 73: 2206-2212, 1995. (Pubitemid 24107978)
30. Chang JC, Hsieh-Li HM, Jong YJ, Wang NM, Tsai CH and Li H: Treatment of spinal muscular atrophy by sodium butyrate. Proc Natl Acad Sci USA 98: 9808-9813, 2001. (Pubitemid 32769385)
31. Puppin C, D'Aurizio F, D'Elia AV, Cesaratto L, Tell G, Russo D, Filetti S, Ferretti E, Tosi E, Mattei T, Pianta A, Pellizzari L and Damante G: Effects of histone acetylation on sodium iodide symporter promoter and expression of thyroid-specific transcription factors. Endocrinology 146: 3967-3974, 2005. (Pubitemid 41175768)
32. Borson ND, Lacy MQ and Wettstein PJ: Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma. Blood 100: 4629-4639, 2002. (Pubitemid 35429708)
33. Rossi DL, Acebron A and Santisteban P: Function of the homeo and paired domain proteins TTF-1 and Pax-8 in thyroid cell proliferation. J Biol Chem 270: 23139-2342, 1995.
34. Gao J, Huang HY, Pak J, Cheng J, Zhang ZT, Shapiro E, Pellicer A, Sun TT and Wu XR: p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesis. Oncogene 23: 687-696, 2004. (Pubitemid 38241269)
35. Shaw NJ, Georgopoulos NT, Southgate J and Trejdosiewicz LK: Effects of loss of p53 and p16 function on life span and survival of human urothelial cells. Int J Cancer 116: 634-639, 2005. (Pubitemid 41099201)
36. Adshead JM, Ogden CW, Penny MA, Stuart ET and Kessling AM: The expression of PAX 5 in human transitional cell carcinoma of the bladder: relationship with de-differentiation. BJU International 83: 1039-1044, 1999. (Pubitemid 29271876)
37. Muratovska A, Zhou C, He S, Goodyer P and Eccles MR: Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival. Oncogene 22: 7989-7997, 2003. (Pubitemid 37179944)
38. Stuart ET, Kioussi C, Aguzzi A and Gruss P: PAX5 expression correlates with increasing malignancy in human astrocytomas. Clin Cancer Res 1: 207-214, 1995.
39. Babjuk M, Soukup V, Mares J, Duskova J, Sedlacek Z, Trkova M, Pecen L, Dvoracek J, Hanus T, Kocvara R, Novak J and Povysil C: The expression of PAX5, p53 immunohistochemistry and p53 mutation analysis in superficial bladder carcinoma tissue. Correlation with pathological findings and clinical outcome. Int Urol Nephrol 34: 495-501, 1995.
40. Little B: Non-invasive methods of bladder cancer detection. Int Urol Nephrol 35: 331-343, 1995.
41. Dettlaff-Pokora A, Matuszewski M and Schlichtholz B: Telomerase activity in urine sediments as a tool for noninvasive detection of bladder cancer. Cancer Lett 222: 83-88, 2005. (Pubitemid 40544850)
42. Weikert S, Krause H, Wolff I, Christoph F, Schrader M, Emrich T, Miller K and Muller M: Quantitative evaluation of telomerase subunits in urine as biomarkers for noninvasive detection of bladder cancer. Int J Cancer 117: 274-280, 2005. (Pubitemid 41377448)
43. Christoph F, Muller M, Schostak M, Soong R, Tabiti K and Miller K: Quantitative detection of cytokeratin 20 mRNA expression in bladder carcinoma by real-time reverse transcriptase-polymerase chain reaction. Urology 64: 157-161, 2005.