Ethical considerations of fetal therapy

Best Practice and Research in Clinical Obstetrics and Gynaecology

Volumn 22, Issue 1, 2008, Pages 219-231

  Noble, Ray ^a   Rodeck, Charles H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

autonomy; benefits; duties and obligations; ethics; fetal gene therapy; fetal therapy; harms; informed consent; risks

Indexed keywords

BLOOD CLOTTING FACTOR 9;

CLINICAL TRIAL; DISABILITY; FETAL GENE THERAPY; FETAL THERAPY; FETUS; GENE THERAPY; GENE VECTOR; HUMAN; INFORMED CONSENT; INVASIVE PROCEDURE; MEDICAL ETHICS; METHODOLOGY; MORBIDITY; PATIENT COUNSELING; PATIENT DECISION MAKING; PREGNANCY TERMINATION; PREGNANT WOMAN; PRIORITY JOURNAL; PROGENY; RESEARCH ETHICS; REVIEW; RISK ASSESSMENT; RISK BENEFIT ANALYSIS;

ETHICS, CLINICAL; FETAL DISEASES; FETAL THERAPIES; GENE THERAPY; HUMANS; INFORMED CONSENT; PATIENT SELECTION; THERAPEUTIC HUMAN EXPERIMENTATION;

EID: 39049158236     PISSN: 15216934     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpobgyn.2007.07.008     Document Type: Review

References (28)

1. Rodeck C.H., and Deans A. 'Red Cell Alloimmunisation'. In: Rodeck C.H., and Whittle M.J. (Eds). Fetal Medicine: Basic Science and Clinical Practice (1999), Churchill Livingston 785-804
2. Harrison M.R., Keller R.L., Hawgood S.B., et al. A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia. N Engl J Med 349 (2003) 1916-1924
3. American Academy of Pediatrics Committee on Bioethics report. Fetal therapy - ethical considerations. Pediatrics 103 No. 5 (May 1999) 1061-1063
4. Chervenak F.A., and McCullough L.B. Perinatal ethics: a practical method of analysis of obligations to mother and fetus. Obstet Gynecol 66 (1985) 442-446
5. Ruddick W., and Wilcox W. Operating on the fetus. Hastings Cent Rep 12 (1982) 10-14
6. Chervenak F.A., and McCullough L.B. Ethical issues in recommending and offering fetal therapy. In Fetal Medicine. West J Med 159 (1993) 396-399 [Special Issue]
7. Gillon R. Is there a 'new ethics of abortion'?. J Med Ethics 27 Suppl II (2001) ii5-ii9
8. Royal College of Obstetricians and Gynaecologists (RCOG). Law and Ethics in Relation to Court-Authorised Obstetric Intervention. Ethics Committee Guideline no. 1 (2006), RCOG, London
9. Coutelle C., Douar A.-M., College W.H., et al. The challenge of fetal gene therapy. Nat Med 1 (1995) 864-866
10. Department of Health (DH) Gene Therapy Advisory Committee. Report on the Potential Use of Gene Therapy In Utero (1998), DH, London
11. Coutelle C., Themis M., Waddington S.N., et al. Gene therapy progress and prospects: fetal gene therapy - first proofs of concept - some adverse effects. Gene Ther 12 (2005) 1601-1607
12. Bobby Gaspar H., Bjorkegren E., Parsley K., et al. Thrasher Successful Reconstitution of Immunity in ADA-SCID by Stem Cell Gene Therapy Following Cessation of PEG-ADA and Use of Mild Preconditioning. Mol Ther 14 (2006) 505-513
13. Department of Health. Report of the Committee on the Ethics of Gene Therapy. Cm 1788 (1992), DH, London
14. Gene Therapy Advisory Committee. Guidance on Making Proposals to Conduct Gene Therapy Research on Human Subjects (1994), Department of Health, London
15. Foster C. The Ethics of Medical Research on Humans (2001), Cambridge University Press
16. World Medical Association. Declaration of Helisnki: Ethical Principles for Medical Research Involving Human Subjects (1964), Adopted by the 18th WMA General Assembly, Helsinki, Finland
17. Recombinant DNA Advisory Committee. Prenatal Gene Transfer: Scientific, Medical and Ethical Issues. NIH Publication Number: 00-4720 (1999), US Department of Health and Human Services
18. Gene Therapy Advisory Committee. Recommendations of the GTAC/CSM working party on retroviruses (2005). Available (2005). http://www.advisorybodies.doh.gov.uk/genetics/gtac/FinalrecommendationsJune2005.pdf [accessed 25/02/2007]
19. UESCO Report on human gene therapy (1994).
20. Lewis S. Altering the pathway to human gene therapy. Clin Genet 58 (2000) 12-15
21. th. Available (November 2004). http://www.advisorybodies.doh.gov.uk/genetics/gtac/lentiviruses-1104.pdf
22. Woo S.L.C. Policy statement of the American Society of Gene Therapy on reporting of patient adverse effects in gene therapy trials. Mol Ther 1 1 (2000) 7-8
23. Dimichelle D., Miller F.G., and Fins J.J. Gene therapy ethics and haemophilia: an inevitable therapeutic future?. Haemophilia 9 (2003) 145-152
24. Leide J. Human gene therapy: the good, the bad and the ugly. Circ Res 86 (2000) 923-925
25. Rosenberg L.E., and Schechter A.N. Gene therapist, heal thyself. Science 287 (2000) 1751
26. European Society of Gene Therapy (2000). Position paper on social, ethical and public awareness issues in gene therapy.
27. Holtug N. Human gene therapy: down the slippery slope. Bioethics 7 (1993) 402
28. Harris J. Is gene therapy a form of eugenics. Bioethics 7 (1993) 178