Effects of local α2-adrenergic receptor blockade on adipose tissue lipolysis during prolonged systemic adrenaline infusion in normal man

Clinical Physiology and Functional Imaging

Volumn 28, Issue 2, 2008, Pages 125-131

  Simonsen, Lene ^a   Enevoldsen, Lotte H ^b   Stallknecht, Bente ^c   Bülow, Jens ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Abdominal superficial subcutaneous adipose tissue; Blood flow; Gluteal deep subcutaneous adipose tissue; Microdialysis, phentolamine; Preperitoneal adipose tissue

Indexed keywords

ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; GLYCEROL; PHENTOLAMINE; XENON 133; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT;

ABDOMINAL FAT; ADIPOSE TISSUE BLOOD FLOW; ADRENERGIC ACTIVITY; ADRENERGIC RECEPTOR BLOCKING; ADRENERGIC STIMULATION; ADULT; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; LIPOLYSIS; MALE; MICRODIALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; SUBCUTANEOUS FAT; ABDOMINAL SUBCUTANEOUS FAT; BLOOD FLOW; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM;

ADRENERGIC ALPHA-ANTAGONISTS; ADULT; EPINEPHRINE; HUMANS; INFUSIONS, INTRAVENOUS; LIPOLYSIS; MALE; MICRODIALYSIS; PHENTOLAMINE; REGIONAL BLOOD FLOW; SUBCUTANEOUS FAT, ABDOMINAL;

EID: 39049158155     PISSN: 14750961     EISSN: 1475097X     Source Type: Journal    
DOI: 10.1111/j.1475-097X.2007.00781.x     Document Type: Article

References (34)

1. Ardilouze JL, Fielding BA, Currie JM, Frayn KN, Karpe F. Nitric oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans. Circulation (2004); 109: 47-52.
2. Arner P. Differences in lipolysis between human subcutaneous and omental adipose tissues. Ann Med (1995); 27: 435-438.
3. Arner P. Catecholamine-induced lipolysis in obesity. Int J Obes Relat Metab Disord (1999); 23: 10-13.
4. Arner P, Kriegholm E, Engfeldt P, Bolinder J. Adrenergic regulation of lipolysis in situ at rest and during exercise. J Clin Invest (1990); 85: 893-898.
5. Ben-Jonathan N, Porter JC. A sensitive radioenzymatic assay for dopamine, norepinephrine, and epinephrine in plasma and tissue. Endocrinology (1976); 98: 1497-1507.
6. Bülow J, Jelnes R, Astrup A, Madsen JVP. Tissue/blood partition coefficients for xenon in various adipose tissue depots in man. Scand J Clin Lab Invest (1987); 47: 1-3.
7. Bülow J, Simonsen L, Wiggins D, Humphreys SM, Frayn KN, Powell D, Gibbons GF Co-ordination of hepatic and adipose tissue lipid metabolism after oral glucose. J Lipid Res (1999); 40: 2034-2043.
8. Burns TW, Langley PE, Terry BE, Bylund DB, Hoffman BB, Tharp MD, Lefkowitz RJ, Garcia-Sainz JA, Fain JN. Pharmacological characterizations of adrenergic receptors in human adipocytes. J Clin Invest (1981); 67: 467-475.
9. Burns TW, Langley PE, Terry BE, Bylund DB. Studies on desensitization of adrenergic receptors of human adipocytes. Metabolism (1982); 31: 288-293.
10. Carpene C, Galitzky J, Collon P, Esclapez F, Dauzats M, Lafontan M. Desensitization of beta-1 and beta-2, but not beta-3, adrenoceptor-mediated lipolytic responses of adipocytes after long-term norepinephrine infusion. J Pharmacol Exp Ther (1993); 265: 237-247.
11. Enevoldsen L, Simonsen L, Stallknecht B, Galbo H, Bülow J. In vivo human lipolytic activity in preperitoneal and subdivisions of subcutaneous abdominal adipose tissue. Am J Physiol (2001); 281: E1110-E1114.
12. Fain JN, Garcija-Sainz JA. Adrenergic regulation of adipocyte metabolism. J Lipid Res (1983); 24: 945-966.
13. Galitzky J, Lafontan M, Nordenstrom J, Arner P Role of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human adipose tissue. J Clin Invest (1993); 91: 1997-2003.
14. de Glisezinski I, Marion-Latard F, Crampes F, Berlan M, Hejnova J, Cottet-Emard JM, Stich V, Riviere D. Lack of alpha(2)-adrenergic antilipolytic effect during exercise in subcutaneous adipose tissue of trained men. J Appl Physiol (2001); 91: 1760-1765.
15. Guldiken S, Tuncbilek N, Okten OO, Arikan E, Tugrul A. Visceral fat thickness determined using ultrasonography is associated with anthropometric and clinical parameters of metabolic syndrome. Int J Clin Pract (2006); 60: 1576-1581.
16. Hellmer J, Marcus C, Sonnenfeld T, Arner P. Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells. J Clin Endocrinol Metab (1992); 75: 15-20.
17. Hickner RC, Ekelund U, Mellander S, Ungerstedt U, Henriksson J. Muscle blood flow in cats: Comparison of microdialysis ethanol technique with direct measurement. J Appl Physiol (1995); 79: 638-647.
18. Hoffstedt J, Arner P, Hellers G, Lonnqvist F. Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men. J Lipid Res (1997); 38: 795-804.
19. Intaglietta M, Johnson PC In: Principles of Capillary Exchange (ed. Johnson, PC) (1978), pp. 141-166. Wiley, New York.
20. Lafontan M, Berlan M. Fat cell adrenergic receptors and the control of white and brown fat cell function. J Lipid Res (1993); 34: 1057-1091.
21. Marion-Latard F, De GI, Crampes F, Berlan M, Galitzky J, Suljkovicova H, Riviere D, Stich V. A single bout of exercise induces beta-adrenergic desensitization in human adipose tissue. Am J Physiol Regul Integr Comp Physiol (2001); 280: R166-R173.
22. Mauriege P, Galitzky J, Berlan M, Lafontan M. Heterogeneous distribution of beta and alpha-2 adrenoceptor binding sites in human fat cells from various fat deposits: Functional consequences. Eur J Clin Invest (1987); 17: 156-165.
23. Merino-Ibarra E, Artieda M, Cenarro A, Goicoechea J, Calvo L, Guallar A, Civeira F. Ultrasonography for the evaluation of visceral fat and the metabolic syndrome. Metabolism (2005); 54: 1230-1235.
24. Polak J, Moro C, Bessiere D, Hejnova J, Marques MA, Bajzova M, Lafontan M, Crampes F, Berlan M, Stich V Acute exposure to long-chain fatty acids impairs alpha2-adrenergic receptor-mediated antilipolysis in human adipose tissue. J Lipid Res (2007).
25. Ramis JM, Salinas R, Garcia-Sanz JM, Moreiro J, Proenza AM, Llado I. Depot- and gender-related differences in the lipolytic pathway of adipose tissue from severely obese patients. Cell Physiol Biochem (2006); 17: 173-180.
26. Scheller D, Kolb J. The internal reference technique in microdialysis: A practical approach to monitoring dialysis efficiency and to calculating tissue concentration from dialysate samples. J Neurosci Methods (1991); 40: 31-38.
27. Simonsen L, Bülow J, Astrup A, Madsen J, Christensen NJ. Diet-induced changes in subcutaneous adipose tissue blood flow in man: effect of beta-adrenoceptor inhibition. Acta Physiol Scand (1990); 139: 341-346.
28. Simonsen L, Bülow J, Madsen J, Christensen NJ. Thermogenic response to epinephrine in the forearm and abdominal subcutaneous adipose tissue. Am J Physiol (1992); 263: E850-E855.
29. Soyama A, Nishikawa T, Ishizuka T, Ito H, Saito J, Yagi K, Saito Y. Clinical usefulness of the thickness of preperitoneal and subcutaneous fat layer in the abdomen estimated by ultrasonography for diagnosing abdominal obesity in each type of impaired glucose tolerance in man. Endocr J (2005); 52: 229-236.
30. Stallknecht B, Simonsen L, Bülow J, Vinten J, Galbo H. Effect of training on epinephrine-stimulated lipolysis determined by microdialysis in human adipose tissue. Am J Physiol (1995); 269: E1059-E1066.
31. Stallknecht B, Bülow J, Frandsen E, Galbo H. Desensitization of human adipose tissue to adrenaline stimulation studied by microdialysis. J Physiol (1997); 500: 271-282.
32. Stich V, De GI, Crampes F, Suljkovicova H, Galitzky J, Riviere D, Hejnova J, Lafontan M, Berlan M. Activation of antilipolytic alpha(2)-adrenergic receptors by epinephrine during exercise in human adipose tissue. Am J Physiol (1999); 277: R1076-R1083.
33. Stich V, Pelikanova T, Wohl P, Sengenes C, Zakaroff-Girard A, Lafontan M, Berlan M. Activation of alpha2-adrenergic receptors blunts epinephrine-induced lipolysis in subcutaneous adipose tissue during a hyperinsulinemic euglycemic clamp in men. Am J Physiol Endocrinol Metab (2003); 285: E599-E607.
34. Suzuki R, Watanabe S, Hirai Y, Akiyama K, Nishide T, Matsushima Y, Murayama H, Ohshima H, Shinomiya M, Shirai K. Abdominal wall fat index, estimated by ultrasonography, for assessment of the ratio of visceral fat to subcutaneous fat in the abdomen. Am J Med (1993); 95: 309-314.