Lung clearance index in CF: A sensitive marker of lung disease severity

Thorax

Volumn 63, Issue 2, 2008, Pages 96-97

  Davies, Jane C ^a,b,c   Cunningham, Steve ^c,d   Alton, Eric W F W ^a,b,c   Innes, J A ^c,e  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

^c UK Cystic Fibrosis Gene Therapy Consortium ^*  (United Kingdom)

^d Edinburgh Sick Children's Hospital   (United Kingdom)

^e WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSMEMBRANE CONDUCTANCE REGULATOR;

AIRWAY OBSTRUCTION; BRONCHOSCOPY; COMPUTER ASSISTED TOMOGRAPHY; CYSTIC FIBROSIS; DISEASE COURSE; DISEASE MARKER; DISEASE SEVERITY; EDITORIAL; FORCED EXPIRATORY VOLUME; GENE; GENE THERAPY; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; LUNG CLEARANCE; LUNG FUNCTION; PRIORITY JOURNAL; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SPIROMETRY; THORAX RADIOGRAPHY; TRANSMEMBRANE CONDUCTANCE REGULATOR GENE;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CYSTIC FIBROSIS; HUMANS; INFANT; RESPIRATORY FUNCTION TESTS; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX;

EID: 39049138527     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2007.082768     Document Type: Editorial

References (12)

1. Rosenfeld M, Gibson RL, McNamara S, et al. Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis. Pediatr Pulmonol 2001;32:356-66.
2. Nixon GM, Armstrong DS, Carzino R, et al. Early airway infection, inflammation, and lung function in cystic fibrosis. Arch Dis Child 2002;87:306-11.
3. Konstan MW, Morgan WJ, Butler SM, et al. Risk factors for rate of decline in forced expiratory volume in one second in children and adolescents with cystic fibrosis. Scientific Advisory Group and the Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis. J Pediatr 2007;151:134-9.
4. 1 in young adults with cystic fibrosis. Thorax 2006;61:155-7.
5. Gustafsson PM, de Jong PA, Tiddens HAWM, et al. Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis. Thorax 2008;63:129-34.
6. Kraemer R, Blum A, Schibler A, et al. Ventilation inhomogeneities in relation to standard lung function in patients with cystic fibrosis. Am J Respir Crit Care Med 2005;171:371-8.
7. Lum S, Gustafsson P, Ljungberg H, et al. Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests. London Cystic Fibrosis Collaboration. Thorax 2007;62:341-7.
8. Aurora P, Gustafsson P, Bush A, et al. Multiple breath inert gas washout as a measure of ventilation distribution in children with cystic fibrosis. Thorax 2004;59:1068-73.
9. Horsley AR, Gustafsson PM, Macleod K, et al. Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis. Thorax 2008;63:000-0.
10. Kraemer R, Baldwin DN, Ammann RA, et al. Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosis. Respir Res 2006;7:138.
11. Fuchs SI, Buess C, Lum S, et al. Multiple breath washout with a sidestream ultrasonic flow sensor and mass spectrometry: a comparative study. Pediatr Pulmonol 2006;41:1218-25.
12. UK Cystic Fibrosis Gene Therapy Consortium. www.cfgenetherapy.org. uk (accessed 22 November 2007).