An optimization algorithm for designing phase I cancer clinical trials

Contemporary Clinical Trials

Volumn 29, Issue 2, 2008, Pages 102-108

  Jiang, Hui ^a   Liu, Yifan ^b   Su, Zheng ^c  

^a Stanford University   (United States)

^b Krasnow Institute for Advanced Study   (United States)

^c Stony Brook University   (United States)

Author keywords

Clinical trial; Dose escalation; Local search; MTD; Phase I

Indexed keywords

ANTILEUKEMIC AGENT; FLT 3 INHIBITOR; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ALGORITHM; ARTICLE; BAYES THEOREM; CANCER RESEARCH; CLINICAL RESEARCH; CLINICAL TRIAL; DOSE RESPONSE; HUMAN; MEDICAL INFORMATION; PHASE 1 CLINICAL TRIAL; SIMULATION; STATISTICAL MODEL; STOCHASTIC MODEL;

ALGORITHMS; BAYES THEOREM; CHILD; CLINICAL TRIALS, PHASE I AS TOPIC; HUMANS; LEUKEMIA; MAXIMUM TOLERATED DOSE; NEOPLASMS; RESEARCH DESIGN;

EID: 39049127861     PISSN: 15517144     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cct.2007.06.003     Document Type: Article

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