Convenient synthesis of tolcapone, a selective catechol-O-methyltransferase inhibitor

Synthetic Communications

Volumn 38, Issue 5, 2008, Pages 810-815

  Manikumar, Govindarajan ^a   Jin, Chunyang ^a   Rehder, Kenneth S ^a  

^a RTI INTERNATIONAL   (United States)

Author keywords

Catechol O methyltransferase; Nitration; Tolcapone

Indexed keywords

4 BENZYLOXY 3 METHOXYBENZALDEHYDE; BENZALDEHYDE DERIVATIVE; BROMIDE; CATECHOL METHYLTRANSFERASE INHIBITOR; MAGNESIUM; PALLADIUM; PHENOL; TOLCAPONE; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; DEBENZYLATION; DEMETHYLATION; DEPROTECTION REACTION; DRUG SYNTHESIS; GRIGNARD REACTION; LIVER TOXICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPPENAUER OXIDATION; PARKINSON DISEASE; REPRODUCIBILITY;

EID: 39049124087     PISSN: 00397911     EISSN: 15322432     Source Type: Journal    
DOI: 10.1080/00397910701821077     Document Type: Article

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