ANTINEOPLASTIC ACTIVITY;
ARTICLE;
CANCER CELL CULTURE;
CHEMICAL MODIFICATION;
CONTROLLED STUDY;
DRUG CYTOTOXICITY;
DRUG DESIGN;
DRUG POTENCY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
REACTION ANALYSIS;
STRUCTURE ACTIVITY RELATION;
Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay [J]
Zhang HZ, Kasibhatla S, Wang Y, et al. Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay [J]. Bioorg Med Chem, 2004, 12 (2): 309-317.
A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid[J]
Kasibhatia S, Jessen KA, Maliartchouk S, et al. A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid[J]. Proc Natl Acad Sci USA, 2005, 102(34): 12095-12100.
Gambogic acid induces apoptosis and regulates expressions of bax and Bcl-2 protein in human gastric carcinoma MGC-803 Cells [J]
Zhao L, Guo QL, You QD, et al. Gambogic acid induces apoptosis and regulates expressions of bax and Bcl-2 protein in human gastric carcinoma MGC-803 Cells [J]. Biol Pharm Bull, 2004, 27(7): 998-1003.
Repression of telomerase teverse transcriptase mRNA and hTERT promoter by inhibitory effects of oncogene C-myc in gambogic acid treated-human gastric carcinoma cells [J]
Yu J, Guo QL, You QD, et al. Repression of telomerase teverse transcriptase mRNA and hTERT promoter by inhibitory effects of oncogene C-myc in gambogic acid treated-human gastric carcinoma cells [J]. Cancer Chemother Pharmacol, 2006, 58(6): 434-443.
Selective inhibition of a cyclic nucleotide independent protein kinase (G type casein kinase) by quercetin and related polyphenols[J]
Cochet C, Feige JJ, Pirollet F, et al. Selective inhibition of a cyclic nucleotide independent protein kinase (G type casein kinase) by quercetin and related polyphenols[J]. Biochem Pharmacol, 1982, 31(7): 1357-1361.
Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin [J]
Gshwendt W, Horn F, Kittstein W, et al. Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin [J]. Biochem Biophys Res Commun, 1983, 117(2): 444-447.
Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin[J]
Srivastava AK. Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin[J]. Biochem Biophys Res Commun, 1985, 131(1): 1-5.
Determination of the importance of the stereochemistry of psorospermin in topoisomerase II-induced alkylation of DNA and in vitro and in vivo biological activity[J]
Fellows IM, Schwaebe M, Dexheimer TS, et al. Determination of the importance of the stereochemistry of psorospermin in topoisomerase II-induced alkylation of DNA and in vitro and in vivo biological activity[J]. Mol Cancer Ther, 2005, 4 (11): 1729-1739.