Anterior lumbosacral polyradiculopathy after intrathecal administration of methotrexate

Journal of the Neurological Sciences

Volumn 267, Issue 1-2, 2008, Pages 158-161

  Pascual, Ana M ^a   Coret, Francisco ^b   Casanova, Bonaventura ^a   Láinez, Miguel J A ^b  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

Author keywords

Diagnosis; Intrathecal chemotherapy; Intrathecal methotrexate; Myelopathy; Polyradiculopathy; Therapy

Indexed keywords

ASPARAGINASE; CYTARABINE; DAUNORUBICIN; HYDROCORTISONE; METHOTREXATE; PREDNISONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ARTICLE; CASE REPORT; CEREBROSPINAL FLUID EXAMINATION; CLINICAL FEATURE; COMBINATION CHEMOTHERAPY; DIFFERENTIAL DIAGNOSIS; ELECTRODIAGNOSIS; HUMAN; IMMUNOGLOBULIN PRODUCTION; LABORATORY TEST; MALE; MOTOR NERVE CONDUCTION; NUCLEAR MAGNETIC RESONANCE; PHILADELPHIA CHROMOSOME POSITIVE CELL; PHYSICAL EXAMINATION; PLEOCYTOSIS; PRIORITY JOURNAL; PROPHYLAXIS; RADICULOPATHY; SPINAL CORD DISEASE;

ADULT; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DRUG INTERACTIONS; FATAL OUTCOME; HUMANS; HYDROCORTISONE; INJECTIONS, SPINAL; LEG; LUMBOSACRAL PLEXUS; MALE; METHOTREXATE; MOTOR NEURONS; MUSCLE, SKELETAL; NEURAL CONDUCTION; PARALYSIS; PARAPARESIS; POLYRADICULOPATHY; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RESPIRATORY TRACT INFECTIONS; SEPSIS; SPINAL NERVE ROOTS; URINARY BLADDER, NEUROGENIC;

EID: 39049119743     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2007.09.035     Document Type: Article

References (29)

1. Lo Nigro L., Di Cataldo A., and Schiliro G. Acute neurotoxicity in children with B-lineage acute lymphoblastic leukemia (B-ALL) treated with intermediate risk protocols. Med Pediatr Oncol 35 (2000) 449-455
2. McLean D.R., Clink H.M., Ernst P., Coates R., al Kawi M.Z., Bohlega S., et al. Myelopathy after intrathecal chemotherapy. A case report with unique magnetic resonance imaging changes. Cancer 73 (1994) 3037-3040
3. Koh S., Nelson Jr. M.D., Kovanlikaya A., and Chen L.S. Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment. Pediatr Neurol 21 (1999) 576-578
4. Anderson S.C., Baquis G.D., Jackson A., Monteleone O., and Kirkwood J.R. Ventral polyradiculopathy with pediatric acute lymphocytic leukaemia. Muscle Nerve 25 (2002) 106-110
5. Posner J.B. Side effects of chemotherapy. In: Posner J.B. (Ed). Neurologic Complications of Cancer (1995), F.A Davis Company, Philadelphia, PA 282-310
6. Hammack J.E., and Cascino T.L. Chemotherapy and other common drug-induced toxicities of the central nervous system in patients with cancer. In: Vecht C.J. (Ed). Handbook of Clinical Neurology (1998), Elsevier Science, Amsterdam 481-514
7. Philips P.C. Methotrexate toxicity. In: Rottenberg D.A. (Ed). Neurological complications of cancer treatment (1991), Butterworth-Heinemann, Boston 115-134
8. Geiser C.F., Bishop Y., Jaffe N., Furman L., and Traggis D. Adverse effects of intrathecal methotrexate in children with acute leukemia in remission. Blood 45 (1975) 189-195
9. Werner R.A. Paraplegia and quadriplegia after intrathecal chemotherapy. Arch Phys Med Rehabil 69 (1988) 1054-1056
10. Vainionpaa L., Kovala T., Tolonen U., and Lanning M. Chemotherapy for acute lymphoblastic leukemia may cause subtle changes of the spinal cord detectable by somatosensory evoked potentials. Med Pediatr Oncol 28 (1997) 41-47
11. Bay A., Oner A.F., Etlik O., Yilmaz C., and Caksen H. Myelopathy due to intrathecal chemotherapy: report of six cases. J Pediatr Hematol Oncol 27 (2005) 270-272
12. Rao R.D., Swanson J.W., Dejesus R.S., Hunt C.H., and Tefferi A. Methotrexate induced seizures associated with acute reversible magnetic resonance imaging (MRI) changes in a patient with acute lymphoblastic leukemia. Leuk Lymphoma 43 (2002) 1333-133613
13. Henderson R.D., Rajah T., Nicol A.J., and Read S.J. Posterior leukoencephalopathy following intrathecal chemotherapy with MRA-documented vasospasm. Neurology 60 (2003) 326-328
14. Garcia-Tena J., Lopez-Andreu J.A., Ferris J., Menor F., Mulas F., Millet E., et al. Intrathecal chemotherapy-related myeloencephalopathy in a young child with acute lymphoblastic leukemia. Pediatr Hematol Oncol 12 (1995) 377-385
15. Brock S., and Jennings H.R. Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate. Pharmacotherapy 24 (2004) 673-67616
16. Martins da Cunha A.C., Bartsch C.H., and Gadner H. Acute respiratory failure after intrathecal methotrexate administration. Pediatr Hematol Oncol 7 (1990) 189-19217
17. Gorson K.C., Ropper A.H., Muriello M.A., and Blair R. Prospective evaluation of MRI lumbosacral nerve root enhancement in acute Guilain-Barré syndrome. Neurology 47 (1996) 813-817
18. Iwata F., and Utsumi Y. MR imaging in Guillain-Barré syndrome. Pediatr Radiol 27 (1997) 36-38
19. Watterson J., Toogood I., Nieder M., Morse M., Frierdich S., Lee Y., et al. Excessive spinal toxicity from intensive central nervous system-directed therapies. Cancer 74 (1994) 3034-3041
20. Del Colle R., Bassi R., Adami F., Turzzini M., Gioga G., Pea M., et al. Multiple radiculopathy of the lower limbs in a cancer patient with meningeal carcinomatosis. Neurol Sci 21 (2000) 113-115
21. Bleyer W.A., Drake J.C., and Chabner B.A. Neurotoxicity and elevated cerebrospinal fluid methotrexate concentration in meningeal leukemia. N Engl J Med 289 (1973) 770-773
22. Burch P.A., Grossman S.A., and Reinhard C.S. Spinal cord penetration of intrathecally administered cytarabine and methotrexate: a quantitative autoradiographic study. J Natl Cancer Inst 80 (1988) 1211-1216
23. Hahn A.F., Feasby T.E., and Gilbert J.J. Paraparesis following intrathecal chemotherapy. Neurology 33 (1983) 1032-1038
24. Gagliano R.G., and Constanzi J.J. Paraplegia following intrathecal methotrexate. Cancer 37 (1976) 1663-1668
25. Dunkelman H., Earl H.M., and Twelves C. Acute reversible neurological deficit following intrathecal chemotherapy. Cancer Chemother Pharmacol 27 (1991) 329-330
26. Ruggiero A., Conter V., Milani M., Biagi E., Lazzareschi I., Sparano P., et al. Intrathecal chemotherapy with antineoplastic agents in children. Paediatr Drugs 3 (2001) 237-246
27. Mahoney Jr. D.H., Shuster J.J., Nitschke R., Lauer S.J., Steuber C.P., Winick N., et al. Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy-a Pediatric Oncology Group study. J Clin Oncol 16 (1998) 1712-1722
28. Winick N.J., Bowman W.P., Kamen B.A., Roach E.S., Rollins N., Jacaruso D., et al. Unexpected acute neurologic toxicity in the treatment of children with acute lymphoblastic leukemia. J Natl Cancer Inst 84 (1992) 252-256
29. Wolff L., Zighelboim J., and Gale R.P. Paraplegia following intrathecal cytosine arabinoside. Cancer 43 (1979) 83-85