Butterbur root extract and music therapy in the prevention of childhood migraine: An explorative study

European Journal of Pain

Volumn 12, Issue 3, 2008, Pages 301-313

  Oelkers Ax, Rieke ^a   Leins, Anne ^b   Parzer, Peter ^a   Hillecke, Thomas ^c   Bolay, Hans V ^c   Fischer, Jochen ^a   Bender, Stephan ^a   Hermanns, Uta ^a   Resch, Franz ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Viktor Dulger Institute   (Germany)

^c SRH UNIVERSITY HEIDELBERG   (Germany)

Author keywords

Butterbur root extract; Children; Efficacy; Migraine prophylaxis; Music therapy

Indexed keywords

BUTTERBUR ROOT EXTRACT; LIVER ENZYME; PLACEBO; PLANT EXTRACT; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ALLERGIC RHINITIS; ARTHRALGIA; ARTICLE; ASTHMA; BITTER TASTE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG HYPERSENSITIVITY; FATIGUE; FEMALE; FOLLOW UP; GASTROESOPHAGEAL REFLUX; HUMAN; INTERMETHOD COMPARISON; LIMB PAIN; MAJOR CLINICAL STUDY; MALE; MIGRAINE WITH AURA; MIGRAINE WITHOUT AURA; MUSIC THERAPY; NAUSEA; PARALLEL DESIGN; PATIENT COMPLIANCE; PATIENT EDUCATION; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; RASH; SCHOOL CHILD; SIDE EFFECT; SKIN PRURITUS; TREATMENT DURATION; TREATMENT OUTCOME;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHILD; COMBINED MODALITY THERAPY; DOUBLE-BLIND METHOD; FAMILY; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMAGERY (PSYCHOTHERAPY); MALE; MENTAL DISORDERS; MIGRAINE DISORDERS; MUSIC THERAPY; PATIENT COMPLIANCE; PATIENT EDUCATION AS TOPIC; PETASITES; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PROSPECTIVE STUDIES; RELAXATION TECHNIQUES;

EID: 39049118001     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1016/j.ejpain.2007.06.003     Document Type: Article

References (53)

1. Abu-Arafeh I., and Russell G. Prevalence of headache and migraine in schoolchildren. BMJ 309 (1994) 765-769
2. Achenbach T.M. Manual for the Child Behavior Checklist/4-18 and 1991 Profile (1991), Department of Psychiatry, University of Vermont
3. Berk R.A. A primer on robust regression. In: Fox G., and Long J.S. (Eds). Modern methods of data analysis (1990), Sage, Newbury Park 292-324
4. Bille B. A 40-year follow-up of school children with migraine. Cephalalgia 17 (1997) 488-491 [discussion 487]
5. Charlton E. Ethical guidelines for pain research in humans. Committee on Ethical Issues of the International Association for the Study of Pain. Pain 63 (1995) 277-278
6. Costello E.J., Angold A., Burns B.J., Stangl D.K., Tweed D.L., Erkanli A., et al. The Great Smoky Mountains Study of Youth. Goals, design, methods, and the prevalence of DSM-III-R disorders. Arch Gen Psychiat 53 (1996) 1129-1136
7. Damen L., Bruijn J., Coes B.W., Berger M.Y., Passchier J., and Verhagen A.P. Prophylactic treatment of migraine in children. Part 1. A systematic review of non-pharmacological trials. Cephalalgia 26 (2006) 373-383
8. Damen L., Bruijn J., Verhagen A.P., Berger M.Y., Passchier J., and Koes B.W. Prophylactic treatment of migraine in children. Part 2. A systematic review of pharmacological trials. Cephalalgia 26 (2006) 497-505
9. Danesch U., and Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 43 (2003) 76-78
10. Diener H.C., Rahlfs V.W., and Danesch U. The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria. Eur Neurol 51 (2004) 89-97
11. Eccleston C., Morley S., Williams A., Yorke L., and Mastroyannopoulou K. Systematic review of randomised controlled trials of psychological therapy for chronic pain in children and adolescents, with a subset meta-analysis of pain relief. Pain 99 (2002) 157-165
12. Evers S., Pothmann R., Uberall M., Naumann E., and Gerber W.D. Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG) [Therapie idiopathischer Kopfschmerzen im Kindesalter Empfehlungen der Deutschen Migräne- und Kopfschmerzgesellschaft DMKG]. Schmerz 16 (2002) 48-56
13. Fentress D.W., Masek B.J., Mehegan J.E., and Benson H. Biofeedback and relaxation-response training in the treatment of pediatric migraine. Dev Med Child Neurol 28 (1986) 139-146
14. Gold C., Voracek M., and Wigram T. Effects of music therapy for children and adolescents with psychopathology: a meta-analysis. J Child Psychol Psychiat 45 (2004) 1054-1063
15. Grossmann M., and Schmidramsl H. An extract of Petasites hybridus is effective in the prophylaxis of migraine. Int J Clin Pharmacol Therapeut 38 (2000) 430-435
16. Hermann C., Kim M., and Blanchard E.B. Behavioral and prophylactic pharmacological intervention studies of pediatric migraine: an exploratory meta-analysis. Pain 60 (1995) 239-255
17. Hillecke T, Effectivity and theoretical aspects of music therapy in patients with chronic non-malignous pain [Effektivität und theoretische Aspekte von Musiktherapie bei Patienten mit chronischen, nicht-malignen Schmerzen]. Medical Faculty, Heidelberg: Ruprecht-Karls-Universität; 2002.
18. Hillecke T., and Bolay H.V. Music therapy in chronic pain - theoretical basis - the Heidelberg model [Musiktherapie bei chronischen Schmerzen - theoretische Grundlagen - das Heidelberger Modell]. Anasthesiol Intensivmed Notfallmed Schmerzther 35 (2000) 394-400
19. Holden E.W., Deichmann M.M., and Levy J.D. Empirically supported treatments in pediatric psychology: recurrent pediatric headache. J Pediatr Psychol 24 (1999) 91-109
20. Huber P.J. Robust estimation of a location parameter. Ann Math Stat 35 (1964) 73-101
21. IHS. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society. Cephalalgia 8 Suppl. 7 (1988) 1-96
22. Just U., Oelkers R., Bender S., Parzer P., Ebinger F., Weisbrod M., et al. Emotional and behavioural problems in children and adolescents with primary headache. Cephalalgia 23 (2003) 206-213
23. Klassen B.D., and Dooley J.M. Chronic paroxysmal hemicrania-like headaches in a child: response to a headache diary. Headache 40 (2000) 853-855
24. Kovacs M. The Children's Depression, Inventory (CDI). Psychopharmacol Bull 21 (1985) 995-998
25. Labbe E.E. Treatment of childhood migraine with autogenic training and skin temperature biofeedback: a component analysis. Headache 35 (1995) 10-13
26. Laurell K., Larsson B., and Eeg-Olofsson O. Prevalence of headache in Swedish schoolchildren, with a focus on tension-type headache. Cephalalgia 24 (2004) 380-388
27. Lipton R.B., Silberstein S.D., and Stewart W.F. An update on the epidemiology of migraine. Headache 34 (1994) 319-328
28. Lipton R.B., Gobel H., Einhaupl K.M., Wilks K., and Mauskop A. Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology 63 (2004) 2240-2244
29. Lohaus A, Fleer B, Freitag P, Klein - Heßling J. Fragebogen zur Erhebung von Streßerleben und Streßbewältigung im Kindesalter (SSK), Göttingen: Hogrefe; 1996.
30. Lueger R.J. Ein Phasenmodell der Veränderung in der Psychotherapie. Psychotherapeutics 40 (1995) 267-278
31. McGrath P.J., Humphreys P., Goodman J.T., Keene D., Firestone P., Jacob P., et al. Relaxation prophylaxis for childhood migraine: a randomized placebo-controlled trial. Dev Med Child Neurol 30 (1988) 626-631
32. Nickel AK, Effectivity of music therapy in children with migraine [Effektivität von Musiktherapie bei Kindern mit Migräne]. Medical Faculty, Heidelberg: Ruprecht-Karls-Universität; 2004.
33. Nickel A.K., Hillecke T.K., Resch F., and Bolay H.V. Music therapy in the treatment of children with migraine. Mus Ther Today 4 (2003). http://musictherapyworld.net Available from:
34. Olness K., MacDonald J.T., and Uden D.L. Comparison of self-hypnosis and propranolol in the treatment of juvenile classic migraine. Pediatrics 79 (1987) 593-597
35. Pothmann R. Migräne im Kindesalter. Erläuterungen zum Migränetagebuch für Kinder" für die Handhabung in der Praxis (1993), Arcis Verlag, München
36. Pothmann R. Kopfschmerz im Kindesalter (1999), Hippokrate, Stuttgart
37. Pothmann R., and Danesch U. Migraine prevention in children and adolescents: results of an open study with a special butterbur root extract. Headache 45 (2005) 196-203
38. Powers S.W., Patton S.R., Hommel K.A., and Hershey A.D. Quality of life in childhood migraines: clinical impact and comparison to other chronic illnesses. Pediatrics 112 (2003) e1-e5
39. Richter I.L., McGrath P.J., Humphreys P.J., Goodman J.T., Firestone P., and Keene D. Cognitive and relaxation treatment of paediatric migraine. Pain 25 (1986) 195-203
40. Risch M., Scherg H., and Verres R. Music therapy for chronic headaches. Evaluation of music therapeutic groups for patients suffering from chronic headaches [Musiktherapie bei chronischen Kopfschmerzen. Evaluation musiktherapeutischer Gruppen für Kopfschmerzpatienten]. Schmerz 15 (2001) 116-125
41. Rossi L.N., Cortinovis I., Menegazzo L., Brunelli G., Bossi A., and Macchi M. Classification criteria and distinction between migraine and tension- type headache in children. Dev Med Child Neurol 43 (2001) 45-51
42. Sartory G., Muller B., Metsch J., and Pothmann R. A comparison of psychological and pharmacological treatment of pediatric migraine. Behav Res Ther 36 (1998) 1155-1170
43. Scheidegger C., Dahinden C., and Wiesmann U. Effects of extracts and of individual components from Petasites on prostaglandin synthesis in cultured skin fibroblasts and on leucotriene synthesis in isolated human peripheral leucocytes. Pharm Acta Helv 72 (1998) 376-378
44. Silberstein S.D. Preventive treatment of migraine: an overview. Cephalalgia 17 (1997) 67-72
45. Silberstein S.D., and Goadsby P.J. Migraine: preventive treatment. Cephalalgia 22 (2002) 491-512
46. Sillanpaa M., and Anttila P. Increasing prevalence of headache in 7-year-old schoolchildren. Headache 36 (1996) 466-470
47. Sorge F., De Simone R., Marano E., Nolano M., Orefice G., and Carrieri P. Flunarizine in prophylaxis of childhood migraine. A double-blind, placebo-controlled, crossover study. Cephalalgia 8 (1988) 1-6
48. Stiensmeier-Pelster J, Schürmann M, Duda K. Depressions-Inventar für Kinder und Jugendliche. Testzentrale Göttingen, Hogrefe 1989.
49. Tfelt-Hansen P., Block G., Dahlof C., Diener H.C., Ferrari M.D., Goadsby P.J., et al. Guidelines for controlled trials of drugs in migraine: second edition. Cephalalgia 20 (2000) 765-786
50. Unnewehr S., Schneider S., and Margraf J. Kinder-DIPS: diagnostisches Interview bei psychischen Störungen von Kindern und Jugendlichen (1995), Springer, Berlin
51. van der Kuy P.H., and Lohman J.J. A quantification of the placebo response in migraine prophylaxis. Cephalalgia 22 (2002) 265-270
52. Victor S., and Ryan S.W. Drugs for preventing migraine headaches in children. The Cochrane Library (2004) 1-43
53. Winner P., Pearlman E.M., Linder S.L., Jordan D.M., Fisher A.C., and Hulihan J. Topiramate for migraine prevention in children: a randomized, double-blind, placebo-controlled trial. Headache 45 (2005) 1304-1312