Differential effects of long-chain fatty acids and clofibrate on gene expression profiles in cardiomyocytes

Archives of Iranian Medicine

Volumn 11, Issue 1, 2008, Pages 42-49

  Khodadadi, Iraj ^b   Griffin, Bruce ^a   Thumser, Alfred ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cardiomyocyte; Fatty acids; Gene; Microarray

Indexed keywords

CLOFIBRATE; FATTY ACID BINDING PROTEIN; LINOLEIC ACID; LINOLENIC ACID; LIPID; LONG CHAIN FATTY ACID; MESSENGER RNA; MONOUNSATURATED FATTY ACID; OLEIC ACID; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; TRANSCRIPTOME;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; GENE EXPRESSION PROFILING; HEART MUSCLE CELL; LIPID METABOLISM; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; RECEPTOR DENSITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANALYSIS OF VARIANCE; CELLS, CULTURED; CLOFIBRATE; FATTY ACIDS; GENE EXPRESSION REGULATION; MYOCYTES, CARDIAC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

EID: 39049116030     PISSN: 10292977     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Mata LP, Ortega RM. Omega-3 fatty acids in the prevention and control of cardiovascular disease. Eur J Clin Nutr. 2003; 57: S22-S25.
2. Chilton RJ. Pathophysiology of coronary heart disease. Am Osteopath Assoc. 2004; 104: 5-8.
3. Bartlett K, Eaton S. Mitochondrial β-oxidation. Eur J Biochem. 2004; 271: 462-469.
4. Calder PC. Long-chain n-3 fatty acids and cardiovascular disease: further evidence and insights. Nutr Res. 2004; 24: 761-772.
5. Wijendran V, Hayes KC. Dietary n-6 and n-3 fatty acid balance and cardiovascular health. Annu Rev Nutr. 2004; 24: 597-615.
6. Ascherio A. Epidemiologic studies on dietary fats and coronary heart disease. Am J Med. 2002; 113: 9-12.
7. Mori TA, Beilin LJ. Long-chain omega 3 fatty acids, blood lipids and cardiovascular risk reduction. Curr Opin Lipidol. 2001; 12: 11-17.
8. Dyerberg J, Eskesen DC, Andersen PW, Astrup A, Buemann B, Christensen JH, et al. Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study. Eur J Clin Nutr. 2004; 58: 1062-1070.
9. Calder PC. n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci. 2004; 107: 1-11.
10. Sampath H, Ntambi JM. Polyunsaturated fatty acid regulation of gene expression. Nutr Rev. 2004; 62: 333-339.
11. Khan SA, Vanden Heuvel JP. Role of nuclear receptors in the regulation of gene expression by dietary fatty acids. J Nutr Biochem. 2003; 14: 554-567.
12. Clarke SD. Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome. J Nutr. 2001; 131: 1129.
13. Jump DB. Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr Opin Lipidol. 2002; 13: 155-164.
14. Biagi PL, Bordoni A, Lorenzini A, Horrobin DF, Hrelia S. Essential fatty acid metabolism in long-term primary cultures of rat cardiomyocytes: a beneficial effect of n-6/n-3 fatty acids supplementation. Mech Ageing Dev. 1999; 107: 181-195.
15. Gilde AJ, van der Lee KA, Willemsen PH, Chinetti G, van der Leij FR, van der Vusse GJ et al. PPARα and PPARβ/δ, but not PPARγ, modulate the expression of genes involved in cardiac lipid metabolism. Circ Res. 2003; 92: 518-524.
16. Stavinoha MA, Ray-Spellicy JW, Hart-Sailors ML, Mersmann HJ, Bray MS, Young ME. Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids. Am J Physiol. 2004; 287: E878-E887.
17. Cameron-Smith D, Burke LM, Angus DJ, Tunstall RJ, Cox GR, Bonen A et al. A short-term high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle. Am J Clin Nutr. 2003; 77: 313-318.
18. Clavel S, Farout L, Briand M, Briand Y, Jouanel P. Effect of endurance training and/or fish oil supplemented diet on cytoplasmic fatty acid binding protein in rat skeletal muscles and heart. Eur J Appl Physiol. 2002; 87: 193-201.
19. White SM, Constantin PE, Claycomb WC. Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function. Am J Physiol. 2004; 286: H823-H829.
20. Mitcheson JS, Hancox JC, Levi AJ. Cultured adult cardiac myocytes: future applications, culture methods, and morphological and electrophysiological properties. Cardiovasc Res. 1998; 39: 280-300.
21. Habara-Ohkubo A. Differentiation of beating cardiac muscle cells from a derivative of P19 embryonal carcinoma cells. Cell Struct Funct. 1996; 21: 101-110.
22. Ntambi JM, Bene H. Polyunsaturated fatty acid regulation of gene expression. J Mol Neurosci. 2001; 16: 273-278.
23. Jump DB. Fatty acid regulation of gene transcription. Crit Rev Clin Lab Sci. 2004; 41: 41-78.
24. Bolon C, Gauthier C, Simonnet H. Glycolysis inhibition by palmitate in renal cells cultured in a two-chamber system. Am J Physiol. 1997; 273: C1732-C1738.
25. Yu J, Othman MI, Farjo R, Zareparsi S, MacNee SP, Yoshida S et al. Evaluation and optimization of procedures for target labeling and hybridization of cDNA microarrays. Mol Vis. 2002; 8: 130-137.
26. Brown TA. Gene cloning and DNA Analysis: An Introduction. Oxford: Blackwell Science; 2001.
27. Newton CA, Graham A. PCR. Oxford: BIOS Scientific Publishers Ltd; 1997.
28. McPherson MJ, Hames BD, Taylor GR. PCR2: A Practical Approach. New York: Oxford University Press Inc; 1995.
29. Ullmannova V, Haskovec C. The use of housekeeping genes (HKG) as an internal control for the detection of gene expression by quantitative real-time RT-PCR. Folia Biol. 2003; 49: 211-216.
30. Simon R, Radmacher MD, Dobbin K. Design of studies using DNA microarrays. Genet Epidemiol. 2002; 23: 21-36.
31. Churchill GA. Fundamentals of experimental design for cDNA microarrays. Nat Genet. 2002; 32: 490-495.
32. Vinciotti V, Khanin R, D'Alimonte D, Liu X, Cattini N, Hotchkiss G et al. An experimental evaluation of a loop versus a reference design for two-channel microarrays. Bioinformatics. 2005; 21: 492-501.
33. Wit E, McClure J. Statistics for Microarrays: Design, Analysis, and Inference. Chichester, UK: Jone Wiley and Sons Ltd; 2004.
34. Dalgaard P. Introductory Statistics with R. London: Springer; 2002.
35. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004; 3: 1-26.
36. Eisen MB, Spellman PT, Brown PJ, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Nat Acad Sci U S A. 1998; 95: 14863-14868.
37. Reue K. mRNA quantitation techniques: considerations for experimental design and application. J Nutr. 1998; 128: 2038-2044.
38. Bustin SA, Mueller R. Real-time reverse transcription PCR (qRT-PCR) and its potential use in clinical diagnosis. Clin Sci. 2005; 109: 365-379.
39. Bustin SA, Benes V, Nolan T, Pfaffl MW. Quantitative real-time RT-PCR: a perspective. J Mol Endocrinol. 2005; 34: 597-601.
40. Marone M, Mozzetti S, De Ritis D, Pierelli L, Scambia G. Semiquantitative RT-PCR analysis to assess the expression levels of multiple transcripts from the same sample. Biol Proced Online. 2001; 3: 19-25.
41. Chang W, Rickers-Haunerland J, Haunerland NH. Induction of cardiac FABP gene expression by long-chain fatty acids in cultured rat muscle cells. Mol Cell Biochem. 2001; 221: 127-132.
42. Garnier A, Poizat C, Keriel C, Cuchet P, Vork MM, de Jong YF et al. Modulation of fatty acid-binding protein content of adult rat heart in response to chronic changes in plasma lipid levels. Mol Cell Biochem. 1993; 123: 107-112.
43. van Bilsen M, De Vries JE, van der Vusse GJ. Long-term effects of fatty acids on cell viability and gene expression of neonatal cardiac myocytes. Prostaglandins Leukot Essent Fatty Acids. 1997; 57: 39-45.
44. Veerkamp JH, van Moerkerk HT. Fatty acid-binding protein and its relation to fatty acid oxidation. Mol Cell Biochem. 1993; 123: 101-106.
45. Roepstorff C, Helge JW, Vistisen B, Kiens B. Studies of plasma membrane fatty acid-binding protein and other lipid-binding proteins in human skeletal muscle. Proc Nutr Soc. 2004; 63: 239-244.
46. Vidal-Puig A, Jimenez-Linan M, Lowell BB, Hamann A, Hu E, Spiegelman B et al. Regulation of PPARγ gene expression by nutrition and obesity in rodents. J Clin Invest. 1996; 97: 2553-2561.
47. Bonilla S, Redonnet A, Noel-Suberville C, Pallet V, Garcin H, Higueret P. High-fat diets affect the expression of nuclear retinoic acid receptor in rat liver. Br J Nutr. 2000; 83: 665-671.
48. Akbiyik F, Cinar K, Demirpence E, Ozsullu T, Tunca R, Haziroglu R et al. Ligand-induced expression of PPARα and activation of fatty acid oxidation enzymes in fatty liver. Eur J Clin Invest. 2004; 34: 429-435.
49. Groubet R, Pallet V, Delage B, Redonnet A, Higueret P, Cassand P. Hyperlipidic diets induce early alterations of the vitamin A signalling pathway in rat colonic mucosa. Endocr Regul. 2003; 37: 137-144.
50. Delage B, Bairras C, Buaud B, Pallet V, Cassand P. A high-fat diet generates alterations in nuclear receptor expression: prevention by vitamin A and links with cyclooxygenase-2 and β-catenin. Int J Cancer. 2005; 116: 839-846.
51. Ye P, Hu X, Zhao Y. The increase in plasminogen activator inhibitor type-1 expression by stimulation of activators for peroxisome proliferator-activated receptors in human endothelial cells. Chin Med Sci J. 2002; 17: 112-116.
52. Guan JZ, Tamasawa N, Murakami H, Matsui J, Yamato K, Suda T. Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation. Tohoku J Exp Med. 2003; 201: 251-259.
53. Ibabe A, Herrero A, Cajaraville MP. Modulation of peroxisome proliferator-activated receptors (PPARs) by PPARα- and PPARγ-specific ligands and by 17β-estradiol in isolated zebrafish hepatocytes. Toxicol In Vitro. 2005; 19: 725-735.
54. Amsaguine-Safir S, Bianchi A, Collet P, Huin-Schohn C, Jeanvoine A, Becuwe P et al. Induction of the expression of the PPARα by clofibrate in jerboa tissues. Microsc Res Tech. 2003; 61: 185-190.
55. Akbiyik F, Ray DM, Bozkaya H, Demirpence E. Ligand- and species-dependent activation of PPARα. Cell Physiol Biochem. 2004; 14: 269-276.
56. Weatherill AR, Lee JY, Zhao L, Lemay DG, Youn HS, Hwang DH. Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4. J Immunol. 2005; 174: 5390-5397.
57. Lee GY, Kim NH, Zhao ZS, Cha BS, Kim YS. PPARα activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level. Biocheim J., 2004; 378: 983-990.
58. Siculella L, Sabetta S, Damiano F, Giudetti AM, Gnoni GV. Different dietary fatty acids have dissimilar effects on activity and gene expression of mitochondrial tricarboxylate carrier in rat liver. FEBS Lett. 2004; 578: 280-284.
59. Giudetti AM, Sabetta S, di Summa R, Leo M, Damiano F, Siculella L, et al. Differential effects of coconut oil- and fish oil-enriched diets on tricarboxylate carrier in rat liver mitochondria. J Lipid Res. 2003; 44: 2135-2141.
60. Gilde AJ, van Bilsen M. Peroxisome proliferator-activated receptors (PPARs): regulators of gene expression in heart and skeletal muscle. Acta Physiol Scand. 2003; 178: 425-434.
61. 2 is a ligand for the adipocyte determination factor PPARγ. Cell. 1995; 83: 803-812.