Serum concentration of interleukin-18 is up-regulated in patients with ANCA-associated vasculitis

Autoimmunity

Volumn 40, Issue 7, 2007, Pages 529-531

  Hultgren, O ^a   Andersson, B ^a   Hahn Zoric, M ^a   Almroth, G ^b  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

ANCA; Interleukin 18; Vasculitis; Wegener's granulomatosis

Indexed keywords

AUTOANTIBODY; INTERLEUKIN 18; MYELOBLASTIN; MYELOPEROXIDASE;

ADULT; AGED; ANCA ASSOCIATED VASCULITIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HEMODIALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; UPREGULATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; AUTOIMMUNE DISEASES; HUMANS; INFLAMMATION; INTERLEUKIN-18; MALE; MIDDLE AGED; MYELOBLASTIN; PEROXIDASE; RENAL DIALYSIS; VASCULITIS;

EID: 39049109175     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930701622783     Document Type: Article

References (10)

1. Hattar, K., van Burck, S., Bickenbach, A., Grundel, U., Maus, U. and Lohmeyer, J. (2005) Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation. J Leukoc Biol, 78, pp. 992-1000.
2. Kobold, AC Muller, Kallenberg, CG and Tervaert, JW (1999) Monocyte activation in patients with Wegener's granulomatosis. Ann Rheum Dis, pp. 237-245.
3. Ohlsson, S., Wieslander, J. and Segelmark, M. (2004) Circulating cytokine profile in anti-neutrophilic cytoplasmatic autoantibody-associated vasculitis: Prediction of outcome. Mediators Inflamm, 13, pp. 275-283.
4. Ludviksson, BR, Sneller, MC, Chua, KS, Talar-Williams, C., Langford, CA and Ehrhardt, RO (1998) Active Wegener's granulomatosis is associated with HLA-DR+CD4+T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: Reversal with IL-10. J Immunol, 160, pp. 3602-3609.
5. Wong, CK, Ho, CY, Li, EK, Tam, LS and Lam, CW (2002) Elevated production of interleukin-18 is associated with renal disease in patients with systemic lupus erythematosus. Clin Exp Immunol, 130, pp. 345-351.
6. Jennette, JC, Falk, RJ, Andrassy, K., Bacon, PA, Churg, J. and Gross, WL (1994) Nomenclature of systemic vasculitides; proposal of an international concensus conference. Arthritis Rheum, 37, pp. 187-192.
7. Eriksson, P. (2005) Nine patients with anti-neutrophil cytoplasmic antibody-positive vasculitis successfully treated with rituximab. J Int Med, 257, pp. 540-548.
8. Chiang, CK, Huang, JW, Hsu, SP, Ho, Ti, Pai, MF and Peng, YS (2006) Plasma interleukin-18 levels in hemodialysis patients: Increased by dialysis process and association with interleukin-6 and tumor necrosis factor-alpha. Blood Purif, 24, pp. 174-179.
9. Yao, Q., Pecoits-Filho, R., Lindholm, B. and Stenvinkel, P. (2004) Traditional and non-traditional risk factors as contributors to atherosclerotic cardiovascular disease in end-stage renal disease. Scand J Urol Nephrol, 38:5, pp. 405-416.
10. Hewins, P., Morgan, MD, Holden, N., Neil, D., Williams, JM and Savage, CO (2006) IL-18 is upregulated in the kidney and primes neutrophil responsiveness in ANCA-associated vasculitis. Kidney Int, 69, pp. 605-619.