Expression of COX-1, COX-2, and PPAR-γ in the gastric mucosa of children with Helicobacter pylori infection

Pediatrics International

Volumn 50, Issue 1, 2008, Pages 1-6

  Haruna, Hidenori ^a   Shimizu, Toshiaki ^a   Ohtsuka, Yoshikazu ^a   Yarita, Yukiko ^a   Fujii, Tohru ^a   Kudo, Takahiro ^a   Yamashiro, Yuichiro ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

COX; Gastric mucosa; Helicobacter pylori; mRNA expression; PPAR

Indexed keywords

BETA ACTIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADOLESCENT; ANEMIA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROTECTION; CLINICAL ARTICLE; DUODENITIS; ENDOSCOPY; FEMALE; GASTRITIS; GASTROINTESTINAL SYMPTOM; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; INFLAMMATION; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; STOMACH MUCOSA; UREA BREATH TEST;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FEMALE; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; INFANT; MALE; PPAR GAMMA; RNA, MESSENGER;

EID: 39049107541     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/j.1442-200X.2007.02504.x     Document Type: Article

References (26)

1. Drumm B. Helicobacter pylori and the pediatric patient. Gastroenterol. Clin. North Am. 1993 22 : 169 82.
2. Ernst PB, Gold BD, Benjamin D. Helicobacter pylori in childhood: New insights into the immunopathogenesis of gastric disease and implications for managing infection in children. J. Pediatr. Gastroenterol. Nutr. 1999 28 : 462 73.
3. Zevering Y, Jacob L, Meyer TF. Naturally acquired human immune responses against Helicobacter pylori and implications for vaccine development. Gut 1999 45 : 465 74.
4. Parrello T, Luzza F, Sebkova L et al. Expression of pro-inflammatory and Th1 but not Th2 cytokines is enhanced in gastric mucosa of Helicobacter pylori-infected children. Gut 2000 47 (Suppl. 1 A33.
5. Shimizu T, Haruna H, Ohtsuka Y, Kaneko K, Gupta R, Yamashiro Y. Cytokines in the gastric mucosa of children with Helicobacter pylori infection. Acta Paediatr. 2004 93 : 322 6.
6. Robert A, Nezamis JE., Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats. Prevention of necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 1979 77 : 433 43.
7. Tarnawski A, Brzozowski T, Sarfeh IJ et al. Prostaglandin protection of human isolated gastric glands against indomethacin and ethanol injury. J. Clin. Invest. 1988 81 : 1081 9.
8. Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J. 1991 5 : 2304 12.
9. Hla T, Neilson K. Human cyclooxygenase-2 DNA. Proc. Natl Acad. Sci. USA 1992 89 : 7384 8.
10. Tatsuguchi A, Sakamoto C, Wada K et al. Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans. Gut 2000 46 : 782 9.
11. Jackson LM, Wu KC, Mahida YR, Jenkins D, Hawkey CJ. Cyclooxygenase (COX) 1 and 2 in normal, inflamed, and ulcerated human gastric mucosa. Gut 2000 47 : 762 70.
12. Takahashi S, Shigeta J, Inoue H, Tanabe T, Okabe S. Localization of cyclooxygenase-2 and regulation of its mRNA expression in gastric ulcers in rats. Am. J. Physiol. 1998 275 : 1137 45.
13. Konturek PC, Konturek SJ, Kania J et al. Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin contents and expression of PPARγ and apoptosis-related proteins in gastric cancer patients. Dig. Dis. Sci. 2003 48 : 2005 17.
14. Li MY, Deng H, Zhao JM, Dai D, Tan XY. PPARγ pathway activation results in apoptosis and COX-2 inhibition in HepG2 cells. World J. Gastroenterol. 2003 9 : 1220 26.
15. Wilson TM, Brown PJ, Sternbach DD, Henke BR. The PPARs: From orphan receptors to drug discovery. J. Med. Chem. 2000 43 : 527 50.
16. Fajas L, Auboeuf D, Raspe E et al. The organization, promoter analysis, and expression of the human PPARγ gene. J. Biol. Chem. 1997 272 : 18 779 89.
17. Escher P, Wahli W. Peroxisome proliferators-activated receptors: Insight into multiple cellular functions. Mutat. Res. 2000 448 : 121 38.
18. Kersten S, Desvergne B, Wahli W. Roles of PPARs in health and disease. Nature 2000 405 : 421 4.
19. Dubuquoy L, Dharancy S, Nutten S, Pettersson S, Auwerx J, Desreumaux P. Role of peroxisome proliferators-activated receptor γ and retinoid X receptor heterodimer in hepatogastroenterological diseases. Lancet 2002 360 : 1410 18.
20. Gupta RA, Polk DB, Krishna U et al. Activation of peroxisome proliferators-activated receptor γ suppresses nuclear factor κB-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J. Biol. Chem. 2001 276 : 31 059 66.
21. Takahashi N, Okumura T, Motomura W, Fujimoto Y, Kawabata I, Kohgo Y. Activation of PPARγ inhibits cell growth and induces apoptosis in human gastric cancer cells. FEBS Lett. 1999 455 : 135 9.
22. Kim KM, Oh YL, Ko JS, Choe YH, Seo JK. Histopathology and expression of Ki-67 and cyclooxygenase-2 in childhood Helicobacter pylori gastritis. J. Gastroenterol. 2004 39 : 231 7.
23. Mizuno H, Sakamoto C, Matsuda K et al. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 1997 112 : 387 97.
24. Konturek PC, Kania J, Konturek JW, Nikiforuk A, Konturek SJ, Hahn EG. H. pylori infection, atrophic gastritis, cytokines, gastrin, COX-2, PPARγ and impaired apoptosis in gastric carcinogenesis. Med. Sci. Monit. 2003 9 : SR65 78.
25. Konturek PC, Kania J, Kukharsky V et al. Implication of peroxisome proliferator-activated receptor γ and proinflammatory cytokines in gastric carcinogenesis: Link to Helicobacter pylori-infection. J. Pharmacol. Sci. 2004 96 : 134 43.
26. Inoue H, Tanabe T, Umesono K. Feedback control of cyclooxygenase-2 expression through PPARγ. J. Biol. Chem. 2000 275 : 28 028 32.