Fetal anaemia: diagnosis and management

Best Practice and Research in Clinical Obstetrics and Gynaecology

Volumn 22, Issue 1, 2008, Pages 15-29

  Brennand, Janet ^a   Cameron, Alan ^a  

^a QUEEN MOTHER S HOSPITAL   (United Kingdom)

Author keywords

fetal anaemia; intrauterine transfusion; kell; middle cerebral artery Doppler; parvovirus; rhesus disease

Indexed keywords

MATERNAL ANTIBODY;

ALLOIMMUNIZATION; AMNIOCENTESIS; ANEMIA; BLOOD GROUP KELL SYSTEM; BLOOD GROUP RHESUS SYSTEM; DOPPLER ECHOGRAPHY; FETUS BLOOD SAMPLING; FETUS DISEASE; FETUS HYDROPS; FETUS MONITORING; HIGH RISK PREGNANCY; HUMAN; INTRAUTERINE BLOOD TRANSFUSION; MIDDLE CEREBRAL ARTERY; NON INVASIVE PROCEDURE; PARVOVIRUS INFECTION; PRIORITY JOURNAL; REVIEW;

ANEMIA; BLOOD TRANSFUSION, INTRAUTERINE; FEMALE; FETAL DISEASES; HUMANS; KELL BLOOD-GROUP SYSTEM; MIDDLE CEREBRAL ARTERY; PARVOVIRIDAE INFECTIONS; PARVOVIRUS B19, HUMAN; PREGNANCY; PRENATAL DIAGNOSIS; RH ISOIMMUNIZATION; ULTRASONOGRAPHY, PRENATAL;

EID: 39049101370     PISSN: 15216934     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpobgyn.2007.08.005     Document Type: Review

References (90)

1. Moise Jr. K.J. Red blood cell alloimmunization in pregnancy. Semin Hematol 42 (2005) 169-178
2. Van Kamp I.L., Klumper F.J.C.M., Oepkes D., et al. Complications of intrauterine intravascular transfusion for fetal anemia due to maternal red-cell alloimmunization. Am J Obstet Gynecol 192 (2005) 171-177
3. MacKenzie I.Z., Bowell P., Gregory H., et al. Routine antenatal rhesus D immunoglobulin prophylaxis: the results of a prospective 10 year study. Br J Obstet Gynaecol 106 (1999) 492-497
4. Urbaniak S.J. The scientific basis of antenatal prophylaxis. Br J Obstet Gynaecol 105 (1998) 11-18
5. Crowther C.A., and Keirse M.J. Anti-D administration in pregnancy for preventing rhesus alloimmunisation. Cochrane Database Syst Rev 2 (2000) CD000020
6. National Institute for Clinical Excellence Technology Appraisal No. 41. Guidance on the use of routine antenatal anti-D prophylaxis for RhD-negative women. NICE; 2002.
7. Bennett P.R., Le Van Kim C., Colin Y., et al. Prenatal determination of fetal RhD type by DNA amplification. N Engl J Med 329 (1993) 607-610
8. Lo Y.M.D., Corbetta N., Chamberlain P.F., et al. Presence of fetal DNA in maternal plasma and serum. Lancet 350 (1997) 485-487
9. Daniels G., Finning K., and Martin P. Soothill. Fetal blood group genotyping from DNA from maternal plasma: an important advance in the management and prevention of haemolytic disease of the fetus and newborn. Vox Sang 87 (2004) 225-232
10. Moise Jr. K.J., and Scumacher B. Anaemia. In: Fisk N.M., and Moise Jr. K.J. (Eds). Fetal therapy. 1st edn. (1997), University Press, Cambridge 141-163
11. Gooch A, Parker J, Wray J, et al., Guideline for blood grouping and antibody testing in pregnancy. London: British Committee for Standards in Haematology (BCSH), 2006.
12. Nicolaides K.H., and Rodeck C.H. Maternal serum anti-D antibody concentration and assessment of rhesus isoimmunisation. BMJ 304 (1992) 1155-1156
13. Liley A.W. Liquor amnii analysis in the management of pregnancy complicated by rhesus sensitization. Am J Obstet Gynecol 82 (1961) 1359-1370
14. Nicolaides K.H., Rodeck C.H., Mibasham R.S., et al. Have Liley charts outlived their usefulness?. Am J Obstet Gynecol 155 (1986) 90-94
15. Queenan J.T., Tomai T.P., Ural S.H., et al. Deviation in amniotic fluid optical density at a wavelength of 450nm in Rh-immunized pregnancies from 14 to 40 weeks' gestation: a proposal for clinical management. Am J Obstet Gynecol 168 (1993) 1370-1376
16. Spinnato J.A., Clark A.L., Ralston K.K., et al. Hemolytic disease of the fetus: a comparison of the Queenan and extended Liley methods. Obstet Gynecol 92 (1998) 441-445
17. Scott F., and Chan F.Y. Assessment of the clinical usefulness of the 'Queenan' chart versus the 'Liley' chart in predicting severity of rhesus iso-immunization. Prenat Diagn 18 (1998) 1143-1148
18. Whitfield C.R., Neely R.A., and Telford M.E. Amniotic fluid analysis in rhesus isoimmunisation. J Obstet Gynaecol Br Commonw 75 (1968) 121-127
19. Bowman J.M. The management of Rh-isoimmunization. Obstet Gynecol 52 (1978) 1-16
20. Tabor A., Philip J., Madsen M., et al. Randomised controlled trial of genetic amniocentesis in 4606 low-risk women. Lancet 1 8493 (1986) 1287-1293
21. Bowman J.M., and Pollock J.M. Transplacental fetal hemorrhage after amniocentesis. Obstet Gynecol 66 (1985) 749-754
22. Tabor A., Bang J., and Norgaard-Pedersen B. Feto-maternal haemorrhage with genetic amniocentesis: results of a randomized trial. Br J Obstet Gynaecol 94 (1987) 528-534
23. Moise K.J. Management of rhesus alloimmunization in pregnancy. Obstet Gynecol 100 (2002) 600-611
24. Whitecar P.W., and Moise Jr. K.J. Sonographic methods to detect fetal anemia in red blood cell alloimmunization. Obstet Gynecol Surv 55 (2000) 240-250
25. Vintzileos A.M., Campbell W.A., Storlazzi E., et al. Fetal liver ultrasound measurements in isoimmunized pregnancies. Obstet Gynecol 68 (1986) 162-167
26. Roberts A.B., Mitchell J.M., and Pattison N.S. Fetal liver length in normal and isoimmunized pregnancies. Am J Obstet Gynecol 161 (1989) 42-46
27. Oepkes D., Meerman R.H., Vandenbussche F.P., Van Kamp I.L., et al. Ultrasonographic fetal spleen measurements in red blood cell-allimmunized pregnancies. Am J Obstet Gynecol 169 (1983) 121-128
28. Bahado-Singh R., Oz U., Mari G., et al. Fetal splenic size in anemia due to Rh-allimmunization. Obstet Gynecol 92 (1998) 828-832
29. Oepkes D. Invasive versus non-invasive testing in red-cell alloimmunized pregnancies. Eur J Obstet Gynecol Reprod Biol 92 (2000) 83-89
30. Dukler D., Oepkes D., Seaward G., et al. Noninvasive tests to predict fetal anemia: a study comparing Doppler and ultrasound parameters. Am J Obstet Gynecol 188 (2003) 1310-1314
31. Fan F.C., Chen R.Y.Z., Schuessler G.B., et al. Effects of hematocrit variations on regional hemodynamics and oxygen transport in the dog. Am J Physiol 238 (1984) H545-H552
32. Fumia F.D., Edelstone D.I., and Holzman I.R. Blood flow and oxygen delivery to fetal organs as functions of fetal hematocrit. Am J Obstet Gynecol 150 (1984) 274-282
33. Giles W.B., and Trudinger B.J. Umbilical cord whole blood viscosity and the umbilical artery flow velocity time waveforms: a correlation. Br J Obstet Gynaecol 93 (1986) 466-470
34. Gill R.W. Measurement of blood flow by ultrasound: accuracy and sources of error. Ultrasound Med Biol 11 (1985) 625-640
35. Mari G., Andrignolo A., Abuhamad A.Z., et al. Diagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization. Ultrasound Obstet Gynecol 5 (1995) 400-405
36. Mari G., Deter R.L., Carpenter R.L., et al. Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative group for Doppler assessment of the blood velocity in anemic fetuses. N Engl J Med 342 (2000) 9-14
37. Mari G. Middle cerebral artery peak systolic velocity for the diagnosis of fetal anemia: the untold story. Ultrasound Obstet Gynecol 25 (2005) 323-330
38. Nicolaides K.H., Fontanarosa M., Gabbe S.G., et al. Failure of ultrasonographic parameters to predict the severity of fetal anemia in rhesus isoimmunization. Am J Obstet Gynecol 158 (1988) 920-926
39. Copel J.A., Grannum P.A., Green J.J., et al. Pulsed Doppler flow-velocity waveforms in the prediction of fetal hematocrit of the severely isoimmunized pregnancy. Am J Obstet Gynecol 161 (1989) 341-344
40. Mari G., Detti L., Oz U., et al. Accurate prediction of fetal hemoglobin by dopper ultrasonography. Obstet Gynecol 99 (2002) 589-593
41. Detti L., Mari G., Akiyama M., et al. Longitudinal assessment of the middle cerebral artery peak systolic velocity in healthy fetuses and in fetuses at risk for anemia. Am J Obstet Gynecol 187 (2002) 937-939
42. Nicolaides K.H., Soothill P.W., Rodeck C.H., et al. Rh Disease: intravascular fetal blood transfusion by cordocentesis. Fetal Ther 1 (1986) 185-192
43. Welch R., Rampling M.W., Anwar A., et al. Changes in hemorheology with fetal intravascular transfusion. Am J Obstet Gynecol 170 (1994) 726-732
44. El Bouhmadi A., Boulot P., Laffargue F., et al. Rheological properties of fetal red cells with special reference to aggregability and disaggregability analyzed by light transmission and laser backscattering techniques. Clin Hemorheol Microcirc 22 (2000) 79-90
45. Mari G., Rahman F., Olofsson P., et al. Increase of fetal hematocrit decreases the middle cerebral artery peak systolic velocity in pregnancies complicated by rhesus alloimmunization. J Matern Fetal Med 6 (1997) 206-208
46. Detti L., Oz U., Guney I., et al. Doppler ultrasound velocimetry for timing the second intrauterine transfusion in fetuses with anemia from red cell alloimmunization. Am J Obstet Gynecol 185 (2001) 1048-1051
47. Deren O., and Onderoglu L. The value of middle cerebral artery systolic velocity for initial and subsequent management in fetal anemia. Eur J Obstet Gynecol Reprod Biol 101 (2002) 26-30
48. Scheier M., Hernandez-Andrade E., Fonseca E.B., et al. Prediction of severe fetal anemia in red blood cell allimmunization after previous intrauterine transfusions. Am J Obstet Gynecol 195 (2006) 1550-1556
49. Mari G., Zimmermann R., Moise K.J., et al. Correlation between middle cerebral artery peak systolic velocity and fetal hemoglobin after 2 previous intrauterine transfusions. Am J Obstet Gynecol 193 (2005) 1117-1120
50. Delle Chiaie L., Buck G., Grab D., et al. Prediction of fetal anemia with doppler measurement of the middle cerebral artery peak systolic velocity in pregnancies complicated by maternal blood group alloimmunization or parvovirus B19 infection. Ultrasound Obstet Gynecol 18 (2001) 232-236
51. Cosmi E., Mari G., Delle Chiaie L., et al. Noninvasive diagnosis by doppler ultrasonography of fetal anemia resulting from parvovirus infection. Am J Obstet Gynecol 187 (2002) 1290-1293
52. Van Dongen H., Klumper F.J.C.M., Sikkel E., et al. Non-invasive tests to predict fetal anemia in Kell-alloimmunized pregnancies. Ultrasound Obstet Gynecol 25 (2005) 341-345
53. Sueters M., Arabin B., and Oepkes D. Doppler sonography for predicting fetal anemia caused by massive fetomaternal hemorrhage. Ultrasound Obstet Gynecol 22 (2003) 186-189
54. Senat M.V., Loizeau S., Couderc S., et al. The value of middle cerebral artery peak systolic velocity in the diagnosis of fetal anemia after intrauterine death of one monochorionic twin. Am J Obstet Gynecol 189 (2003) 1320-1324
55. Haak M.C., Oosterhof H., Mouw R.J., et al. Pathophysiology and treatment of fetal anemia due to placental chorioangioma. Ultrasound Obstet Gynecol 14 (1999) 68-70
56. Leung W.C., Oepkes D., Seaward G., et al. Serial sonographic findings of four fetuses with homozygous alpha-thalassemia-1 From 21 weeks onwards. Ultrasound Obstet Gynecol 19 (2002) 56-59
57. Oepkes D., Seaward G., Vandenbussche F.P.H.A., et al. Doppler ultrasonography versus amniocentesis to predict fetal anemia. N Engl J Med 355 (2006) 156-164
58. Liley A.W. Intrauterine transfusion of foetus in haemolytic disease. BMJ 2 (1963) 1107-1109
59. Fox C, Martin W, Somerset DA, et al. Early intraperitoneal transfusion and adjuvant maternal immunoglobulin therapy in the treatment of severe red cell alloimmunisation, prior to fetal intravascular transfusion. Fetal Ther, in press.
60. Cooperberg P.L., and Carpenter C.W. Ultrasound as an aid in intrauterine transfusion. Am J Obstet Gynecol 128 (1977) 239-241
61. Rodeck C.H., Kemp J.R., Holman C.A., et al. Direct intravascular fetal blood transfusion by fetoscopy in severe rhesus isoimmunisation. Lancet i (1981) 625-627
62. Westgren M., Selbing A., and Stangenberg M. Fetal intracardiac transfusions in patients with severe rhesus isoimmunisation. BMJ 296 (1988) 885-886
63. Schumacher B., and Moise K.J. Fetal transfusion for red blood cell alloimmunization in pregnancy. Obstet Gynecol 88 (1996) 137-150
64. MacGregor S.N., Socol M.L., Pielet B.W., et al. Prediction of hematocrit decline after intravascular transfusion. Am J Obstet Gynecol 161 (1989) 1491-1493
65. Jones H.M., Lynch D.C., Nicolaides K., et al. Survival of transfused adult cells in the fetus. Fetal Ther 1 (1986) 193-195
66. Weiner C.P., Wenstrom K.D., Sipes S.L., et al. Risk factors for cordocentesis and fetal intravascular transfusion. Am J Obstet Gynecol 165 (1991) 1020-1025
67. Poissonnier M.H., Brossard Y., Demedeiros N., et al. Two hundred intrauterine exchange transfusions in severe blood incompatibilities. Am J Obstet Gynecol 161 (1989) 709-713
68. Somerset D.A., Moore A., Whittle M.J., et al. An audit of outcome in intravascular transfusions using the intrahepatic portion of the fetal umbilical vein compared to cordocentesis. Fetal Diagn Ther 21 (2006) 272-276
69. Van Kamp I.L., Klumper F.C.J.M., Bakkum R.S.L.A., et al. The severity of immune fetal hydrops is predictive of fetal outcome after intrauterine treatment. Am J Obstet Gynecol 185 (2001) 668-673
70. Binks A.S., Lind T., and McNay R.A. Effects of rhesus haemolytic disease upon birthweight. J Obstet Gynaecol Br Commonw 80 (1973) 301-304
71. Roberts A., Grannum P., Belanger K., et al. Fetal growth and birthweight in isoimmunized pregnancies after intravenous intrauterine transfusion. Fetal Diagn Ther 8 (1993) 407-411
72. Janssens H.M., de Haan M.J., van Kamp I.L., et al. Outcome for children treated with fetal intravascular transfusions because of severe blood group antagonism. J Pediatr 131 (1997) 373-380
73. Hudon L., Moise Jr. K.J., Hegemier S.E., et al. Long-term neurodevelopmental outcome after intrauterine transfusion for the treatment of fetal hemolytic disease. Am J Obstet Gynecol 179 (1998) 858-863
74. Caine M.E., and Mueller-Heubach E. Kell sensitzation in pregnancy. Am J Obstet Gynecol 154 (1986) 85-90
75. Leggat H.M., Gibson J.M., Barron S.L., et al. Anti-Kell in pregnancy. Br J Obstet Gynaecol 98 (1991) 162-165
76. Vaughan J.I., Manning M., Warwick R.M., et al. Inhibition of erythroid progenitor cells by anti-kell antibodies in fetal alloimmune anemia. N Engl J Med 338 (1998) 798-803
77. Weiner C.P., and Widness J.A. Decreased fetal erythropoiesis and hemolysis in Kell haemolytic anemia. Am J Obstet Gynecol 174 (1996) 547-551
78. Weinstein L. Irregular antibodies causing haemolytic disease of the newborn. Obstet Gynecol Surv 31 (1976) 581-591
79. Bowman J.M., Pollock J.M., Manning F.A., et al. Maternal Kell blood group alloimmunization. Obstet Gynecol 79 (1992) 239-244
80. McKenna D.S., Nagaraja H.N., and O'Shaughnessy R. Management of pregnancies complicated by anti-Kell isoimmunization. Obstet Gynecol 93 (1999) 667-673
81. Grant S.R., Kilby M.D., Meer L., et al. The outcome of pregnancy in Kell alloimmunisation. Br J Obstet Gynaecol 107 (2000) 481-485
82. Wenk R.E., Goldstein P., and Felix J.K. Kell alloimmunization, hemolytic disease of the newborn, and perinatal management. Obstet Gynecol 66 (1985) 473-476
83. De Jong E.P., de Haan T.R., Kroes A.C.M., et al. Parvovirus B19 infection in pregnancy. J Clin Virol 36 (2006) 1-7
84. Heegaard E.D., and Brown K.E. Human Parvovirus B19. Clin Microbiol Rev 15 (2002) 485-505
85. Enders M., Weidner A., Zoellner I., et al. Fetal morbidity and mortality after acute human parvovirus B19 infection in pregnancy: prospective evaluation of 1018 cases. Prenat Diagn 24 (2004) 513-518
86. Miller E., Fairley C.K., Cohen B.J., et al. Immediate and long term outcome of human parvovirus B19 infection in pregnancy. Br J Obstet Gynaecol 105 (1998) 174-178
87. Yaegashi N., Niinuma T., Chisaka H., et al. The incidence of, and factors leading to, parvovirus B19-related hydrops fetalis following maternal infection; report of 10 cases and meta-analysis. J Infect 37 (1998) 28-35
88. Beersma M.F.C., Claas E.C.J., Sopaheluakan T., et al. Parvovirus B19 viral loads in relation to VP1 and VP2 antibody responses in diagnostic blood samples. J Clin Virol 34 (2005) 71-75
89. Fairley C.K., Smoleniec J.S., Caul O.E., et al. Observational study of effect of intrauterine transfusions on outcome of fetal hydrops after parvovirus B19 infection. Lancet 346 (1995) 1335-1337
90. Rodis J.F., Rodner C., Hansen A.A., et al. Long-term outcome of children following maternal human parvovirus B19 infection. Obstet Gynecol 91 (1998) 125-128