Rectification of radiation-induced damage in swiss albino mice by aloe vera leaf extracts (AVE)

Iranian Journal of Radiation Research

Volumn 5, Issue 2, 2007, Pages 71-78

  Gehlot, P ^a   Goyal, P K ^a  

^a UNIVERSITY OF RAJASTHAN   (India)

Author keywords

Aloe vera; Gamma irradiation; GSH; LPO; Swiss albino mice

Indexed keywords

ALOE VERA EXTRACT; COBALT 60; GLUTATHIONE; LIPID; WATER;

ALOE VERA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; AUTOPSY; CELL COUNT; CELL SURVIVAL; COBALT TELETHERAPY; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; GAMMA RADIATION; GOBLET CELL; INTESTINE CRYPT; INTESTINE VILLUS; IONIZING RADIATION; LIPID PEROXIDATION; MITOSIS; MOUSE; NONHUMAN; PLANT LEAF; RADIATION EXPOSURE; RADIATION INJURY; RADIATION PROTECTION; RADIATION SICKNESS; TIME; TREATMENT DURATION;

EID: 39049096731     PISSN: 23223243     EISSN: 17284562     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Maisin JR (1968) Influence of a mixture of chemical protectors on the lymphopoietic and hematopoietic system of mice irradiated with a dose of 2000 R of X-rays. Experientia, 24: 230-1.
2. Daga SS, Jain VK, Goyal PK (1995) Radioprotection effect of Liv.52 (a herbal preparation) against radiation induced hematological changes in mice. Proc Nat Acad Sci India, 65(b).
3. Bisht KS, Prabhu S, Uma Devi P (2000) Modification of radiation induced damage in mouse intestine by WR-2721. Indian J Exp Biol, 38: 669-674.
4. Pande S, Kumar M, Kumar A (1998) Evaluation of radiomodifying effects of root extract of Panax ginseng. Phytothe Res, 12: 13-17.
5. Samarth RM, Panwar M, Kumar M, Kumar A (2006) Radioprotective influence of Mentha piperita (Linn) against gamma irradiation in mice: Antioxidant and radical scavenging activity. Int J Radiat Biol, 82: 331-337.
6. Monobe M, Hino M, Sumi M, Uzawa A, Hirayama R, Ando K, Kojima S (2005) Protective effects of melatonin of -ray induced intestinal damage. Int J Radiat Biol, 81: 855-860.
7. Atherton P (1998) Aloe vera: magic or medicine? Nurs stand, 12. 49-54.
8. Klein A and Penneys N (1988). Aloe vera. J Amer Acad Dermatol, 18: 714- 719.
9. Shelton RM (1991) Aloe vera: Its chemical and therapeutic properties. Int Dermatol, 30: 679-683.
10. Moron MS, Depierre JW, Mannervick B (1979) Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Bichem Biophys Acta, 582: 67-78.
11. Ohkhawa H, Ohishi N, Yogi K (1979) Assay for lipid peroxidation in animal tissue by thiobarbituric acid reaction. Analyt Biochem, 95: 351.
12. Uma Devi P, Ganasoundari A, Rao BSS, Srinivasan KK (1999) In vivo radioprotection by Ocimum sanctum flavonoids: Survival of mice. Radiat Res, 151: 74-78.
13. Jagetia GS and Baliga MS (2005) The effect of seasonal variation on the antineoplatic activity of Alstonia schlaris R. Br. In Hela Cells. J Ethanopharmacol, 96: 37-42.
14. Withers HR and Elkind M (1969) Radiosensitivity and fractionation response of crypt cells of mouse jejunum. Radiat Res, 38: 598-613.
15. Bergonie J and Tribondeau L (1906) Interpretation de quelques resultats de la radiotherapie et esal de fixation d'ine technique rationelle. Compt Rend Acad. Sci, 143., 983,
16. Uma Devi P, Saini MR, Saharan BR, Bhartiya HC (1979) Radioprotective effect of 2-MPG on the intestinal crypt of the Swiss albino mice after Co60 irradiation. Radiat Res, 80: 214-220.
17. Goel HC, Salin CA, Prakash H (2003) Protection of jejunal crypts by RH-3(a preparation of Hippophae rhamnoides) against lethal whole body gamma irradiation. Phytother Res, 17: 222-226.
18. Baker DG and Hopper AF (1968) Crypt cell population changes in rat intestine during injury and repair after first neutron irradiation. Radiat Res, 34: 555.
19. Vidrich A, Buzan JM, Barnes S, Reuter B, Skaar K, lio C, Caminelli F, Pizarro T, Chon SM (2005) Altered epithelial cell lineage allocation and global expansion of the crypt epithelial stem cell population are associated with ileitis in SAMP1 YitFc mice. American J Pathol, 166: 1055-1067.
20. Nandchahal K (1990) Crypt cell population in the murine jejunum during injury and repair after whole-body gamma-irradiation. Radiobiology Radiother, 31: 337.
21. Elkind MM and Whetmore GF (1967) The radiobiology of cultured mainmalian cells. Gondon and Breach Science Publishers. Inc. New York.
22. Gillette EL, Withers HR, Jannock IF (1970) The age sensitivity of epithelial cells of mouse small intestine. Radiobiol, 96: 639.
23. Lesher S (1967) Compensatory reactions in intestinal crypt cells after 300 Roentgens of Cobalt-60 gamma irradiation. Radiat Res, 32: 501.
24. Davik F (1968) Quantitative cellular aspects of the epithelium in the small intestine of mouse following total body irradiation: Cell death, mitosis and chromosome aberrations. In:" Effect of radiation on cellular proliferation and differentiation". IAEA, Vienna, 531.
25. Gehlot P and Goyal PK (2006) Evaluation of radioprotective efficacy of Aloe vera leafextract in mouse intestinal mucosa after low level exposure to gamma radiation. J Enviorn & Sociobiol, 3: 93-100.
26. Prasanna PGS and Uma Devi P (1971) Modification of WR-2721 radiation protection from gastrointestinal injury and death in mice by 2-mercaptopropionylglycine. Radiat Res, 133: 111.
27. Samarth RM, Saini MR, Maharwal J, Dhaka A, Kumar A (2002) Mentha piperita (Linn.) Leaf extract provides protection against radiation induced alterationsin intestinal mucosa of Swiss albino mice. Indian J Exp Biol, 40: 1245-1249.
28. Kosower NS and Kosower EM (1978) The glutathione status of the cell. Int Rev Cytol, 54: 109-160.
29. Mitchell JR, Hinson JA, Nelson SD (1976) Glutathione and drug induced tissuelesions. In: Glutathione: metabolism and Function (Arias IM, and Jakoby WB eds.), Raven Press, New York; pp: 357-366.
30. Konnings AWT and drijver EB (1979) Radiation effect on membranes. I. Vitamin E deficiency and lipid peroxidation. Radiat Res, 80: 494.
31. Konnigs AWT and Osterloo SK (1979) Radiation effect on membranes. II. A comparison of the effect of X-irradiation and ozone exposure with respect to the relation of antioxidant concentration and the capacity for lipid peroxidation. Radiat Res, 81, 200.
32. Sabeh I, Wright T, Nortan SJ (1993) Purification and characterization of a glutathione peroxidase from the Aloe vera plant. Enzeme protein, 47: 92-98.
33. Nikki, E (1991) Vitamin C as an antioxidant. World reviews of nutrition and Dielectrics, 64: 1-30.
34. Burton GM and Ingold KV (1989) Vitamin E as in vitro and in in vivo antioxidant. Annals of the New York Academy of Sciences. 570: 7-22.