Decreased non-insulin-dependent glucose clearance contributes to the rise in fasting plasma glucose in the nondiabetic range

Diabetes Care

Volumn 31, Issue 2, 2008, Pages 311-315

  Jani, Rucha ^a   Molina, Marjorie ^a   Matsuda, Masafumi ^a   Balas, Bogdan ^a   Chavez, Alberto ^a   DeFronzo, Ralph A ^a   Abdul Ghani, Muhammad ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; ORAL GLUCOSE TOLERANCE TEST;

ADULT; BLOOD GLUCOSE; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FASTING; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; LIVER; MALE; METABOLIC CLEARANCE RATE; REFERENCE VALUES;

EID: 38949187199     PISSN: 01495992     EISSN: 01495992     Source Type: Journal    
DOI: 10.2337/dc07-1593     Document Type: Article

References (21)

1. DeFronzo RA: Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 8:787- 835, 2004
2. Abdul-Ghani MA, Jenkinson CP, Richardson DK, Tripathy D, DeFronzo RA: Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study. Diabetes 55:1430-1435, 2006
3. Abdul-Ghani MA, Tripathy D, DeFronzo RA: Contributions of β-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care 29:1130-1139, 2006
4. Katz LD, Glickman MG, Rapoport S, Ferrannini E, DeFronzo RA: Splanchnic and peripheral disposal of oral glucose in man. Diabetes 32:675-679, 1983
5. Mari A, Wahren J, DeFronzo RA, Ferrannini E: Glucose absorption and production following oral glucose: comparison of compartmental and arteriovenous-difference methods. Metabolism 43:1419-1425, 1994
6. DeFronzo RA: Pathogenesis of type 2 diabetes mellitus: metabolic and molecular implications for identifying diabetes genes. Diabetes Rev 5:117-269, 1997
7. DeFronzo RA, Ferrannini E: Regulation of hepatic glucose metabolism in humans. Diabete Metab Rev 3:415-459, 1987
8. DeFronzo RA, Ferrannini E, Simonson DC: Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism 38:387-395, 1989
9. Sindelar DK, Chu CA, Venson P, Donahue EP, Neal DW, Cherrington AD: Basal hepatic glucose production is regulated by the portal vein insulin concentration. Diabetes 47:523-529, 1998
10. Cherrington AD: Banting Lecture 1997: Control of glucose uptake and release by the liver in vivo. Diabetes 48:1198-214, 1999
11. Jeng CY, Sheu WH, Fuh MM, Chen YD, Reaven GM: Relationship between hepatic glucose production and fasting plasma glucose concentration in patients with NIDDM. Diabetes 43:1440-1444, 1994
12. Steele RW, Wall JS, DeBodo RC, Altszuler N: Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol 187:15-24, 1956
13. Matsuda M, DeFronzo RA: Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462-1470, 1999
14. Abdul-Ghani MA, Jenkinson C, Richardson DK, DeFronzo RA: Impaired early but not late phase insulin secretion during OGTT in subjects with isolated impaired fasting glucose. Eur J Clin Invest. In press
15. DeFronzo RA: Lilly Lecture 1987: The triumvirate: β-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes 37:667-687, 1988
16. Del Prato S, Matsuda M, Simonson DC, Groop LC, Sheehan P, Leonetti P, Bonadonna RC, DeFronzo RA: Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance. Diabetologia 40:687-697, 1997
17. Koistinen HA, Zierath JR: Regulation of glucose transport in human skeletal muscle. Ann Med 34:410-418, 2000
18. Petersen KF, Shulman GI: Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. Am J Cardiol 90:11G-18G, 2002
19. Ciaraldi TP, Mudaliar S, Barzin A, Macievic JA, Edelman SV, Park KS, Henry RR: Skeletal muscle GLUT1 transporter protein expression and basal leg glucose uptake are reduced in type 2 diabetes. J Clin Endocrinol Metab 90:352-358, 2005
20. Henry RR, Abrams L, Nikoulina S, Ciaraldi TP: Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects: comparison using human skeletal muscle cell cultures. Diabetes 44:936-946, 1995
21. DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP: The effect of insulin on the disposal of intravenous glucose: results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30:1000-1007, 1981